High Expression of Gastrin Receptor Protein in Injured Mucosa of Helicobacter pylori-Positive Gastritis

Takamura, Akemi; Ito, Masanori; Boda, Tomoyuki; Matsumoto, Yōko; Tanaka, Shinji; Yoshihara, Masaharu; Chayama, Kazuaki

doi:10.1007/s10620-012-2427-6

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…Studies have suggested that H pylori infection stimulates gastrin secretion, leading to an increase in the serum G‐17 level 25,26 . In our study, the serum G‐17 level in H pylori‐ positive group was higher than in the H pylori‐ negative group.…”

Section: Discussionsupporting

confidence: 39%

“…Studies have suggested that H pylori infection stimulates gastrin secretion, leading to an increase in the serum G-17 level. 25,26 In our study, the serum G-17 level in H pylori-positive group was higher than in the H pylori-negative group. Further, the serum G-17 level in type 1 H pylori-positive group was also higher than in the type 2 H pylori-positive group.…”

Section: Discussionsupporting

confidence: 39%

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Analysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population

Liu

Sun

Yuan

2020

Clinical Laboratory Analysis

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Helicobacter pylori (H pylori) is a gram-negative, spiral-shaped bacterium that is known to have infected more than half of the world's population and is the only pathogenic bacteria currently known to survive in the human stomach. Helicobacter pylori is listed as grade 1 carcinogen in the list of carcinogens published by the World Health Organization. It changes the structure and function of the gastric mucosa following infection, eventually leading to a variety of gastric diseases. 1-3 Gastrin-17 (G-17) is an important gastrointestinal hormone which is mainly secreted by the gastrointestinal G cells. It stimulates the secretion of gastric acid and pepsinogen, promotes proliferation of the gastric mucosal cells, enhances the motility of the gastrointestinal tract, and promotes the secretion of pancreatic juice and bile.

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Section: Discussionsupporting

confidence: 39%

Section: Discussionsupporting

confidence: 39%

Analysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population

Liu

Sun

Yuan

2020

Clinical Laboratory Analysis

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“…Ito et al demonstrated that the polyclonal antibody OK-524 recognizes human GR and confirmed the expression of GR in parietal cells, enterochromaffin-like cells, and foveolar epithelium with intestinal metaplasia ( 18 ). Takamura et al demonstrated a significantly high expression of GR in the foveolar epithelium of the regenerating injured mucosa infected with H. pylori ( 23 ). Although this patient had no history of H. pylori infection, immunohistochemical staining of GHP using OK-524 revealed an expression of GR in the focal foveolar epithelium of GHP ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of <i>Helicobacter pylori</i> Infection

et al. 2017

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A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation. Thus, the administration of proton pump inhibitors may be a risk factor for the development of GHP independent of H. pylori infection.

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“…Gastrin itself is important for homeostasis in the intact gastric mucosa, and it has a complex role in gastric carcinogenesis, including the mediation of proliferation, angiogenesis and tissue invasion [193]. The gastrin receptor expression is increased in H. pylori gastritis [194] partly due to an IL1β-induced downregulation of gastrin and histamine levels in the stomach to inhibit acid secretion from parietal cells [115,195,196]. …”

Section: Response To H Pylori In the Gastric Mucosamentioning

confidence: 99%

Helicobacter pylori and Gastric Cancer

Bornschein

Malfertheiner

2014

Dig Dis

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Infection with Helicobacter pylori is established as the major risk factor for gastric cancer development. Damage of the mucosal barrier due to H. pylori-induced inflammation enhances the carcinogenic effect of other risk factors such as salt intake or tobacco smoking. The genetic disposition of both the bacterial strain and the host can increase the potential towards gastric cancer formation. Genetic variance of the bacterial proteins CagA and VacA is associated with a higher gastric cancer risk, as are polymorphisms and epigenetic changes in host gene coding for interleukins (IL1β, IL8), transcription factors (CDX2, RUNX3) and DNA repair enzymes. Application of high-throughput assays for genome-wide assessment of either genetic structural variance or gene expression patterns may lead to a better understanding of the pathobiological background of these processes, including the underlying signaling pathways. Understanding of the stepwise alterations that take place in the transition from chronic atrophic gastritis, via metaplastic changes, to invasive neoplasia is vital to define the ‘point of no return' before which eradication of H. pylori has the potential to prevent gastric cancer. Currently, eradication as preventive strategy is only recommended for high-incidence regions in Asia; large population studies with an adequate follow-up are required to demonstrate the effectiveness of such an approach in Western populations.

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High Expression of Gastrin Receptor Protein in Injured Mucosa of Helicobacter pylori-Positive Gastritis

Abstract: Gastric mucosal injury with H. pylori infection destroys the pH barrier on the foveolar epithelium and may induce GR expression through pH changes.

Cited by 11 publications

References 29 publications

Analysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population

Analysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population

Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of <i>Helicobacter pylori</i> Infection

Helicobacter pylori and Gastric Cancer

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