High frequency of parvovirus B19 DNA in bone marrow samples from rheumatic patients

Lundqvist, Anders; Isa, Adiba; Tolfvenstam, Thomas; Kvist, G; Broliden, Kristina

doi:10.1016/j.jcv.2004.11.011

Cited by 23 publications

(15 citation statements)

References 15 publications

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“…The majority of acute infections remain asymptomatic or cause mild, nonspecific, cold-like symptoms. However, in single cases, severe clinical conditions, such as a variety of cardiac diseases, acute arthopathia and juvenile idiopathic arthritis [12][13][14][15], have been linked to the virus [11]. The infection shows life-threatening courses in immunocompromised patients.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

2010

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Section: Discussionmentioning

confidence: 99%

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

2010

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“…B19 IgG and IgM were detected using enzyme immune assay (EIA; Biotrin International Ltd, Dublin, Ireland) according to the manufacturer's instructions. Presence of B19 DNA in serum and BM was confirmed using a nested PCR with a sensitivity of 10 3 geq/ml [10] and a quantitative PCR with a sensitivity of 10 2 geq/ml [2].…”

Section: Methodsmentioning

confidence: 99%

Cytokine responses in acute and persistent human parvovirus B19 infection

Isa

Lundqvist

Lindblom

et al. 2006

Clinical and Experimental Immunology

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“…Cases have been reported of RA development after acute Parvo B19 infection and of persistence of B19 RNA and of the VP-1 antigen in the synovial tissue of RA patients [7]. In a study on bone marrow samples from RA patients, 26% were positive for parvovirus B19, as compared to 4% in an historical control group of bone marrow [8]. Regarding bacterial infections, RA has been consistently associated with high titers of antibodies against Proteus mirabilis [9].…”

Section: Clinical Associations With Infectionsmentioning

confidence: 99%

Infections and Autoimmunity: A Panorama

Pordeus

Szyper‐Kravitz

Levy

et al. 2008

Clinic Rev Allerg Immunol

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For more than 2,000 years, it was thought that malignant spirits caused diseases. By the end of nineteenth century, these beliefs were displaced by more modern concepts of disease, namely, the formulation of the "germ theory," which asserted that bacteria or other microorganisms caused disease. With the emergence of chronic degenerative and of autoimmune diseases in the last century, the causative role of microorganisms has been intensely debated; however, no clear explanatory models have been achieved. In this review, we examine the current available literature regarding the relationships between infections and 16 autoimmune diseases. We critically analyzed clinical, serological, and molecular associations, and reviewed experimental models of induction of and, alternatively, protection from autoimmune diseases by infection. After reviewing several studies and reports, a clinical and experimental pattern emerges: Chronic and multiple infections with viruses, such as Epstein-Barr virus and cytomegalovirus, and bacteria, such as H. pylori, may, in susceptible individuals, play a role in the evolvement of autoimmune diseases. As the vast majority of infections pertain to our resident microbiota and endogenous retroviruses and healthy carriage of infections is the rule, we propose to focus on understanding the mechanisms of this healthy carrier state and what changes its configurations to infectious syndromes, to the restoration of health, or to the sustaining of illness into a chronic state and/or autoimmune disease. It seems that in the development of this healthy carriage state, the infection or colonization in early stages of ontogenesis with key microorganisms, also called 'old friends' (lactobacilli, bifidobacteria among others), are important for the healthy living and for the protection from infectious and autoimmune syndromes.

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High frequency of parvovirus B19 DNA in bone marrow samples from rheumatic patients

Cited by 23 publications

References 15 publications

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

Cytokine responses in acute and persistent human parvovirus B19 infection

Infections and Autoimmunity: A Panorama

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