High-dose vitamin D after lung transplantation: A randomized trial

Vos, Robin; Ruttens, David; Verleden, Stijn E.; Vandermeulen, Elly; Bellon, Hannelore; Herck, Anke Van; Sacreas, Annelore; Heigl, Tobias; Schaevers, Veronique; Raemdonck, Dirk Van; Verbeken, Eric; Neyrinck, Arne; Dupont, Lieven; Yserbyt, Jonas; Vanaudenaerde, Bart M.; Verleden, Geert M.

doi:10.1016/j.healun.2017.03.008

Cited by 28 publications

(31 citation statements)

References 30 publications

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“…The association substantially attenuates for later time points. Although preliminary trials have yielded negative results in other transplant populations, it remains to be investigated whether vitamin D supplementation therapy among deficient KT recipients could ameliorate the susceptibility to infectious complications.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and infection risk in kidney transplant recipients: A single‐center cohort study

Fernández‐Ruiz

Corbella

Morales-Cartagena

et al. 2018

Transplant Infectious Dis

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and infection risk in kidney transplant recipients: A single‐center cohort study

Fernández‐Ruiz

Corbella

Morales-Cartagena

et al. 2018

Transplant Infectious Dis

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“…27 25-OH-vitamin D levels showed a significant 28 In the third National Health and Nutrition Examination Survey, 29 a strong relationship between serum concentrations of 25-OH-vitamin D, FEV1 (L), and FVC (L) was described, but this study did not examine CF patients. Vitamin D has also been associated with the strength of muscles.…”

Section: Discussionmentioning

confidence: 86%

Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis

et al. 2018

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Background: Nutritional status is an important prognostic factor in patients with cystic fibrosis (CF) prior to lung transplantation. Objective: To investigate the impact of nutritional status on pulmonary function in CF transplant recipients. Methods: Adult double lung transplanted CF patients were consecutively included. The predictive value of nutritional status on lung function -measured by spirometry -was longitudinally assessed by body composition serially evaluated by a threecompartment model bioelectrical impedance analysis (BIA) in comparison to body mass index (BMI). Results: Overall, 147 spirometries and 147 BIAs were performed in 58 patients (59% female, median age: 30.1 years, median BMI: 19.6 kg/m 2 ). Malnourished patients (BMI < 18.5 kg/m 2 ; 27.6%) had a significantly reduced lung function compared to normal/overweight patients (forced expiratory volume in 1 second in percent (FEV1%pred), 57% vs 77%; p ¼ 0.024). BMI, as well as the BIA parameters phase angle, total body water, fat free mass, body cell mass (BCM) and extracellular mass (ECM)/ BCM ratio, were univariate predictors of FEV1%pred. When included in a linear mixed model, ECM/BCM ratio remained the only significant predictor of lung function (p ¼ 0.012). Conclusion: Nutritional status assessed by BIA predicted lung function in CF transplant recipients. Serial BIA measurements to monitor patients' nutritional status might help to improve or maintain lung function. KeywordsCystic fibrosis, lung transplantation, bioelectrical impedance analysis, body mass index, pulmonary function Received: 26 January 2018; accepted: 25 April 2018 Key summary . Nutritional status is a key prognostic factor of lung function and survival in patients with cystic fibrosis (CF) prior to lung transplantation, but data are limited on its impact on lung function after transplantation. . This study used serial measurements of body composition by a three-compartment model bioelectrical impedance analysis (BIA) in comparison to body mass index in order to analyse its impact on pulmonary function in adult CF transplant recipients.

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Section: Methodsmentioning

confidence: 99%

“…Recipient and donor selection criteria and management have been described previously and have not changed over time with respect to M abscessus infection. Standard induction and maintenance immunosuppression was given regardless of NTM infection . After pneumonectomy of the explant lung, the pleural cavity and surgical incision of every recipient is thoroughly rinsed and mechanically brushed with a povidone‐iodine antiseptic solution.…”

Section: Methodsmentioning

confidence: 99%

“…Standard induction and maintenance immunosuppression was given regardless of NTM infection. 5 After pneumonectomy of the explant lung, the pleural cavity and surgical incision of every recipient is thoroughly rinsed and mechanically brushed with a povidone-iodine antiseptic solution. In patients infected with M abscessus this was done even more rigorously and repeated three to 4 times.…”

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confidence: 99%

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Successful lung transplantation for chronic Mycobacterium abscessus infection in advanced cystic fibrosis, a case series

Raats

Lorent

Saegeman

et al. 2019

Transplant Infectious Dis

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Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra‐indication for lung transplantation in most centers. We present four CF patients with chronic pulmonary M abscessus infection, in whom lung transplantation was performed. Through intensive treatment before transplantation, we achieved control of the infection in all but one patient. After a mean of 16 months of follow up, 3 patients are doing well, without evidence of local or disseminated recurrence. One patient died early post‐transplant due to an unrelated cause. These findings support the possibility of lung transplantation with favorable outcome in CF patients with M abscessus infection.

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High-dose vitamin D after lung transplantation: A randomized trial

Cited by 28 publications

References 30 publications

Vitamin D deficiency and infection risk in kidney transplant recipients: A single‐center cohort study

Vitamin D deficiency and infection risk in kidney transplant recipients: A single‐center cohort study

Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis

Successful lung transplantation for chronic Mycobacterium abscessus infection in advanced cystic fibrosis, a case series

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