Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats

Olumegbon, Lateefat T.; Lawal, Akeem O.; Oluyede, Dare M.; Adebimpe, Monsurat O.; Elekofehinti, Olusola Olalekan; Umar, Haruna Isiyaku

doi:10.1007/s11356-022-19494-3

Cited by 16 publications

(7 citation statements)

References 51 publications

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“…These mechanisms are achieved by regulating the TLR4 signaling pathway, oxidative stress, and lipid metabolism (Xue et al, 2021). Baicalin (Wu et al, 2018b), wogonin (Wu et al, 2019), and hesperitin (Olumegbon et al, 2022) inhibit plaque formation via anti-inflammatory and anti-oxidative stress mechanisms, and play roles in protecting blood vessels.…”

Section: Flavonoidsmentioning

confidence: 99%

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways

Meng

Li²,

Li³

et al. 2022

Front. Pharmacol.

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Atherosclerosis (AS) is a prevalent arteriosclerotic vascular disease that forms a pathological basis for coronary heart disease, stroke, and other diseases. Inflammatory and oxidative stress responses occur throughout the development of AS. Treatment for AS over the past few decades has focused on administering high-intensity statins to reduce blood lipid levels, but these inevitably damage liver and kidney function over the long term. Natural medicines are widely used to prevent and treat AS in China because of their wide range of beneficial effects, low toxicity, and minimal side effects. We searched for relevant literature over the past 5 years in databases such as PubMed using the keywords, “atherosclerosis,” “traditional Chinese medicine,” “natural medicines,” “inflammation,” and “oxidative stress.” We found that the PI3K/AKT, TLR4, JAK/STAT, Nrf2, MAPK, and NF-κB are the most relevant inflammatory and oxidative stress pathways in AS. This review summarizes studies of the natural alkaloid, flavonoid, polyphenol, saponin, and quinone pathways through which natural medicines used to treat AS. This study aimed to update and summarize progress in understanding how natural medicines treat AS via inflammatory and oxidative stress-related signaling pathways. We also planned to create an information base for the development of novel drugs for future AS treatment.

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Section: Flavonoidsmentioning

confidence: 99%

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways

Meng

Li²,

Li³

et al. 2022

Front. Pharmacol.

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“…ROS, derived from the metabolism of oxygen, plays a pivotal role as an important physiological regulator of living organisms (Finkel, 2011); excessive ROS augments intracellular oxidative stress to damage cells (Dan Dunn, Alvarez, Zhang, & Soldati, 2015). Previous researches have shown that HSP has the ability to mitigate of oxidative stress in the cardiovascular system (Olumegbon et al, 2022; Velusamy et al, 2020). Our findings show a high ROS generation in CoCl 2 ‐treated cells consistent with the increase of free radicals in myocardial cell injury, while they were all reversed in HSP‐treated cells (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

“…However, because the cardiac functions are regulated by a variety of neurotransmitters, hormones, and cytokines, there may be many factors affecting the process, so we further explore the protective mechanism of HSP with H9c2 cardiomyocytes and the isolated rat Soldati, 2015). Previous researches have shown that HSP has the ability to mitigate of oxidative stress in the cardiovascular system (Olumegbon et al, 2022;Velusamy et al, 2020). Our findings show a high ROS generation in CoCl 2 -treated cells consistent with the increase of free radicals in myocardial cell injury, while they were all reversed in HSP-treated cells (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis

Chen

et al. 2022

Phytotherapy Research

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Ischemia/hypoxia (I/H)-induced myocardial injury has a large burden worldwide. Hesperetin (HSP) has a cardioprotective effect, but the molecular mechanism underlying this is not clearly established. Here, we focused on the protective mechanisms of HSP against I/H-induced myocardium injury. H9c2 cardiomyocytes were challenged with CoCl 2 for 22 h to imitate hypoxia after treatment groups received HSP for 4 h. The viability of H9c2 cardiomyocytes was evaluated, and cardiac function indices, reactive oxygen species, apoptosis, mitochondrial membrane potential (MMP), and intracellular Ca 2+ concentration ([Ca 2+ ] i ) were measured. L-type Ca 2+ current (I Ca-L ), myocardial contraction, and Ca 2+ transients in isolated ventricular myocytes were also recorded. We found that HSP significantly increased the cell viability, and MMP while significantly decreasing cardiac impairment, oxidative stress, apoptosis, and [Ca 2+ ] i caused by CoCl 2 . Furthermore, HSP markedly attenuated I Ca-L , myocardial contraction, and Ca 2+ transients in a concentration-dependent manner.Our findings suggest a protective mechanism of HSP on I/H-induced myocardium injury by restoring oxidative balance, inhibiting apoptosis, improving mitochondrial function, and reducing Ca 2+ influx via L-type Ca 2+ channels (LTCCs). These data provide a new direction for HSP applied research as a LTCC inhibitor against I/H-induced myocardium injury.

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“…The amplicons were separated on a 1.0% agarose gel. The GAPDH gene served as a normalization control for each gene's relative expression level, and band intensity was quantified using "ImageJ" software [41]. The primer sequences are provided below.…”

Section: Pcr Amplification and Agarose Gel Electrophoresismentioning

confidence: 99%

Artocarpus Communis Seed Regulates P53, IRS, HsD17β2, FTO, and CYP11a Genes in Polycystic Ovarian Syndrome Rats

Ogunlakin,

Ojo,

Onu-Boms

et al. 2024

OBM Genet

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Polycystic ovarian syndrome (PCOS) is a prevalent endocrine illness that affects 5-10% of reproductive women globally. It is a multifaceted hormonal disorder characterized by the involvement of numerous molecular mechanisms that contribute to its development. This study investigates the effect of Artocarpus communis seed on the hormonal imbalance and P53, IRS, HsD17β2, FTO, and CYP11a genes expression in the ovaries of letrozole-induced polycystic ovarian syndrome rats. To induce PCOS in 30 female Wistar rats, letrozole was administered at a dosage of 1 mg/kg. For 12 days, Artocarpus communis seed aqueous extract (100 and 250 mg/kg body weight) and Clomiphene citrate (1 mg/kg body weight), a standard medication, were given. ELISA assessed luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol levels. The levels of P53, IRS, HsD17β2, FTO, and CYP11a gene expression in the ovaries were assessed. The aqueous extract reduced LH and increased FSH levels in Letrozole-induced PCOS rats. Additionally, seed aqueous extract (250 mg/kg bw) regulated the expression of P53, type 2 17-HSD (17-HSD), fat mass and obesity-associated (FTO), 11a-hydroxylase/17,20-desmolase (CYP11a), and insulin receptor substrate (IRS) genes in the ovaries of PCOS rats. Therefore, Artocarpus communis seed might have multifaceted effects on molecular pathways associated with PCOS, potentially normalizing androgen metabolism, hormonal imbalance, and ovarian function.

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Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats

Cited by 16 publications

References 51 publications

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis

<i>Artocarpus Communis</i> Seed Regulates P53, IRS, HsD17β2, FTO, and CYP11a Genes in Polycystic Ovarian Syndrome Rats

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Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats

Cited by 16 publications

References 51 publications

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca2+ homeostasis

<i>Artocarpus Communis</i> Seed Regulates P53, IRS, HsD17β2, FTO, and CYP11a Genes in Polycystic Ovarian Syndrome Rats

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Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis