Heterylgermatranes

Abstract

Germatranes containing a heterocyclic substituent (furyl, thienyl) bond to the germatrane ring directly or by the means of methylene and siloxy(germoxy) groups have been synthesized.Intramolecular N-*Ge interaction in these compounds has been proved by El, CI and FAB mass-spectroscopic and X-Ray structural investigations.The results of biological investigations indicate that all heterylgermatranes are less toxic than the corresponding silatranes, the toxicity decreases by insertion of carbon or heteroatoms between heterocycle and germatrane ring, the neurotropic activity depends on the position of substituent in the heterocyclic ring.

Neurotropic and antitumor activities of silyl- and germyl-isoxazolin-2-yl derivatives

“…1 Germanium-containing heterocycles are usually less toxic than their carbon and silicon analogues. [2][3][4] We have performed a comparative study of the vasodilating, anticoagulant and cardioprotective activity of 5-Si(Ge)-substituted isoxazolin-2-yl derivatives. The substitution of the silicon atom for the germanium does indeed lead to a significant increase in vasodilating, antithrombotic and cardioprotective activity.…”