Herpesvirus-associated central and peripheral nervous system involvement: two clinical cases

Попова, Т. Е.; Шнайдер, Н. А.; Петрова, М. М.; Николаева, Т. Я.; Кантимирова, Е. А.; Исаева, Н. В.; Шнайдер, В. А.; Панина, Ю. С.; Дюжакова, А. В.; Дюжаков, С. К.

doi:10.14412/2074-2711-2015-2-28-34

Cited by 1 publication

(1 citation statement)

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“…According to this fact, some authors consider the development of SARS-CoV-2-associated para-infectious LE caused by secondary hyperinflammatory syndrome with a massive release of proinflammatory cytokines and chemokines in the limbic system of the brain [21,57,58]. Taken together, these facts explain the scientific and clinical interest in studying the role of proinflammatory cytokines, including interleukin-1-beta (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in the development of para-infectious LE associated with SARS-CoV-2, as overexpression of these cytokines has been described in previous studies of drug resistant para-infectious temporal lobe epilepsy [59][60][61][62][63] and also in cognitive disorders including shot-term and long-term memory [64] and Alzheimer's type dementia [65].…”

Section: Metabolitementioning

confidence: 79%

Limbic Encephalitis Associated with COVID-19

et al. 2021

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Limbic encephalitis (LE) is an inflammatory disease of the brain, in which lesion is anatomically limited in structures of the limbic system. In some cases, LE can start with symptoms of limbic dysfunction with further involvement of other regions of the brain. Classic LE syndrome includes such symptoms as the development of personality disorders, depression, sleep disorders, epileptic seizures, hallucinations and cognitive disorders (short-term and long-term memory impairment). The information of clinical examination, electroencephalogram (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid studies (CSF) suggest the diagnosis of LE in most patients with Coronavirus Disease 2019 (COVID-19).

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