Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT

King, Gregory G.; Carroll, Jessica; Müller, N L; Whittall, Kenneth P.; Gao, Mengge; Nakano, Yasutaka; Paré, Peter D.

doi:10.1183/09031936.04.00047503

Cited by 101 publications

(107 citation statements)

References 28 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…GOLDIN et al [75] reported greater decreases in FEV1 and in airway lumen area in small airways after inhalation of methacholine in asthmatic as opposed to normal subjects. KING et al [27] have recently shown that airway narrowing is heterogeneous in the large airways of asthmatics, and that this heterogeneity is larger than in control subjects.…”

Section: Airway Imaging In Asthma Airway Dimensionsmentioning

confidence: 99%

“…KING et al [27] measured heterogeneity in airway narrowing by comparing the variation within a scan to that between scans. However, this study did not address the issue of heterogeneity in baseline airway dimensions, which is important to estimate before the quantitative assessment of airway dimensions is established as an outcome measure in clinical studies.…”

Section: Quantitative Assessment Of Smaller Airwaysmentioning

confidence: 99%

See 1 more Smart Citation

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

Eur Respir J

157

View full text Add to dashboard Cite

Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.

show abstract

Section: Airway Imaging In Asthma Airway Dimensionsmentioning

confidence: 99%

Section: Quantitative Assessment Of Smaller Airwaysmentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

Eur Respir J

157

View full text Add to dashboard Cite

show abstract

“…According to current literature, radiographic measurements of bronchi that are smaller than segmental ones are problematic [23]. Size determination (e.g.…”

Section: Discussionmentioning

confidence: 99%

Adjusted subpixel method enables optimisation of bronchial measurements in high-resolution CT

Mincewicz¹,

Aloszko²,

Rumiński³

et al. 2012

The British Journal of Radiology

View full text Add to dashboard Cite

Objectives: The purpose of this paper is to present a new technique of high-resolution computed tomography (HRCT) bronchial measurement, which was worked out in our centre and is based on a mathematically adjusted subpixel method (ASM). Methods: This study used a bronchial tree model comprising two polyvinyl chloride/ rubber pipes with various densities placed in a larger plastic object. External and internal diameters of both pipes corresponded to the sizes of structures that are usually evaluated in HRCT scans (i.e. the bronchus with accompanying blood vessel). The model was subjected to repeated HRCT measurements of the external and internal diameters of model pipes using a subpixel technique and ASM. Results: Significant differences were observed between mean values of external and internal diameters of model pipes determined by means of subpixel method or ASM, with the latter being the ones that resembled real diameters of the model pipes more closely. Mean external diameters of the larger and smaller model pipes determined by ASM differed from the real diameters by 0.23% and 0.57%, respectively. The internal diameter of the larger pipe was on average 25.96% larger, whereas the internal diameter of the smaller pipe was 48.05% smaller than the real diameter. Conclusion:The technique of non-linear prediction of HRCT bronchial measurements described in this paper raises attractive prospects in its clinical application owing to potential improvements in the objectivity and reproducibility of bronchial wall measurements. High-resolution CT (HRCT) has recently gained increasing attention as an evaluation method of bronchial remodelling in asthma patients [1]. The efficiency of HRCT has been proven by numerous studies [2][3][4][5]. Optimisation of the radiation beam parameters enables identification of structures down to 100-200 mm in size and allows for evaluation of even the smallest bronchi (1.5-2 mm in diameter) [6]. Because of the aforementioned characteristics, HRCT is useful in the diagnosis and evaluation of many pathologies, including bronchial wall thickening, bronchiectasis, mucus plugging and emphysema or atelectasis [7][8][9][10][11].Owing to its many advantages, HRCT is likely to become the standard tool for disease evaluation in patients with difficult/refractory asthma [12][13][14][15]. However, a number of constraints are associated with the application of this otherwise valuable method. The first constraint is the lack of clearly defined clinical criteria for asthma evaluation in HRCT scans [16]. Among the proposed criteria, disease-related changes in bronchial wall thickness and bronchial lumen diameter seem to be the most reasonable. However, repeating and comparing measurements obtained at different time points is often frustrated by the low reproducibility of HRCT-based measurements. This problem results mostly from the wide use of eye-driven, non-standardised techniques of measurements.A number of attempts towards optimising HRCT measurements have been undertaken, mostly based on model syste...

show abstract

“…Following MCh challenge, Brown et al [30] reported airway reductions with standard error values sufficient to suggest that for airways >7 mm at baseline, dilation instead of constriction after bronchoprovocation occurred in slightly less than half of the airways in healthy subjects, and slightly less than 16% of the airways in asthmatic subjects. Likewise, Bland-Altman plots put forth by King et al [29] show 18.5% of measured healthy airways and 20.8% of measured asthmatic airways dilated following MCh challenge. Both studies include data from airways smaller than what we can measure using HP 3 He MRI.…”

Section: Pathophysiological Implicationsmentioning

confidence: 99%

“…Instead of grouping imaged airways by size and confined to particular locations [29][30][31][32], this study tracked individual central airway calibers. HP 3 He MRI could be established as a viable alternative for quantitatively assessing bronchial response if it could be demonstrated that it measures airway diameter changes comparable to those derived from MDCT data.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Hyperpolarized 3He Magnetic Resonance Imaging Utility in Examining Human Airway Diameter Behavior in Asthma Through Comparison with High-Resolution Computed Tomography

Tzeng¹,

Hoffman²,

Cook-Granroth³

et al. 2008

Academic Radiology

View full text Add to dashboard Cite

Rationale and Objectives-Application of a previously developed model-based algorithm on hyperpolarized (HP) 3 He MR dynamic projection images of phantoms was extended to investigate the utility of HP 3 He MRI in quantifying airway caliber change associated with asthma.Materials and Methods-Airways of seven volunteers were imaged and measured using HP 3 He MRI and multidetector-row computed tomography (MDCT) before and after a methacholine (MCh) challenge. MDCT data was obtained at functional residual capacity (FRC) and one liter above FRC (FRC+1L).Results-Comparison of the resultant data showed that HP 3 He MRI did not match MDCT in measuring the ratios of airway calibers before and after the MCh challenge in 37%-43% of the airways from the first six generations at the two lung volumes tested. However, MDCT did lead to the observation that 49%-69% of these airways displayed bronchodilation following MCh challenge. Conclusion-The current implementation of HP 3 He MRI did not match the MCh-induced postchallenge to pre-challenge airway caliber ratios as measured with MDCT. Elevated parenchymal tethering due to bronchoconstriction-induced hyperinflation was proposed as a possible explanation for this airway dilation.

show abstract

Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT

Cited by 101 publications

References 28 publications

Computed tomographic imaging of the airways: relationship to structure and function

Computed tomographic imaging of the airways: relationship to structure and function

Adjusted subpixel method enables optimisation of bronchial measurements in high-resolution CT

Investigation of Hyperpolarized 3He Magnetic Resonance Imaging Utility in Examining Human Airway Diameter Behavior in Asthma Through Comparison with High-Resolution Computed Tomography

Contact Info

Product

Resources

About