Heterotopic calcification following burns: a prospective study

Münster, Anna-Marie Bloch; Bruck, Heike; Johns, Lois A.; Prince, Kilulu Von; Kirkman, Emrys; Remig, Robert L.

doi:10.1097/00006534-197308000-00055

Cited by 14 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7,[13][14][15][16][17] Most nontraumatic models result in contractures which reverse to almost normal after remobilization. 12,[18][19][20] The combination of immobilization and trauma has been shown to promote a more permanent loss of motion. 7 The severity of the contracture after remobilization with current models is unlikely to allow meaningful comparisons if drug therapy were to be tested.…”

Section: Discussionmentioning

confidence: 99%

New rabbit knee model of posttraumatic joint contracture: Indirect capsular damage induces a severe contracture

Nesterenko

Morrey

Abdel

et al. 2009

Journal Orthopaedic Research

122

View full text Add to dashboard Cite

Reported models of joint contracture fail to result in severe motion loss. Our purpose was to develop a rabbit model of knee contracture and compare it to another well-accepted model to determine if more severe stiffness can be achieved. Sixteen skeletally mature New Zealand White female rabbits had their right knee operated to create 3-mm defects on the noncartilaginous portions of the femoral condyles, hyperextend the joint to disrupt the posterior capsule, and immobilize the joint in maximum flexion with a Kirschner-wire for 8 weeks (group I). Sixteen additional rabbits were operated on using an identical protocol except for the absence of capsular injury (group II). In each group, mechanical testing was performed at the time of Kirschner-wire release in eight animals, and 16 weeks after remobilization in eight animals. At immobilization release, the average contracture was 76 AE 248 in group I versus 20 AE 108 in group II (p < 0.001). Sixteen weeks after remobilization, the mean contracture was 49 AE 158 group I versus 11 AE 108 in group II (p < 0.001). When associated with bone perforations and immobilization in forced flexion, injury to the posterior capsule results in a severe contracture in the rabbit knee. ß

show abstract

Section: Discussionmentioning

confidence: 99%

New rabbit knee model of posttraumatic joint contracture: Indirect capsular damage induces a severe contracture

Nesterenko

Morrey

Abdel

et al. 2009

Journal Orthopaedic Research

122

View full text Add to dashboard Cite

show abstract

“…There was no correlation between development of HO and burn size or third-degree burn, but third-degree burns over or near the elbow were associated with a higher incidence. In a 1-year prospective study, Munster et al 17 followed the hospital course of 88 patients with 160 burned upper limbs. Twelve patients (13.6%) with 18 burned arms developed HO.…”

Section: Discussionmentioning

confidence: 99%

Heterotopic Ossification Revisited: A 21-Year Surgical Experience

Hunt

Arnoldo

Kowalske

et al. 2006

Journal of Burn Care & Research

View full text Add to dashboard Cite

Heterotopic ossification (HO) is an infrequently encountered complication of a burn. A retrospective review was undertaken to evaluate our treatment and results. Forty-two patients were identified with HO during 21 yrs. Mean age was 38 yrs. Mean total body surface area and third-degree burn were 55% and 37%, respectively. The elbow was the most frequent site (>90%), and 44% were bilateral. The next most common sites were shoulder, hip, knee, and forearm. Greater than 90% of patients had ventilator support and intensive care unit length of stay 58 and 79 days, respectively. HO was first suspected by decreased range of motion, painful and/or swollen joint, or a nerve deficit. Conventional radiographs were used to confirm the clinical diagnosis. The majority of burns overlying joints with HO were associated with prolonged wound closure because of depth, wound infection, or graft loss. Mean day of diagnosis was 71 days (range, 21-134). Excision of HO was undertaken only when range of motion compromised activities of daily living. Surgery successfully improved range of motion in all cases. The mean elbow arc of motion before and after surgery was 52 degrees and 119 degrees (range, 30-180 degrees), respectively. Seventy percent of elbows were ankylosed. A continuous passive motion device was instituted immediately postoperatively. Local postoperative complications included hematoma, wound dehiscence, infection, and nerve deficit. Maintaining range of motion was difficult for 75% of patients. Symptomatic recurrence of HO occurred in four elbows and one forearm. Because the cause(s) are unknown, prevention is impossible; once diagnosed, medical treatment is problematic and spontaneous resolution is infrequent. Surgery continues to be the recommended treatment when activities of daily living or life style are affected.

show abstract

“…Garland [28] empfiehlt ein Konzept, wonach eine Operation erfolgen sollte, wenn die "Ausreifung" der Ossifikationen durch eine Normalisierung der serumalkalischen Phosphatase verifiziert wurde. Die serumalkalische Phosphatase ist allerdings für Brandverletzte kein verlässlicher Parameter, da dieser Wert bei isolierter Lokalisation von Ossifikationen im Bereich der Ellenbogengelenke oft im Normbereich liegt [25]. Dieser Sachverhalt erklärt sich mit der Tatsache, dass bei ausschließlichem Befall der Ellenbogengelenke keine ausreichende Produktion von Knochengewebe vorliegt, um einen Anstieg der serumalkalischen Phosphatase hervorzurufen [28].…”

Section: > Am Häufigsten Sind Bei Brandverletzten Die Ellenbogengelenunclassified

“…Darü-ber hinaus wurde eine vermehrte Häu-fung für die Entwicklung von extraartikulären Neuformationen bei einer betroffenen Körperoberfläche von mehr als 20% beobachtet [22,23,24]. In der Literatur finden sich allerdings auch Verläufe mit periartikulären Ossifikationen bei Brandverletzungen mit einer geringergradigen Verletzungsschwere [9,18,20,25].…”

Section: Introductionunclassified

Heterotope Ossifikationen bei Schwerbrandverletzten

Siemers

et al. 2010

Chirurg

View full text Add to dashboard Cite

Heterotopic ossifications in peri-articular tissue can appear after severe head injury, spinal trauma or local joint trauma. Following extensive burns, heterotopic ossifications are a rare, but severe complication with an unknown pathogenesis. In a retrospective analysis of 672 patients who were treated in our burn center over the last 10 years we identified 5 cases (0.74%) of heterotopic ossification.

show abstract

Heterotopic calcification following burns: a prospective study

Cited by 14 publications

References 0 publications

New rabbit knee model of posttraumatic joint contracture: Indirect capsular damage induces a severe contracture

New rabbit knee model of posttraumatic joint contracture: Indirect capsular damage induces a severe contracture

Heterotopic Ossification Revisited: A 21-Year Surgical Experience

Heterotope Ossifikationen bei Schwerbrandverletzten

Contact Info

Product

Resources

About