High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis

Chien, Chih‐Yen; Su, Chih‐Ying; Hwang, Chung‐Feng; Chuang, Hui‐Ching; Chen, Ching-Mei; Huang, Chao‐Cheng

doi:10.1002/jso.20546

Cited by 54 publications

(53 citation statements)

References 34 publications

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“…The expression of CD105 observed by different researchers in OSCC was significantly higher i.e., to the extent of 75% of cases [25,[27][28]. Expression of CD 105, in OSCC patients habituated to tobacco, in this present study was observed in 13 of 20 cases (65%) [Table/ Fig-7].…”

Section: Discussionsupporting

confidence: 52%

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Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Basnaker¹,

Bnvs²

2014

JCDR

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Objective: To assess the expression of Endoglin and Microvessel Density in clinically normal oral mucosa of non-tobacco and tobacco habituated patients & also histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) patients. Materials and Methods:Twenty cases of clinically normal oral mucosa with tobacco habituation in the form of chewing or smoking, 20 histopathologically confirmed cases of OSCC and twelve normal healthy oral mucosal cases without tobacco habituation in any form, served as control group, were immunohistochemically analysed for expression of Endoglin (CD-105). Chi-square test is used to determine statistical analysis and significance. Result & Conclusion:The finding of 65% of Endoglin CD -105 positivity and microvessel density (MVD) in the mucosal specimens of tobacco users may be attributed as neoangiogenesis or angiogenic squamous dysplasia like phenomenon occurring as important pathological biomarker preceding oral cancer development, and may therefore be useful as a predictive marker of malignancy.

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Section: Discussionsupporting

confidence: 52%

“…Endoglin CD 105 expression in OSCC was also studied by these researchers and are considered to be significant [24,25,26,27].…”

Section: Discussionmentioning

confidence: 99%

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Basnaker¹,

Bnvs²

2014

JCDR

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“…One of the first papers about the correlation between VEGF and angiogenesis was published by Artese et al in 2001, but no correlation was found between intensity of VEGF positivity and histological grading or lymph node status in OSCC [51]. Some studies depicted that VEGF-positive carcinoma had significantly poorer survival [52,53]. Other articles demonstrated a correlation between VEGF expression and survival.…”

Section: Vegf In Osccmentioning

confidence: 99%

Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients

Eckert

Kappler

Schubert

et al. 2012

Oral Maxillofac Surg

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“…Previous studies indicate that strong expression of CD105 in tumor-related, newly generated vascular endothelium is a more accurate index for judging endothelial reproductive state, and it is closely related to tumor generation and metastasis [24][25][26][27] . Contrasting with endothelial cell markers such as CD31, CD34 and Ⅷ factor-related antigens, the difference is that CD105 as a marker of angiogenesis is only strongly expressed in vascular endothelial cells of tumor tissues at the reproduction stage (i.e.…”

Section: Discussionmentioning

confidence: 99%

Correlation of matrix metalloproteinase suppressor genes RECK, VEGF, and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma

Li¹,

Gao²,

Zhao³

et al. 2007

WJG

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AIM:To explore the expression of reversion inducing cysteine-rich protein with Kazal motifs (RECK), vascular endothelial growth factor (VEGF) and endoglin (CD105) protein and its correlation with occurrence, development, invasion and metastasis in esophageal squamous cell carcinoma (ESCC). METHODS:Streptavidin-peroxidase (SP) immunohistochemistry was used to detect expression of RECK and VEGF in 62 cases of ESCC, 31 cases of adjacent atypical hyperplastic epithelium and 62 cases of normal esophageal epithelium. CD105 Mb was used to assess microvessel density (MVD). RESULTS:T h e e x p r e s s i o n o f R E C K w a s c l o s e l y correlated with histological grade, infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK decreased during cancer development: normal esophageal epithelium (85.5%, 53/62), adjacent atypical hyperplastic epithelium (71.0%, 22/31), and carcinoma (59.7%, 37/62). There was a significant difference among the groups (P < 0.05). The expression of VEGF protein was closely correlated with infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of VEGF protein increased during cancer development: normal esophageal epithelium (29.0%, 18/62), adjacent atypical hyperplastic epithelium (54.8%, 17/31), and carcinoma (67.7%, 42/62). There was a significant difference among the groups (P < 0.05). MVDCD105 increased in accordance with histological grade, but there was no significant difference (grade Ⅰ, 36.92 ± 10.85; grade Ⅱ, 37.65 ± 9.50; and grade Ⅲ, 38.06 ± 12.19). The MVDCD105 was closely correlated with infiltration and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK was inversely correlated with the expression of VEGF and CD105.

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High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis

Abstract: Besides the image studies, the expressions of both CD105 and VEGF could be useful to guide the elective treatment for clinical N0 neck in early oral cancer.

Cited by 54 publications

References 34 publications

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients

Correlation of matrix metalloproteinase suppressor genes RECK, VEGF, and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma

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