Dopamine (DA) is a neurotransmitter that plays a pivotal role in the brain's proper functioning and several other physiological processes. Herein, we demonstrate the miniaturized electrochemical sensor for detecting DA using hafnium metal-organic framework (Hf-MOF) derived new nanocomposite of hafnium and cobalt oxides (HfO 2 -CoO). Calcination of Hf-MOF coated with cobalt acetylacetonate complex [(Co(acac) 2 ] yield HfO 2 -CoO nanoparticles supported over in situ generated graphitic carbon. The excellent adsorption capabilities of HfO 2 and highly catalytic CoO activity make this bimetallic HfO 2 -CoO nanocomposite to display a stable response over a wide linear concentration range when used as electrode material in the electrochemical DA sensing process. Moreover, the computational study also proves that CoO improves the chemisorption properties of HfO 2 for DA. Electrochemical studies are performed through cyclic voltammetry (CV), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV). For the case of LSV, the HfO 2 -CoO nanocomposite modified glassy carbon electrode (HfO 2 -CoO/GCE) exhibit a linear response to DA concentration ranging from 0.25 to 3.15 mM. However, with DPV HfO 2 -CoO/GCE electrode has displayed a linear range of 10-190 μM and a detection limit of 1.8 μM is achieved. The electrode has also shown excellent stability, and only 19 % loss in its initial current response is observed over 150 days of specific interval testing.The HfO 2 -CoO/GCE nanocomposite electrode, due to its unique feature of stability, selectivity, and sensitivity, has a good potential for use as an analytical tool for non-enzymatic sensing of DA and other neurotransmitters in the human fluid.