High expression of metadherin correlates with malignant pathological features and poor prognostic significance in papillary thyroid carcinoma

Li, Wenfang; Wang, Gen; Zhao, Zhenze; Liu, Changan

doi:10.1111/cen.12683

Cited by 10 publications

(18 citation statements)

References 43 publications

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“…We utilized several bioinformatic target prediction algorithms (TargetScan, PicTar, miRanda) to search for the targets related to tumour cell growth. Among predicted target genes, MTDH was revealed to be involved in tumourigenesis such as in breast cancer, thyroid tumours and prostate cancer . Accordingly, we evaluated the expression levels of MTDH in the tissue samples used for miRNA validation experiments.…”

Section: Resultsmentioning

confidence: 99%

“…MTDH , initially identified as a neuropathology‐associated gene in primary human foetal astrocytes, has been established in recent years as a potentially oncogene in multiple types of cancers . Meanwhile, multiple lines of evidence have suggested miR‐375 exerting its tumour‐suppressive effect by repressing several critical oncogenes including directly targeting MTDH in hepatocellular carcinoma .…”

Section: Discussionmentioning

confidence: 99%

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Downregulation of miR‐375 in aldosterone‐producing adenomas promotes tumour cell growth via MTDH

Cao

et al. 2015

Clinical Endocrinology

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Downregulation of miR‐375 in aldosterone‐producing adenomas promotes tumour cell growth via MTDH

Cao

et al. 2015

Clinical Endocrinology

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“…It was first discovered in human fetal astrocytes in 2002 and is also termed astrocyte elevated gene-1 (28). MTDH is upregulated in multiple types of human cancer, including breast cancer (29), gastric cancer (30), thyroid carcinoma (31), and cervical cancer (32). MTDH contributes to the regulation of cancer oncogenesis and progression and regulates cell proliferation, cell cycle, apoptosis, metastasis, epithelial-to-mesenchymal transition and angiogenesis (33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑758 inhibits tumorous behavior in tongue squamous cell carcinoma by directly targeting metadherin

Zhang

Zhao

2019

Mol Med Report

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Numerous microRNAs (miRNAs) are dysregulated in tongue squamous cell carcinoma (TSCC), and their dysregulation has been demonstrated to have a strong correlation with TSCC progression via regulation of their targets. Therefore, miRNAs have potential use in the diagnosis and treatment of patients with TSCC. In the present study, miRNA-758 (miR-758) expression in TSCC tissues and cell lines was detected through reverse transcription-quantitative polymerase chain reaction, and the effects of miR-758 on TSCC cell proliferation and invasion were investigated by using Cell Counting kit-8 and Transwell invasion assays. A luciferase reporter assay was performed to determine the target interaction between miR-758 and metadherin (MTDH) in TSCC cells. The results revealed that miR-758 was downregulated in TSCC tissues and cell lines. miR-758 overexpression restricted the proliferation and invasion of TSCC cells. Additionally, MTDH was verified as a direct target gene of miR-758 in TSCC cells. Furthermore, MTDH was observed to be upregulated in TSCC tissues, and the upregulation of MTDH was inversely correlated with miR-758 expression. Moreover, restored MTDH expression significantly counteracted the suppressive effects of miR-758 overexpression on TSCC cells. These results suggested that miR-758 may prevent TSCC progression and development by directly targeting MTDH, thereby providing evidence that miR-758 is a novel therapeutic target for the treatment of patients with TSCC.

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“…In the current study, we demonstrated for the first time that MTDH is a direct and functional target of miR-874 in RB cells. MTDH, also known as astrocyte-elevated gene-1, is located on chromosome 8q22 and is overexpressed in a variety of human malignant tumours, such as thyroid (32), breast (33), gastric (34), colorectal (35), and cervical (36) cancers. MTDH expression is also upregulated in RB tissues and cell lines and is linked with the tumor stage of RB patients (22).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

2018

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MicroRNAs (miRNAs/miRs) serve important roles in regulating gene expression by directly binding to the 3'‑untranslated regions of target genes. Multiple miRNAs are dysregulated in retinoblastoma (RB) and their dysregulation is closely related to RB malignancy. Therefore, exploring the detailed roles of miRNAs in RB is valuable to facilitate the development of effective therapeutic targets for patients with this disease. miRNA‑874‑3p (miR‑874) has been recently reported to be downregulated in several types of human cancer and serves an essential role in cancer progression. However, the expression pattern and detailed roles of miR‑874 in RB, as well as the underlying molecular mechanisms in RB, have not been clearly elucidated. Therefore, this study detected miR‑874 expression in RB tissues and cell lines. The biological roles of miR‑874 in RB were determined and the underlying mechanisms of its actions in RB cells were also examined. This study revealed that miR‑874 expression was aberrantly underexpressed in RB tissues and cell lines. However, returning miR‑874 expression restricted the proliferative and invasive abilities of RB cells. In terms of the underlying mechanism, metadherin (MTDH) was validated as a direct target gene of miR‑874 in RB cells. MTDH inhibition could imitate the inhibitory roles of miR‑874 overexpression in RB cells. Furthermore, forced MTDH expression partially reversed the suppressive effects of miR‑874 on RB cells. In conclusion, this study revealed that miR‑874 may inhibit RB progression by directly targeting MTDH. Restoration of miR‑874 expression may be a novel strategy for preventing the rapid growth and metastasis of RB cells.

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High expression of metadherin correlates with malignant pathological features and poor prognostic significance in papillary thyroid carcinoma

Abstract: High MTDH expression in PTC might play an important role in tumour growth and metastasis, and targeting MTDH treatment might have potential therapeutic value for patients with PTC.

Cited by 10 publications

References 43 publications

Downregulation of miR‐375 in aldosterone‐producing adenomas promotes tumour cell growth via MTDH

Downregulation of miR‐375 in aldosterone‐producing adenomas promotes tumour cell growth via MTDH

MicroRNA‑758 inhibits tumorous behavior in tongue squamous cell carcinoma by directly targeting metadherin

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

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