High amylose starch consumption induces obesity in Drosophila melanogaster and metformin partially prevents accumulation of storage lipids and shortens lifespan of the insects

Abrat, Oleksandra B.; Storey, Janet M.; Storey, Kenneth B.; Lushchak, Volodymyr I.

doi:10.1016/j.cbpa.2017.10.011

Cited by 25 publications

(25 citation statements)

References 41 publications

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“…In Drosophila, administration of metformin caused activation of AMPK and reduced the weight of adipose tissue; however, the drug did not prolong lifespan [24]. Long-term intake of metformin with a starch-supplemented diet shortened the lifespan of Drosophila melanogaster compared to in the group fed the starch-supplemented diet alone [25]. In C57BL/6 mice administered two doses of metformin (0.1% and 1%), the survival rate was significantly reduced at a higher dose compared to in the control; however, at a lower dose, the survival rate significantly increased, even when the mice consumed more feed [26].…”

Section: Calorie Restriction Mimeticsmentioning

confidence: 97%

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Shintani¹,

Shintani²,

Ashida³

et al. 2018

Preprint

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Calorie restriction (CR) has been shown to prolong the lifespan of humans, but enforcing long-term CR is difficult. Therefore, a compound that reproduces the effect of CR without CR is needed. In this review, we summarize the current knowledge on compounds with CR mimetic (CRM) effects. More than 10 compounds have been listed as CRMs, some of which are conventionally categorized as upstream-type CRMs showing glycolytic inhibition while the others are categorized as downstream-type CRMs that regulate or genetically modulate intracellular signaling proteins. Among these, we focus on upstream-type CRMs and propose their classification as compounds with energy metabolism inhibition effects, particularly glucose metabolism modulation effects. The upstream-type CRMs reviewed include chitosan, acarbose, sodium-glucose cotransporter 2 inhibitors, and hexose analogs such as 2-deoxy-D-glucose, D-glucosamine, and D-allulose, which show anti-aging and longevity effects. Finally, we discuss the molecular definition of upstream-type CRMs.

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Section: Calorie Restriction Mimeticsmentioning

confidence: 97%

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Shintani¹,

Shintani²,

Ashida³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the use of CRMs does not always result in longevity extension. For instance, metformin, a well-known antidiabetic drug that triggers the activation of the nutrient sensor AMPKα and induces fat burn in the adipose tissue, does not confer lifespan elongation [111]. Administration of the Tor inhibitor rapamycin, known for its immunosuppressant properties, extends in a sex-dependent manner the lifespan of Drosophila flies with impaired energy regulation fed on a regular diet [112, 113].…”

Section: The Effects Of Distinct Nutritional Interventions On Healthymentioning

confidence: 99%

Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach

et al. 2019

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Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions. This process is affected by both genetic and environmental (e.g., diet) factors, as well as by their constant interaction. Consistently, deregulation of nutrient sensing and signaling pathways is considered a hallmark of aging. Nutrigenomics is an emerging scientific discipline that studies changes induced by diet on the genome and thus it considers the intersection of three topics, namely health, diet, and genomics. Model organisms, such as the fruit fly Drosophila melanogaster , have been successfully used for in vivo modeling of higher metazoans aging and for nutrigenomic studies. Drosophila is a well-studied organism with sophisticated genetics and a fully annotated sequenced genome, in which ~ 75% of human disease-related genes have functional orthologs. Also, flies have organs/tissues that perform the equivalent functions of most mammalian organs, while discrete clusters of cells maintain insect carbohydrate homeostasis in a way similar to pancreatic cells. Herein, we discuss the mechanistic connections between nutrition and aging in Drosophila , and how this model organism can be used to study the effect of different diets (including natural products and/or their derivatives) on higher metazoans longevity. Electronic supplementary material The online version of this article (10.1186/s12263-019-0638-6) contains supplementary material, which is available to authorized users.

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“…In Drosophila , administration of metformin caused activation of AMPK and reduced the weight of adipose tissue; however, the drug did not prolong lifespan [24]. Long-term intake of metformin with a starch-supplemented diet shortened the lifespan of Drosophila melanogaster compared to the group fed the starch-supplemented diet alone [25]. In C57BL/6 mice administered two doses of metformin (0.1% and 1%), the survival rate was significantly reduced at a higher dose compared to in the control; however, at a lower dose, the survival rate significantly increased, even when the mice consumed more feed [26].…”

Section: Calorie Restriction Mimeticsmentioning

confidence: 99%

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Shintani¹,

Shintani

Ashida

et al. 2018

Nutrients

View full text Add to dashboard Cite

Calorie restriction (CR) can prolong the human lifespan, but enforcing long-term CR is difficult. Therefore, a compound that reproduces the effect of CR without CR is needed. In this review, we summarize the current knowledge on compounds with CR mimetic (CRM) effects. More than 10 compounds have been listed as CRMs, some of which are conventionally categorized as upstream-type CRMs showing glycolytic inhibition, while the others are categorized as downstream-type CRMs that regulate or genetically modulate intracellular signaling proteins. Among these, we focus on upstream-type CRMs and propose their classification as compounds with energy metabolism inhibition effects, particularly glucose metabolism modulation effects. The upstream-type CRMs reviewed include chitosan, acarbose, sodium-glucose cotransporter 2 inhibitors, and hexose analogs such as 2-deoxy-d-glucose, d-glucosamine, and d-allulose, which show antiaging and longevity effects. Finally, we discuss the molecular definition of upstream-type CRMs.

show abstract

High amylose starch consumption induces obesity in Drosophila melanogaster and metformin partially prevents accumulation of storage lipids and shortens lifespan of the insects

Cited by 25 publications

References 41 publications

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

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