Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity

Samuel, Anbu Jeba Sunilson John; Mohan, Syam; Chellappan, Dinesh Kumar; Kalusalingam, Anandarajagopal; Ariamuthu, Saraswathi

doi:10.1016/j.jep.2012.02.051

Cited by 36 publications

(23 citation statements)

References 39 publications

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“…Increased lipid peroxidation and reduced SOD, Catalase and GSH suggested oxidative damage in hepatocytes. This caused damaged to the structural and functional integrity of the liver cells, significantly increased hepatocellular enzymes, as previously described [14]. In the present investigation the total recovery of liver injury was observed after treatment with aqueous and ethanolic extract of OI whole stem.…”

Section: Il6 Mrna Expressionsupporting

confidence: 85%

Oroxylum indicum (Linn.) whole stem extract regulates expression of TNFα, IL6, NFkB, P38 MAPK and oxidative status in antitubercular therapy induced hepatotoxicity in Wistar rats

More¹,

Shah²,

Parab³

et al. 2017

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The objective of the present study is to assess the hepatoprotective activity of Oroxylum indicum Linn. (OI) whole stem extract on antitubercular drug induced liver toxicity in rats. Hepatotoxicity was induced by oral dosing of the combination of antitubercular drugs viz. AKT-4 for 90 days to Wistar rats. After assessing the hepatotoxicity in the animals, treatment with both aqueous and ethanolic whole stem extracts of Oroxylum indicum Linn. (OI) as well as standard marketed drug was done for 30 days. At the end of 30 days the hepatoprotective activity of OI was assessed using serum markers for liver dysfunction and expression of antioxidant enzymes in the liver tissue. Histopathological assessment and mRNA expression profiles for TNFα, IL6, NFkB, P38 MAPK was carried out to evaluate the protection of liver against antitubercular drugs by the extracts. Both the aqueous and ethanolic extracts of OI significantly (p<0.05) restored the serum enzyme levels. Also the various tissue antioxidant enzymes were also restored compared to normal group. Histopathological evaluations showed absence of any remarkable pathological and metabolic changes in the liver sections of treated groups. mRNA expression was significantly increased in disease induced group as compared to normal control. Treatment with extract significantly reduced cytokines and P38 MAPK mRNA expressions.

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Section: Il6 Mrna Expressionsupporting

confidence: 85%

Oroxylum indicum (Linn.) whole stem extract regulates expression of TNFα, IL6, NFkB, P38 MAPK and oxidative status in antitubercular therapy induced hepatotoxicity in Wistar rats

More¹,

Shah²,

Parab³

et al. 2017

Matters

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“…All chemical agents first pass through liver prior to enter in blood circulation. So liver is at high risk of damage then other body organ (Samuel et al, 2012). The toxic agents which may damage the liver are drugs such as paracetamol, xenobiotics, viral infections, alcoholism and chemical agents (Ramchandara et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…So there is an urgent need to investigate the natural plants and isolate their constituents which can be beneficial to control liver diseases (Ravikumar et al, 2012). It has been seen that many herbal plants are found to be hepatoprotective such as Cichorium intybus (Heibatollah et al, 2008), Luminet racemosa (Gnanadesigan et al, 2011), Solanum nigrum (Raju et al, 2003), Hibiscus vitifolius (Samuel et al, 2012), Chenopodium murale (Saleem et al, 2014), Trichodesma sedgwickianum (Saboo et al, 2013), Oflpomoea staphylina (Bag and Mumtaz, 2013), Convolvulus arvensis (Ali et al, 2013), Suaeda fruticosa (Rehman et al, 2013) and Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala .…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of aqeous methanolic extract of <i>Rumex dentatus</i> in paracetamol induced hepatotoxicity in mice

Saleem

Ahmed²,

Karim³

et al. 2014

Bangladesh J Pharmacol

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Rumex dentatus is well known plant of Polygonaceae family which is widely used in traditional medicine to treat gastrointestinal tract. R. dentatus at doses 250 and 500 mg/kg significance decreased (p<0.001) the elevated level of ALT, AST, ALP and bilirubin induced by paracetamol and results are comparable (p<0.001) with silymarin. The results were supported by histopathological investigations, phytochemical screening and detection of hepatoprotective active constituents e.g quercetin, kaempferol, myricetin by HPLC. So, it is concluded that R. dentatus has hepatoprotective effect against paracetamol liver damage in mice. Article InfoReceived:12

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“…The liver is one of the vital organs of the body and plays a key role in the metabolism and detoxification process; disorders of this organ remain some of the most serious health problems [1] . Drug-induced hepatic injury is considered as the primary cause of hepatotoxicity [2] .…”

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confidence: 99%

Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

Reddy¹

2017

ijps

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Anudeep, et al.: Green Tea (Camellia sinensis) in HepatotoxicityAn experimental study was conducted to evaluate the hepatoprotective effect of aqueous extract of Camellia sinensis or green tea extract and N-acetyl-L-cysteine in acetaminophen-induced hepatotoxicity in rats. Male Wistar rats (n=24) of 3 mon age were equally divided into 4 groups. Group 1 served as normal control. Hepatotoxicity was induced in the remaining three groups with oral administration of 500 mg/kg of acetaminophen from day 1 to day 3. Groups 2, 3 and 4 were subsequently administered orally with distilled water, 300 mg/kg of N-acetyl-L-cysteine and 100 mg/kg green tea extract, respectively for 11 d. Mean body weights and biomarkers of hepatotoxicity were estimated on days 0, 4 (confirmation of toxicity) 15 (at the end of treatment). Hematological parameters were evaluated on 4 and 15 d. Antioxidant profile and ATPase enzymes were assessed at the end of the experiment. Livers were subjected to histopathology and transmission electron microscopy after the sacrifice on day 15. Antioxidant profile, ATPase, haematological and serobiochemical parameters were significantly altered and histopathological changes were noticed in liver of toxic control group. These changes were reversed in groups 3 and 4 that were administered with N-acetyl-L-cysteine and green tea extract, respectively. The results of the present investigation enunciated that green tea extract has potent hepatoprotective activity, though N-acetyl-L-cysteine was found superior in restoring the pathological alterations in acetaminophen-induced hepatotoxicity in Wistar rats.

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Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity

Cited by 36 publications

References 39 publications

Oroxylum indicum (Linn.) whole stem extract regulates expression of TNFα, IL6, NFkB, P38 MAPK and oxidative status in antitubercular therapy induced hepatotoxicity in Wistar rats

Oroxylum indicum (Linn.) whole stem extract regulates expression of TNFα, IL6, NFkB, P38 MAPK and oxidative status in antitubercular therapy induced hepatotoxicity in Wistar rats

Hepatoprotective effect of aqeous methanolic extract of <i>Rumex dentatus</i> in paracetamol induced hepatotoxicity in mice

Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

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