High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients

Song, Zhao; Ma, Wenjie; Zhang, Minghui; Tang, Dabei; Shi, Qingli; Xu, Shanqi; Zhang, Xiaosan; Liu, Yupeng; Song, Ying; Liu, Leyuan; Zhang, Qingyuan

doi:10.1007/s12032-012-0335-4

Cited by 77 publications

(70 citation statements)

References 29 publications

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“…Positive expression of MMP-2 and MMP-9 in tumor cells plays a vital role in their migration and invasion in vivo (26). MMP-9 is especially noted for decomposing the collagenous component of the ECM and devastating basic construction of collagen networks, thereby facilitating local invasion and distant migration (27).…”

Section: Discussionmentioning

confidence: 99%

Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions

Yan

Liu

et al. 2013

Bone Res.

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and bone tissues are the most frequent sites for metastases. Up to 70% of patients with metastatic breast cancer develop bone metastases that induce increased osteoclast activity, resulting in local bone destruction and skeletal complications, including pain, hypercalcemia, and nerve compression (1-3). The development and outgrowth of these secondary lesions rely upon the Wei Yan et al. www.boneresearch.org | Bone Research 363intricate cellular and molecular interactions between mammary tumor cells in the bone microenvironment. Tumor cells secrete signaling proteins, such as parathyroid hormone-related peptide (PTHrP) (4), to promote the secretion of RANKL, the receptor activator of nuclear factor-κB ligand, in osteoblast cells that activates bone osteolysis induced by osteoclasts. The concomitant bone destruction releases various growth factors, including transforming growth factor-β (TGF-β) and insulin-like growth factor-1 (IGF-1), to further bind the receptors on the surface of tumor cells and enhance cell proliferation and PTHrP production through activation of the Smad/ MAPK signaling transduction pathways, thus establishing a vicious cycle of bone metastases (5). The most widely used treatments in skeletal complications of varied neoplastic diseases are bisphosphonates (BPs) that block osteoclast activity; this application has been effective in decreasing formation of bone lesions, although this strategy fails to induce the bone regeneration (6). Furthermore, a growing number of case reports have demonstrated that long-term BP therapy might lead to osteonecrosis of the jaw (ONJ) (7-10). Therefore, the search for treatment options that can effectively inhibit tumor growth and reduce bone destruction caused by tumor metastases with mitigated side effects is of pivotal significance.Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), derived from the roots of the medical plant plumbago zeylanica, is one of the most investigated compounds. Recent studies have reported the antibacterial effects (11), anti-inflammatory effects (12), and anticancer activities of plumbagin both in vitro (13) and in vivo (14)(15). Previous studies have shown that plumbagin can inhibit tumor cell proliferation in vitro by inducing apoptosis and autophagy of breast neoplasm cells (13) and the invasion of prostate cancer cells (14). Recent studies have also demonstrated that plumbagin can inhibits osteoclastogenesis and reduces human breast cancerinduced osteolytic bone metastasis (16-18), however, more in vivo evidence need to be supplemented and the relevant mechanisms still remain to be investigated. Therefore, the aim of this study is to investigate whether there are any suppressive effects of plumbagin on the invasion and migration of human breast cancer MDA-MB-231SArfp cells and to explore potential functional mechanisms. We thus established an animal model of breast cancer bone metastases via injection of breast cancer cells intracardially. A non-invasive small animal monitoring system in addition to X-ray imaging and histologica...

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Section: Discussionmentioning

confidence: 99%

Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions

Yan

Liu

et al. 2013

Bone Res.

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“…A population bias was apparent in other reports as the cohorts showed relatively high proportion of hormonal receptor negative cases (>30%hour negative) 15 16. Poor OS for CD147-positive TNBC has been demonstrated 14. However, no similar trend could be observed by others in BLBC 20.…”

Section: Discussionmentioning

confidence: 74%

CD147 expression is associated with poor overall survival in chemotherapy treated triple-negative breast cancer

et al. 2018

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“…Triple-negative breast cancer (TNBC) is a molecular subtype of breast cancer characterized by the lack of immunohistochemical staining for estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression or amplification of human epidermal growth factor receptor 2 (HER2) [2–4]. Due to high rates of visceral and central nervous system metastases, patients with TNBC have a poorer disease specific survival than hormone receptor-positive subtypes [5–7].…”

Section: Introductionmentioning

confidence: 99%

TMPRSS4 as a Poor Prognostic Factor for Triple-Negative Breast Cancer

Cheng

Kong

2013

IJMS

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Triple-negative breast cancer (TNBC) is characterized by the lack of immunohistochemical staining for estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression or amplification of human epidermal growth factor receptor 2 (HER2). Our aim was to investigate the expression of transmembrane protease, serine 4 (TMPRSS4) in TNBC patients and its possible relationship to the outcome of the disease. A total of 72 TNBC patients and 109 non-TNBC patients who were diagnosed between 2003 and 2008 were enrolled in this study. Immunohistochemistry was used to compare the expression pattern of TMPRSS4 in TNBC and non-TNBC groups, and the prognostic significance was assessed by Kaplan-Meier analysis and Cox proportional hazards regression in TNBC patients. The rate of high expression of TMPRSS4 was significantly higher in TNBC group than that in non-TNBC group. High expression of TMPRSS4 was significantly correlated with lymph node metastasis, histological grade, and tumor size. TNBC patients with high TMPRSS4 expression showed the poorer overall survival (OS) and disease-free survival (DFS) than those patients with low TMPRSS4 expression. In multivariate analysis, only lymph node metastasis and TMPRSS4 expression were the independent prognostic factors for OS and DFS in TNBC. Our study provides evidence that TMPRSS4 expression is associated with lymph node metastasis, tumor size, and histological grade in TNBC patients, and also is an independent prognostic factor for TNBC.

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High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients

Cited by 77 publications

References 29 publications

Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions

Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions

CD147 expression is associated with poor overall survival in chemotherapy treated triple-negative breast cancer

TMPRSS4 as a Poor Prognostic Factor for Triple-Negative Breast Cancer

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