HfO₂‐CoO nanoparticles for electrochemical dopamine sensing

Abstract

Dopamine (DA) is a neurotransmitter that plays a pivotal role in the brain's proper functioning and several other physiological processes. Herein, we demonstrate the miniaturized electrochemical sensor for detecting DA using hafnium metal-organic framework (Hf-MOF) derived new nanocomposite of hafnium and cobalt oxides (HfO 2 -CoO). Calcination of Hf-MOF coated with cobalt acetylacetonate complex [(Co(acac) 2 ] yield HfO 2 -CoO nanoparticles supported over in situ generated graphitic carbon. The excellent adsorption capabilities of HfO 2 and highly catalytic CoO activity make this bimetallic HfO 2 -CoO nanocomposite to display a stable response over a wide linear concentration range when used as electrode material in the electrochemical DA sensing process. Moreover, the computational study also proves that CoO improves the chemisorption properties of HfO 2 for DA. Electrochemical studies are performed through cyclic voltammetry (CV), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV). For the case of LSV, the HfO 2 -CoO nanocomposite modified glassy carbon electrode (HfO 2 -CoO/GCE) exhibit a linear response to DA concentration ranging from 0.25 to 3.15 mM. However, with DPV HfO 2 -CoO/GCE electrode has displayed a linear range of 10-190 μM and a detection limit of 1.8 μM is achieved. The electrode has also shown excellent stability, and only 19 % loss in its initial current response is observed over 150 days of specific interval testing.The HfO 2 -CoO/GCE nanocomposite electrode, due to its unique feature of stability, selectivity, and sensitivity, has a good potential for use as an analytical tool for non-enzymatic sensing of DA and other neurotransmitters in the human fluid.

MXene‐Coated Liposome‐Quercetin‐Functionalized Gold Nanoparticles for Electrochemical Detection of Dopamine

“…Therefore, electrochemical methods have been developed to achieve reasonable sensitivity and selectivity for DA by using divergent materials, including fullerenes (0D), carbon nanotubes (1D), reduced graphene oxide (rGO) (2D), and metal-organic frameworks (3D). [8][9][10][11][12][13] Nanoparticle (NP)-based electrochemical detection is an indispensable strategy owing to its excellent catalytic activity and large surface area. Among the various NPs, metal-derived NPs are highly conductive, with potential catalytic features.…”

“…Therefore, electrochemical methods have been developed to achieve reasonable sensitivity and selectivity for DA by using divergent materials, including fullerenes (0D), carbon nanotubes (1D), reduced graphene oxide (rGO) (2D), and metal–organic frameworks (3D). [ 8–13 ]…”