Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage

Sahu, Bidya Dhar; Kuncha, Madhusudana; Sindhura, G. Jeevana; Sistla, Ramakrishna

doi:10.1016/j.phymed.2012.12.001

Cited by 207 publications

(138 citation statements)

References 28 publications

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“…Sahu et al (2013) indicated that oral hesperidin administration significantly increased serum levels of GSH, GST, GR and GSH-Px as well as decreased the expression of lipid peroxidation in rats. It was reported that serum SOD levels were relatively high after hesperidin supplementation, resulting in a reduced superoxide anion concentration in laying hens (Lien et al, 2008).…”

Section: Discussionmentioning

confidence: 93%

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender

Yenice

Dokumacıoğlu

et al. 2016

Rev. Bras. Cienc. Avic.

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Ninety-six 28-week-old Lohmann White laying hens were utilized to test the antioxidant effects of flavonoids (hesperidin, naringin, and quercetin at 0.5 g/kg diet) during an 8-wk experimental period. At the end of the experiment blood samples were collected to determine total protein, cholesterol, and malondialdehyde (MDA) serum levels as well as activities of glutathione reductase (GR), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and superoxide dismutase (SOD) and level of glutathione (GSH) in erythrocyte lysates. Data were analyzed using one-way ANOVA. Naringin supplementation did not alter serum cholesterol concentration, whereas hesperidin and quercetin supplementations decreased serum cholesterol concentration. Naringin and quercetin supplementations did not affect serum protein concentration. All flavonoids decreased MDA concentration as well as increased GSH-Px, GR, GST, and SOD activities and GSH level, being quercetion superior to hesperidin and naringin. In conclusion, flavonoids, especially quercetin, exert antioxidant activity, which may help improve wellbeing when laying hens are exposed to stressors.

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Section: Discussionmentioning

confidence: 93%

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender

Yenice

Dokumacıoğlu

et al. 2016

Rev. Bras. Cienc. Avic.

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“…42 Sahu et al 42 reported that hesperidin ameliorated neutrophil infiltration as evidenced by inhibition of MPO levels in kidney tissues. Also Kamel et al 5 suggested that hesperidin administration decreased inflammatory cell infiltration in kidney tissues of cisplatin-induced rats.…”

Section: 6mentioning

confidence: 99%

Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

Kaltalıoğlu

Cevher

2016

Renal Failure

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Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into seven groups: control, morin, hesperidin, cisplatin, cisplatin þ morin, cisplatin þ hesperidin, and cisplatin þ morin þ hesperidin. Morin and/or hesperidin were given for 10 consecutive days by oral gavage and on the 4th day a single dose of cisplatin (7 mg/kg) was injected intraperitoneally. After administrations, on the 11th day of the experiment the animals were killed, and malondialdehyde (MDA), nitric oxide (NOx), glutathione (GSH) levels and myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD) activity were measured. Cisplatin-treated rats showed increased levels of MDA, and decreased levels of NOx also activity of CAT. Morin and/or hesperidin pretreatment prevent oxidative stress in kidney tissue, while they increase the NOx level, CAT activity, and decrease MPO activity. In conclusion, morin þ hesperidin pretreatment may have a significant potential for protection of cisplatin-induced nephrotoxicity.ARTICLE HISTORY

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“…substantial evidence indicates that the production of ros by cddp in the kidney is crucial to the progression of nephrotoxicity 31 . The ros are seen as early signs partially responsible for the activation of various signaling pathways that culminate in kidney failure, renal injury, and cell death in the event of cddp-induced nephrotoxicity 2 .…”

Section: Discussionmentioning

confidence: 99%

The aqueous extract of cinnamon bark ameliorated cisplatin-induced cytotoxicity in vero cells without compromising the anticancer efficiency of cisplatin

Elkady¹,

Ramadan²

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage

Cited by 207 publications

References 28 publications

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

The aqueous extract of cinnamon bark ameliorated cisplatin-induced cytotoxicity in vero cells without compromising the anticancer efficiency of cisplatin

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