Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans

Abstract

Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease. Our previous report suggested that Hibiscus sabdariffa extracts (HSE) had a metabolic-regulating and liver-protecting potential. In this study, we performed a clinical trial to further confirm the effect of HSE. Subjects with a BMI ≧ 27 and aged 18-65, were randomly divided into control (n = 17) and HSE-treated (n = 19) groups, respectively, for 12 weeks. Our data showed that consumption of HSE reduced body weight, BMI, body fat and the waist-to-hip ratio. Serum free fatty acid (FFA) was lowered by HSE. Anatomic changes revealed that HSE improved the illness of liver steatosis. Ingestion of HSE was well tolerated and there was no adverse effect during the trial. No alteration was found for serum α-amylase and lipase. The clinical effect should mainly be attributed to the polyphenols of HSE, since composition analysis showed that branched chain-amino acids, which is associated with obesity, is not obviously high. In conclusion, consumption of HSE reduced obesity, abdominal fat, serum FFA and improved liver steatosis. HSE could act as an adjuvant for preventing obesity and non-alcoholic fatty liver.

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

“…So far, data on the beneficial effect of compounds of plant origin regarding the effect of Cd on the liver have derived mainly from animal models and in vitro studies. However, the well‐established effectiveness of these products in the prevention and therapy of various diseases in humans (Boncheva, Georgiev, & Shishov, ; Bozzetto et al, ; Chang, Peng, Yeh, Kao, & Wang, ; Henning et al, ; Hokayem et al, ; Ni et al, ; Pezeshki, Safi, Feizi, Askari, & Karami, ; Rasines‐Perea & Teissedre, ; Soleimani, Paknahad, Askari, Iraj, & Feizi, ; Tresserra‐Rimbau et al, ; Venancio et al, ) allows to suppose that these plant ingredients may also be effective in the prevention and treatment of liver injury caused by this toxic metal. Owing to the multidirectional beneficial properties of polyphenols, these compounds seem to be the most promising substances when considering the possible effective agents to counteract and treat Cd hepatotoxicity.…”

Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension

“…One of them is Hibiscus sabdariffa Linn. -a member of the Malvaceae family -commonly used due to its cardioprotective properties in experimental and clinical studies [4][5][6][7]. Hibiscus sabdariffa is used in many countries as a food, cold and hot beverages, wine, jam, and ice cream, chocolates, as a flavoring agent in the food industry, and as a medicinal herb [8].…”

DETERMINAÇÃO DO TEOR DE FENÓLICOS TOTAIS DO Hibiscus sabdariff EMPREGANDO EXTRAÇÃO HIDROETANÓLICA.

“…Os compostos bioativos possuem propriedades medicinais que atuam como anti-inflamatórios e na prevenção do câncer (Chang et al, 2014;Zhen et al,2016).…”