Hetero-coagulation of polymeric core-corona microspheres

Serizawa, Takeshi; Taniguchi, Kouta; Akashi, Mitsuru

doi:10.1016/s0927-7757(00)00421-0

Cited by 14 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The size of the nanoparticles (100 nm to 3 mm) could be controlled by changing the polymerization conditions [43,44] with functional polymeric branches on their surfaces could be obtained. For instance, we have already developed nanoparticles bearing pH sensitive anionic poly(methacrylic acid) (PMAA) [37], cationic poly(vinylamine) (PVAm) [52], nonionic poly(ethylene glycol) (PEG) [44], thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) [39] and poly(Nvinylisobutyramide) (PNVIBA) [42]. Regulating the monomers used and the reaction conditions can easily control their surface properties, such as the density or molecular weight of their hydrophilic polymers, the charge or its distribution, and the stimuli responses.…”

Section: Preparation Of Core-corona Type Polymeric Nanoparticlesmentioning

confidence: 99%

Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments: Potential applications

Akagi

Baba

Akashi

2007

Polymer

Self Cite

105

View full text Add to dashboard Cite

This review describes the preparation of core-corona type polymeric nanoparticles and their applications in various technological and biomedical fields. Over the past two decades, we have studied the synthesis and clinical applications of core-corona polymeric nanoparticles composed of hydrophobic polystyrene and hydrophilic macromonomers. These nanoparticles were utilized as catalyst carriers, carriers for oral peptide delivery, virus capture agents, and vaccine carriers, and so on. Moreover, based on this research, we attempted to develop novel biodegradable nanoparticles composed of hydrophobic poly(g-glutamic acid) (g-PGA) derivatives (g-hPGA). Various model proteins were efficiently entrapped on/into the nanoparticles under different conditions: encapsulation, covalent immobilization, and physical adsorption. The encapsulation method showed the most promising results for protein loading. It is expected that biodegradable g-hPGA nanoparticles can encapsulate and immobilize various biomacromolecules. Nanoparticles consisting of hydrophobic and hydrophilic segments have great potential as multifunctional carriers for pharmaceutical and biomedical applications, such as drug, protein, peptide or DNA delivery systems.

show abstract

Section: Preparation Of Core-corona Type Polymeric Nanoparticlesmentioning

confidence: 99%

Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments: Potential applications

Akagi

Baba

Akashi

2007

Polymer

Self Cite

105

View full text Add to dashboard Cite

show abstract

“…Core-corona nanospheres were prepared by free radical copolymerization of St and p-chloromethylstyrene-terminated macromomers of MAA 5 of polymerization time. The total amount of monomers was fixed to 1 g. After purification by three times centrifugation using water, PSt nanospheres with both PMAA and PNIPAAm corona dispersed in water (respective solution pH of 2 and 6) were obtained.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3] During polymerization, amphiphilic graft polymers assemble in solution to form corecorona nanospheres, which have hydrophobic cores and hydrophilic corona layers on their surfaces, resulting in excellent aqueous phase dispersion. Surface functionalities (neutral, [1][2][3] cationic, 4,5 anionic, 5,6 thermoresponsive units 7,8 ) can be readily modified by changing the macromonomer, and nanosphere size (e.g., 50 nm to 1 mm) can also be controlled by changing polymerization conditions. [9][10][11][12][13][14][15][16][17] Furthermore, size distribution is narrow in all cases.…”

mentioning

confidence: 99%

Cross-sectional Morphologies of Polystyrene Nanospheres with Hydrophilic Corona Surfaces

Serizawa

Yanagisono

Ueno

et al. 2005

Polym J

Self Cite

View full text Add to dashboard Cite

KEY WORDSCore-Corona Nanosphere / Cross-Section / Morphology / Transmission Electron Microscope / Macromonomer / [DOI 10.1295/polymj.37.39] Polymeric nanospheres have potential applications in technological and biotechnological fields. It is important to control the nanosphere structures (e.g., sizes, size distributions, surface functionalities, and chemical compositions), followed by the development of new polymerization system. We have already developed a synthetic method for polymeric nanospheres, based on free radical copolymerization of hydrophobic monomers (styrene and methyl methacrylate) and hydrophilic macromonomers in polar organic solvents.

show abstract

“…Surface charge of nanoparticles could be controlled by using cationic poly(vinylamine) and anionic poly(methacrylic acid) having a polymerizable end group as macromonomers [7,14]. To prepare the ionic nanoparticles, macromonomer chains on the nanoparticle surface were hydrolyzed after dispersion copolymerization.…”

Section: Preparation Of Core-corona Nanopar-ticlesmentioning

confidence: 99%

“…Using functional groups introduced on the coronas, proteins, peptides, saccharides, and metal nanoparticles could be easily conjugated on nanoparticle surfaces. Consequently, these core-corona nanoparticles have been utilized to various technological and biomedical applications, such as catalyst carriers [6], integrated materials [7], oral peptide drug carriers [8], diagnostic drugs, and virus captures.…”

Section: Introductionmentioning

confidence: 99%

Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine

Wang¹,

Akagi²,

Akashi³

et al. 2007

MROC

Self Cite

View full text Add to dashboard Cite

We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of inducing humoral and cellular immune responses to HIV-1, they could be developed as a mucosal vaccine against HIV-1 infection.

show abstract

Hetero-coagulation of polymeric core-corona microspheres

Cited by 14 publications

References 29 publications

Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments: Potential applications

Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments: Potential applications

Cross-sectional Morphologies of Polystyrene Nanospheres with Hydrophilic Corona Surfaces

Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine

Contact Info

Product

Resources

About