High frequency of contact allergy to gold in patients with endovascular coronary stents

Ekqvist, Susanne; Svedman, Cecilia; Möller, Halvor; Kehler, M.; Pripp, Carl-Magnus; Björk, Jonas; Gruvberger, Birgitta; Holmström, Eva B; Gustavsson, Carl Gunnar; Bruze, M.

doi:10.1111/j.1365-2133.2007.08119.x

Cited by 49 publications

(34 citation statements)

References 35 publications

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“…316,320À322 Similarly, gold dental implants are associated with detectable serum gold concentrations and an increased incidence of contact allergy to gold. 321,322 Interestingly, the release of gold into the blood from dental restorations is enhanced by cigarette smoking. 323 In a randomized trial of gold-coated versus stainless steel stents, no difference in outcomes was noted at 30 days, but at a year those who received gold-coated stents had higher rates of restenosis and repeat revascularization, as well as lower rates of event-free survival.…”

Section: Goldmentioning

confidence: 99%

Environmental Toxins and the Heart

2015

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Section: Goldmentioning

confidence: 99%

Environmental Toxins and the Heart

2015

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“…88,89 There is also a correlation between gold allergy and the presence of goldplated stents for coronary arteries, as well as for the risk of restenosis. [90][91][92] The importance of patch testing with gold has been addressed in a review by Möller. 88 Other substances that can cause systemic contact dermatitis…”

Section: Mercurymentioning

confidence: 99%

Systemic contact dermatitis

Veien¹

2011

Int J Dermatology

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Systemic contact dermatitis is an inflammatory skin disease that may occur in persons with contact allergy when they are exposed to the hapten orally, transcutaneously, per rectum, intravesically, intravenously, or by inhalation. The most common causes of systemic contact dermatitis are drugs used both topically and systemically. Other causes are ubiquitously occurring haptens, such as the metals nickel, cobalt, gold, and chromate, and aromatic substances such as spices. Avoidance of the offending hapten is the most obvious treatment. For some haptens, such as nickel, diet treatment may be effective. Chelation therapy with disulfiram is another therapeutic option in nickel-allergic patients with systemic contact dermatitis. Hyposensitization therapy has been attempted with some success in systemic contact dermatitis caused by nickel and Parthenium hysterophorus.

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“…This provides the background for a ‘systemic allergic dermatitis' (see below), occurring after topical exposure to an allergen and resulting in a distant skin reaction (1,22). Furthermore, contact allergy to gold is correlated to the presence of dental gold (23–27), but there are only a few distant skin reactions reported supposedly caused by dental gold (25–28).…”

Section: Test Techniquementioning

confidence: 99%

Contact allergy to gold as a model for clinical‐experimental research

Möller

2010

Contact Dermatitis

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The high frequency of contact allergy to gold in patients with dermatitis was established after exhaustive skin testing, determining the right test agent, the best concentration, and repeated test readings. Metallic gold in contact with skin is slowly ionized, permitting absorption and haptenisation. Contact allergy to gold is statistically correlated to the presence of dental gold. But in many case reports it has also been attributed to wearing gold jewellery, albeit not statistically demonstrated. Epicutaneous testing with gold salts increases the blood gold level, and by intramuscular injection systemic contact dermatitis is provoked in an allergic individual. In coronary heart disease, gold-coated intravascular stents have been shown to be correlated to contact allergy and even to an increased risk of restenosis. Gold is far from inert.

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High frequency of contact allergy to gold in patients with endovascular coronary stents

Cited by 49 publications

References 35 publications

Environmental Toxins and the Heart

Environmental Toxins and the Heart

Systemic contact dermatitis

Contact allergy to gold as a model for clinical‐experimental research

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