High expression of MARVELD3 as a potential prognostic biomarker for oral squamous cell carcinoma

Huang, Ke; Meng, Yucheng; Lu, Jiyuan; Xu, Lingdan; Wang, Shiqi; Xu, Zhaoqing

doi:10.3389/fgene.2022.1050402

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Additionally, in HPV positive tumor cells, E6-mediated inhibition of MAGI-1 function contributes to HPVinduced malignancy by perturbing tight junction assembly with concomitant stimulation of proliferation and inhibition of apoptosis [43,44]. High expression of MARVELD3 as a potential prognostic biomarker for oral squamous cell carcinoma [45]. Also, HPV infection results in reduced expression of genes for tight junctions with potential impact on HIV infection [46].…”

Section: Igf2bp3 Was Related To the Tight Junctions In Hpv-related Cescmentioning

confidence: 99%

IGF2BP3 is associated with HPV status and tight junction in HPV-related cervical cancer

Han

Han#

et al. 2023

Preprint

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Background Although m6A modification was known to have broad effects on malignant tumors by participating in tumor proliferation, differentiation, tumorigenesis, invasion and metastasis, as oncogenes or anti-oncogenes, their effects of microbes in cancers have been rarely disputed. To investigate the function of IGF2BP3, one of the indispensable regulators of m6A, in HPV virus invading and transmitting, integrative analyses was performed in this study and identified that it was highly expressed in tumors and was related to the poor prognosis in CESC. Methods We investigate the expresseion level of IGF2BP3 and its prognostic value in CESC via multiple datasets including TCGA, GTEx datasets and TIMER. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of differentially expressed genes were performed using GOplot, org.Hs.eg.db and clusterProfiler packages and visualized using the ggplot2 package Results In HPV-positive tumors, IGF2BP3 was positively associated with tumor HPV status. Further analysis demonstrated that IGF2BP3 high status was correlated with signaling pathways related to cell-cell and cell-ECM interactions, including receptor ligand activity, neuroactive ligand receptor interaction and chemical carcinogenesis receptor activation. Moreover, correlation analysis showed that IGF2BP3 would impair the formation of cell polarity and cell-cell contacts by dysregulating the expression of tight junction molecules. Conclusions Our results identified that IGF2BP3 high status, is associated with poor prognosis and HPV status, and IGF2BP3 serves as a mediator of the tight junction formation in HPV-associated cancer, which provides a promising therapeutic target for anti-cancer schedule.

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Section: Igf2bp3 Was Related To the Tight Junctions In Hpv-related Cescmentioning

confidence: 99%

IGF2BP3 is associated with HPV status and tight junction in HPV-related cervical cancer

Han

Han#

et al. 2023

Preprint

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Artificial miRNAs derived from miR‐181 family members have potential in cancer therapy due to an altered spectrum of target mRNAs

et al. 2023

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miRNAs are a class of noncoding RNAs with gene regulation properties, and they function as key factors in cell homeostasis. The interaction of miRNAs with their target mRNAs is largely considered to rely on sequence complementarity; however, some evidence indicates that mature miRNAs can adopt diverse conformations with implications for their function. Using the oncogenic miR‐181 family as a study model, we suggest that a potential relationship between the primary sequence and secondary structure of miRNAs may have an impact on the number and spectrum of targeted cellular transcripts. We further emphasize that specific alterations in miR‐181 primary sequences might impose certain constraints on target gene selection compared with the wild‐type sequences, leading to the targeting of new transcripts with upregulated function in cancer.

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High expression of MARVELD3 as a potential prognostic biomarker for oral squamous cell carcinoma

Cited by 2 publications

References 27 publications

IGF2BP3 is associated with HPV status and tight junction in HPV-related cervical cancer

IGF2BP3 is associated with HPV status and tight junction in HPV-related cervical cancer

Artificial miRNAs derived from miR‐181 family members have potential in cancer therapy due to an altered spectrum of target mRNAs

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