ABSTRACT:In newborn infants, closed endotracheal tube (ETT) suction may reduce associated adverse effects, but it is not clear whether ventilation is maintained during the procedure. We aimed to determine the effect of ETT size, catheter size, and suction pressure on ventilation parameters measured distal to the ETT. Suction was performed on a test lung, ventilated with conventional (CMV) and high-frequency oscillatory ventilation (HFOV) using ETT sizes 2.5-4.0 mm, catheter sizes 5-8 French gauge (Fr), and suction pressures 80 -200 mm Hg. Tracheal and circuit peak inspiratory pressure, positive end-expiratory pressure, and tracheal tidal volume (V T ) were recorded for each suction episode. During both CMV and HFOV, tracheal pressures and V T were considerably reduced by suctioning; this reduction was dependent on the combination of ETT, catheter, and suction pressure. Loss of V T , inflation pressure (CMV), and pressure amplitude (HFOV) occurred primarily with insertion of the catheter, and loss of end-expiratory pressure (CMV) and mean tracheal pressure (HFOV) occurred with the application of suction. Circuit pressures were reduced to lesser degree. We conclude that airway pressures and V T are not maintained during closed endotracheal suction with either CMV or HFOV, and choice of equipment and settings will affect the degree of interruption to ventilation. (Pediatr Res 66: 400-404, 2009) E ndotracheal tube (ETT) suction is performed periodically on infants receiving mechanical ventilation to clear secretions from the ETT and airway. Although necessary, it is associated with adverse effects including atelectasis, hypoxemia, and cardiovascular instability, partly attributable to loss of airway pressure and interruption of ventilation (1-5). Closed suction, performed without disconnection from respiratory support, has been shown to reduce adverse effects (6 -8), but whether ventilation is maintained during closed suction has not been demonstrated in a neonatal population.With adult-sized ETTs, airway pressure has been shown to decrease during closed suction and concerns have been raised about the potential for very large negative airway pressures during the procedure (4,9,10). However only one study has quantified pressure and tidal volume (V T ) changes during closed suction with neonatal equipment (11). Using an in vitro model, a considerable reduction in airway pressures and V T was demonstrated, particularly when a large catheter relative to the ETT was used. However, the authors did not report results using 5 or 7 French gauge (Fr) suction catheters, nor did they measure the effect of varying the suction pressure.Airway pressures during closed suction are influenced by ventilation mode in adult models (4,10), but this effect has not been studied using neonatal ventilators. Of particular interest is the performance of closed suction catheters during highfrequency oscillatory ventilation (HFOV), because closed suction is generally recommended for patients receiving this ventilation mode (12,13).This study ai...