High‐definition optical coherence tomography algorithm for the discrimination of actinic keratosis from normal skin and from squamous cell carcinoma

Boone, Marc; Marneffe, A.; Suppa, Mariano; Miyamoto, Makiko; Alarcón, Ivette; Hofmann‐Wellenhof, Rainer; Malvehy, Josep; Pellacani, Giovanni; Marmol, Véronique Del

doi:10.1111/jdv.12954

Cited by 51 publications

(72 citation statements)

References 39 publications

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“…A positive value of this optical parameter correlated with the absence of an outlined DEJ on cross‐sectional mode. The absence of an outlined DEJ was a highly sensitive morphological feature for SCC . However, in that study, 14% of AKs also showed a non‐outlined DEJ lowering the specificity for SCC considerably.…”

Section: Discussionmentioning

confidence: 93%

“…Based on these features, an algorithm was created (Fig. ), which ultimately leads to seven diagnostic categories previously described …”

Section: Resultsmentioning

confidence: 99%

“…High‐definition optical coherence tomography (HD‐OCT) is a recently introduced non‐invasive imaging technique . It combines cellular resolution and 3D imaging up to the superficial reticular dermis.…”

Section: Introductionmentioning

confidence: 99%

“…It combines cellular resolution and 3D imaging up to the superficial reticular dermis. Select 3D HD‐OCT features seem to have the potential to discriminate SCC from AK and normal skin, thus HD‐OCT could be regarded as an important second‐level diagnostic tool, able to spare patients unnecessary excisions . However, the diagnostic performance is clearly associated with the level of experience …”

Section: Introductionmentioning

confidence: 99%

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A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high‐definition optical coherence tomography

Boone

Suppa

Marneffe

et al. 2016

Acad Dermatol Venereol

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HD-OCT seems to enable the combination of in vivo morphological analysis of cellular and 3D microarchitectural structures with in vivo analysis of optical properties of tissue scatterers in AK/SCC lesions and normal sun-exposed skin. In vivoHD-OCT analysis of optical properties permits AK discrimination from SCC and AK subdifferentiation with higher accuracy than in vivoHD-OCT analysis of morphology alone.

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Section: Discussionmentioning

confidence: 93%

“…Based on these features, an algorithm was created (Fig. ), which ultimately leads to seven diagnostic categories previously described …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high‐definition optical coherence tomography

Boone

Suppa

Marneffe

et al. 2016

Acad Dermatol Venereol

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“…OCT may have a lower resolution compared to RCM but it can provide realtime imaging to detect gross alteration in skin structure that can be easily correlated to conventional histopathology (Figure 1.5). Others have also demonstrated that OCT has potential to discriminate benign from malignant skin lesions (Gambichler et al, 2007, Boone et al, 2015. This may be one explanation for the rapid gain of popularity of this technology for clinical diagnostics.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

The skin microbiopsy

Lin¹

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Skin cancer is reported to incur the highest treatment costs of all cancers. The treatment cost of non-melanoma skin cancer (NMSC) was purported to be around AUD$264 million, and AUD$30 million for melanoma in 2001. Conventional skin biopsy techniques are performed to identify histopathological signs of malignancy. Suspicious lesions are often present on cosmetically sensitive areas and may be present in large numbers, making biopsies unfeasible. As a result, many atypical lesions are left untreated (leaving patients with early cancerous lesions) or needlessly removed (unnecessary scars). Prognostic biomarkers are useful for assessing borderline cases to facilitate early detection of skin cancer. The development of a novel microbiopsy device (Figure 1.1) from this Thesis enables quick, simple, minimally invasive and suture-free sampling of tiny skin samples sufficient for molecular assays.Laser cutting technologies have enabled rapid prototyping of microbiopsy devices made from medical-grade stainless steel. Through optimisation of the laser parameters, a twodimensional microbiopsy that assembles to form a three-dimensional cutting tip with a hallow chamber was successfully constructed. A quick and safe method to facilitate repeated collection over time in human patients is now possible with the microbiopsybased approach.Characterisation studies revealed approximately 1000 to 3000 cells from each velocityaided microbiopsy with an average DNA and RNA yield of 5.9 ± 3.4 ng and 9.0 ± 10.1 ng, respectively. Human volunteer studies have shown that the microbiopsy application ii velocity, channel width, edge surface roughness and geometries were important aspects to achieve reproducible tissue sampling.Genomic profiling of an individual can now be done using microbiopsy sampling approach instead of conventional blood or saliva samples. The limitation of small sample size can be overcome by using high-fidelity amplification technologies for amplifying nucleic acids. The defects left by microbiopsy application observed in histopathological sections were similar to artefacts arising from routine tissue processing. This opens up opportunities for the possibility of in vivo sampling and enables molecular diagnosis without the risk of damaging the lesion -which will help to improve patient care by reducing unnecessary excision. Proof-of-concept studies have established the potential of the guided skin microbiopsy device to study in vivo molecular changes within a targeted area over time, which was impossible in the past.Other than clinical applications, the microbiopsy device also offers a novel approach for live cell assays. Current approaches, in particular those related to the cosmeceutical arena are limited to restrictive regulations on animal testing, and the fact it is often not deemed ethical or practical to use conventional biopsy techniques to assess the effect of cosmetics. One debatable topic in this arena is the likelihood of nanoparticles to infiltrate the viable epidermis and cause cell toxicity. Human...

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Optical coherence tomography for diagnosing skin cancer in adults

Ruffano

Dinnes

Deeks

et al. 2018

Cochrane Database of Systematic Reviews

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Background Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Optical coherence tomography (OCT) is a microscopic imaging technique, which magnifies the surface of a skin lesion using near-infrared light. Used in conjunction with clinical or dermoscopic examination of suspected skin cancer, or both, OCT may offer additional diagnostic information compared to other technologies. Objectives To determine the diagnostic accuracy of OCT for the detection of cutaneous invasive melanoma and atypical intraepidermal melanocytic variants, basal cell carcinoma (BCC), or cutaneous squamous cell carcinoma (cSCC) in adults.

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High‐definition optical coherence tomography algorithm for the discrimination of actinic keratosis from normal skin and from squamous cell carcinoma

Cited by 51 publications

References 39 publications

A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high‐definition optical coherence tomography

A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high‐definition optical coherence tomography

The skin microbiopsy

Optical coherence tomography for diagnosing skin cancer in adults

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