High grade angiosarcoma arising in fibroadenoma

Abstract

Primary angiosarcoma of the breast is a rare tumour that account for fewer than 0.05% of all malignant mammary tumours. Angiosarcoma may have an perfidious clinical onset. Radiologic findings are often nonspecific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastases. Aggressive surgical resection is the mainstay of treatment. The role of adjuvant therapy has not yet been well established.Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date.

Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma

“…Human AS and canine HSA are lethal neoplasms characterized by the aggressive growth of malignant endothelial cells, widespread metastases and poor response to chemotherapy (Johnson et al, 2007;Babarovi c et al, 2011). Human AS can arise anywhere in the body, but presents most commonly as a cutaneous disease (Mark et al, 1996).…”

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

“…Exceptionally, sarcomas may also develop within fibroadenomas (e.g. angiosarcoma, osteosarcoma) [33,34]. Little is known about the molecular mechanisms that drive the development and prog ression of malignant tumors within fibroadenomas.…”

Breast Cancer Arising from a Suspected Fibroadenoma during Pregnancy: A Case Report and Review of Literature

“…However, when such transformation occurs, carcinomas in situ is the most commonly found lesion with the incidence of 70% to 95%; invasive carcinoma which occurs less frequently is reported to be present in 5% to 30% of cases [4,5,16,17]. Although extremely rare, sarcomas such as angiosarcoma, osteosarcoma have also been reported to arise within fibroadenomas [18,19]. There is not much data about the malignant transformation of fibroadenoma during pregnancy, researchers have not been able to propose the exact molecular mechanism which initiates and propagates the progression of malignancy within fibroadenoma, but the rapid growth of fibroadenoma under the effect of pregnancy hormones may play an important role [20,21].…”