Heterogeneity of post-COVID impairment: interim analysis of a prospective study from Czechia

Skála, Martin; Svoboda, Michal; Kopecký, Michal; Kočová, Eva; Hyrsl, Martin; Homolac, Michal; Chrobok, Viktor; Boštík, Pavel; Fajfr, Miroslav; Prášil, Petr; Plíšek, Stanislav; Sleha, Radek; Koblížek, Vladimír

doi:10.1186/s12985-021-01546-8

Cited by 22 publications

(18 citation statements)

References 14 publications

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“… Radar chart illustrating the prevalence of the specific long COVID symptoms in the cohort studies with study number indicated on the circle circumference [ 15 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , ...…”

Section: Resultsmentioning

confidence: 99%

Most Common Long COVID Physical Symptoms in Working Age Adults Who Experienced Mild COVID-19 Infection: A Scoping Review

et al. 2022

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Background: One-third of patients who recover from COVID-19 present with long COVID. Their symptoms are broad, affecting their physical functioning and, ultimately, their quality of life. Many of those individuals who develop long COVID, possibly from a mild COVID-19 infection, are in the 18–65 age group. This prolongation of malaise directly influences national workforce economies. Objectives: To summarise the commonly reported physical symptoms of long COVID in order to inform potential adjustments in healthcare for the employable population. Methods: The Embase, CINAHL, Medline, SCOPUS, and WHO COVID-19 databases were searched. The study selection process was based on the PRISMA guidelines. The extracted data were synthesised and presented narratively. Results: 7403 studies were accessed, comprising 60 cohort studies and 10 case series/studies, representing 289,213 patients who met our criteria. The most frequently reported physical symptoms were fatigue (92%), shortness of breath (SOB) (81.8%), muscle pain (43.6%), and joint pain (34.5%). Conclusions: The range of reported physical symptoms was broad and varied; the main ones being fatigue, breathlessness/SOB, and pain. Similarities observed between long COVID and other post-acute infection syndromes may help formulate protocols to manage and promote recovery for long COVID patients. Inconsistencies were evident, particularly with a lack of adherence to the standardised definitions of long COVID.

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Section: Resultsmentioning

confidence: 99%

Most Common Long COVID Physical Symptoms in Working Age Adults Who Experienced Mild COVID-19 Infection: A Scoping Review

et al. 2022

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“…Published June 10, 2020 , Sabes-Figuera et al, 2010 , Winston, 2020 , Xu et al, 2017 , Stroup et al, 2000 , Page et al, 2021 , Better systematic review management. Published June 11, 2020 , Stang, 2010 , Shuwa et al, 2021 , Sonnweber et al, 2021 , Taboada et al, 2021 , Todt et al, 2021 , Wong et al, 2020 , Zhou et al, 2021 , Ghosn et al, 2021 , Say et al, 2021 , Pilotto et al, 2021 , Liyanage-Don et al, 2021 , Miyazato et al, 20202020 , González et al, 2021 , Fernández-de-las-Peñas et al, 2021 , Fernández-de-Las-Peñas et al, 2021 , Arnold et al, 2021 , Fortini et al, 2021 , García-Abellán et al, 2021 , Ong et al, 20212021 , PHOSP-COVID Collaborative Group et al, 2021 , Skala et al, 2021 , Sykes et al, 2021 , Santis et al, 2020 , van den Borst et al, 2020 , Venturelli et al, 2021 , IL6 - Clinical: Interleukin 6, Plasma. Accessed June 26, 2021 , Elkan et al, 2021 , Frontera et al, 2021 , Garrigues et al, 2020 , Havervall et al, 2021 , Rogers et al, 2020 , Hoffman and Vilensky, 2017 , Komaroff and Lipkin, 2021 , Higgins et al, 2021 , Douaud et al, 2021 , Lee et al, 2021 , Guedj et al, 2021 , Libby and Lüscher, 2020 , Oronsky et al, 2021 , Yong, 2021 , Sartori et al, 2012 , Rosenblat et al, 2014 , Sonneville et al, 2009 , Gałecki et al, 2018 , Heckenberg et al, 2018 , Xiong et al, 2020 , Taquet et al, 2021 , McIntyre et al, 2019 , …”

Section: Uncited Referencesmentioning

confidence: 99%

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Ceban¹,

Ling²,

Lui³

et al. 2022

Brain, Behavior, and Immunity

1,026

658

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“…This might be due to higher sensitivity to minor reduction in respiratory function. Skala et al 25 found in their interim analysis of post-COVID-19 patients that the reporting of symptoms was more frequent in patients with higher levels of anxiety, especially in females. In their study, the pulmonary involvement was found mostly in hospitalized subjects where 77% of patients had significant pulmonary changes.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and pulmonary function tests in post-acute COVID-19 patients

Genzor¹,

Jakubec²,

Sova³

et al. 2023

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. The study analysed post-acute COVID-19 symptoms and the pulmonary function test (PFT) results in patients surviving the native strain of the virus. Methods. The study was prospective; the inclusion criteria were positive PCR test for SARS-CoV-2 and age 18-100. Exclusion criteria were active respiratory infection, known or suspicious pre-existing pulmonary disease, cardiac failure, recent or acute pulmonary embolism, anaemia, and neuromuscular diseases. The recruitment period was 1 st March 2020 -25 th December 2020. The initial examination was performed 4-12 weeks after the disease onset. All subjects underwent physical examination, anamnesis, chest x-ray and PFT.Results. The study involved 785 subjects (345 male) mean age 53.8 (SD 14.6). The disease severity groups were: mild (G1), moderate (G2) and severe/critical (G3). Anosmia was present in the acute disease phase in 45.2% of G1 patients, but only in 4.5% of G3 patients. Dyspnoea occurred frequently in more severe groups (40%, 51.8% and 63.7% for G1, G2 and G3 respectively), while cough and fatigue showed no relationship to disease severity. Females were more likely to experience persistent symptoms. PFT results were significantly decreased in more severe groups compared to the mild COVID-19 patients, diffusing capacity was 86.3%, 79% and 68% of predicted values in G1, G2 and G3 respectively. Conclusion. Anosmia during the acute phase was associated with mild disease, persisting dyspnoea was more frequent after more severe COVID-19. Females tended to have persisting symptoms in post-acute phase more frequently. PFT results showed decrease with disease severity.

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Heterogeneity of post-COVID impairment: interim analysis of a prospective study from Czechia

Cited by 22 publications

References 14 publications

Most Common Long COVID Physical Symptoms in Working Age Adults Who Experienced Mild COVID-19 Infection: A Scoping Review

Most Common Long COVID Physical Symptoms in Working Age Adults Who Experienced Mild COVID-19 Infection: A Scoping Review

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Clinical presentation and pulmonary function tests in post-acute COVID-19 patients

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