High-aspect ratio submicrometer needles for intracellular applications

Hanein, Yael; Schabmueller, C G J; Holman, Gordon D.; Lücke, Peter; Denton, Denice D.; Böhringer, K. F.

doi:10.1088/0960-1317/13/4/315

Cited by 58 publications

(46 citation statements)

References 10 publications

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“…Sharp, microfabricated silicon needles with flexible polyimide-based connection have been developed for intracellular recording and tested in moths and sea slugs (Hanein et al, 2002(Hanein et al, , 2003. These high-aspect probes have submicrometer diameters.…”

Section: Other Silicon-based Arraysmentioning

confidence: 99%

Implantable microscale neural interfaces

Cheung

2007

Biomed Microdevices

190

175

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Implantable neural microsystems provide an interface to the nervous system, giving cellular resolution to physiological processes unattainable today with non-invasive methods. Such implantable microelectrode arrays are being developed to simultaneously sample signals at many points in the tissue, providing insight into processes such as movement control, memory formation, and perception. These electrode arrays have been microfabricated on a variety of substrates, including silicon, using both surface and bulk micromachining techniques, and more recently, polymers. Current approaches to achieving a stable long-term tissue interface focus on engineering the surface properties of the implant, including coatings that discourage protein adsorption or release bioactive molecules. The implementation of a wireless interface requires consideration of the necessary data flow, amplification, signal processing, and packaging. In future, the realization of a fully implantable neural microsystem will contribute to both diagnostic and therapeutic applications, such as a neuroprosthetic interface to restore motor functions in paralyzed patients.

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Section: Other Silicon-based Arraysmentioning

confidence: 99%

Implantable microscale neural interfaces

Cheung

2007

Biomed Microdevices

190

175

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“…In order to avoid it, Hanein et al [11] proposed the idea of protecting a main pillar with surrounding sacrificial structures, in a way that they would obstruct the plasma coupling to the bottom of the main electrode and thus avoid the underetch. They also used a second etching step to sharpen the main pillars and get rid of the sacrificial structures; the latter happens naturally as a consequence of the etching process.…”

Section: A Plasma Etchingmentioning

confidence: 99%

Three dimensional electrochemical system for neurobiological studies

Vázquez

Svendsen

2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-In this work we report a novel three dimensional electrode array for electrochemical measurements in neuronal studies. The main advantage of working with these out-of-plane structures is the enhanced sensitivity of the system in terms of measuring electrochemical changes in the environment of a cell culture in real time. In addition, the system is devised to offer a compact solution that helps to obtain a homogeneous distribution of current density among the active electrodes.

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“…Microstructures with sharp tips are playing increasingly important roles in many fields, such as probes used in scanning probe microscopy (SPM) [1] and nanolithography [2], microelectrodes used in the neural interfacing [3] and chemical/biological sensing [4,5], microneedles used in drug injection [6], probes in field emission [7] and data storage [8], and so on. These microstructures have many obvious advantages: (1) fine resolution, (2) small invasive effects which are required in many sensing fields, and (3) easy penetration and arrival at the aim points [9].…”

Section: Introductionmentioning

confidence: 99%