High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 2: Spectroscopy, Chemical Exchange Saturation, Multiparametric Imaging, and Radiomics

Booth, Thomas C.; Wiegers, Evita C; Warnert, Esther; Schmainda, Kathleen M.; Riemer, Frank; Nechifor, Ruben Emanuel; Keil, Vera C.; Hangel, Gilbert; Figueiredo, Patrícia; Álvarez‐Torres, María del Mar; Henriksen, Otto Mølby

doi:10.3389/fonc.2021.811425

Cited by 27 publications

(26 citation statements)

References 146 publications

(153 reference statements)

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“…Pediatric high-grade glioma (pHGG) is one of the rapidly lethal malignancies at young age [ 150 , 151 ]. Among them, glioblastoma, also known as glioblastoma multiforme (GBM), is the most prevalent and aggressive [ 152 ]. To date, surgical resection followed by adjuvant radiation therapy and chemotherapy with oral temozolomide (TMZ) is the most common and effective treatment for GBM patients [ 153 ].…”

Section: Overview Of Pyroptosismentioning

confidence: 99%

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

Wang

Zhou

et al. 2022

J Hematol Oncol

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Pediatric cancers are the driving cause of death for children and adolescents. Due to safety requirements and considerations, treatment strategies and drugs for pediatric cancers have been so far scarcely studied. It is well known that tumor cells tend to progressively evade cell death pathways, which is known as apoptosis resistance, one of the hallmarks of cancer, dominating tumor drug resistance. Recently, treatments targeting nonapoptotic cell death have drawn great attention. Pyroptosis, a newly specialized form of cell death, acts as a critical physiological regulator in inflammatory reaction, cell development, tissue homeostasis and stress response. The action in different forms of pyroptosis is of great significance in the therapy of pediatric cancers. Pyroptosis could be induced and consequently modulate tumorigenesis, progression, and metastasis if treated with local or systemic therapies. However, excessive or uncontrolled cell death might lead to tissue damage, acute inflammation, or even cytokine release syndrome, which facilitates tumor progression or recurrence. Herein, we aimed to describe the molecular mechanisms of pyroptosis, to highlight and discuss the challenges and opportunities for activating pyroptosis pathways through various oncologic therapies in multiple pediatric neoplasms, including osteosarcoma, neuroblastoma, leukemia, lymphoma, and brain tumors.

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Section: Overview Of Pyroptosismentioning

confidence: 99%

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

Wang

Zhou

et al. 2022

J Hematol Oncol

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“…Novel imaging biomarkers in glioma patients may help diagnosis, prognosis, and treatment decisions by improving tumor characterization and delineation 1–3 . One such imaging biomarker is amide proton transfer (APT) imaging.…”

mentioning

confidence: 99%

Reproducibility of 3 T APT‐CEST in Healthy Volunteers and Patients With Brain Glioma

Wamelink

Kuijer

Padrela

et al. 2022

Magnetic Resonance Imaging

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Background Amide proton transfer (APT) imaging is a chemical exchange saturation transfer (CEST) technique offering potential clinical applications such as diagnosis, characterization, and treatment planning and monitoring in glioma patients. While APT‐CEST has demonstrated high potential, reproducibility remains underexplored. Purpose To investigate whether cerebral APT‐CEST with clinically feasible scan time is reproducible in healthy tissue and glioma for clinical use at 3 T. Study Type Prospective, longitudinal. Subjects Twenty‐one healthy volunteers (11 females; mean age ± SD: 39 ± 11 years) and 6 glioma patients (3 females; 50 ± 17 years: 4 glioblastomas, 1 oligodendroglioma, 1 radiologically suspected low‐grade glioma). Field Strength/Sequence 3 T, Turbo Spin Echo ‐ ampling perfection with application optimized contrasts using different flip angle evolution ‐ chemical exchange saturation transfer (TSE SPACE‐CEST). Assessment APT‐CEST measurement reproducibility was assessed within‐session (glioma patients, scan session 1; healthy volunteers scan sessions 1, 2, and 3), between‐sessions (healthy volunteers scan sessions 1 and 2), and between‐days (healthy volunteers, scan sessions 1 and 3). The mean APT CEST values and standard deviation of the within‐subject difference (SD diff ) were calculated in whole tumor enclosed by regions of interest (ROIs) in patients, and eight ROIs in healthy volunteers—whole‐brain, cortical gray matter, putamen, thalami, orbitofrontal gyri, occipital lobes, central brain—and compared. Statistical Tests Brown‐Forsythe tests and variance component analysis (VCA) were used to assess the reproducibility of ROIs for the three time intervals. Significance was set at P < 0.003 after Bonferroni correction. Results Intratumoral mean APT CEST was significantly higher than APT CEST in healthy‐appearing tissue in patients (0.5 ± 0.46%). The average within‐session, between‐sessions, and between‐days SD diff of healthy control brains was 0.2% and did not differ significantly with each other (0.76 > P > 0.22). The within‐session SD diff of whole‐brain was 0.2% in both healthy volunteers and patients, and 0.21% in the segmented tumor. VCA showed that within‐session factors were the most important (60%) for scanning variance. Data Conclusion Cerebral APT‐CEST imaging may show good scan–rescan reproducibility in healthy tissue and tumors with clinically feasible scan times at 3 T. Short‐term measurement effects may be the dominant components for reproducibility. Level of Evidence 2 Technical Efficacy ...

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“…On the other hand, the combination of functional MRI with AI techniques can be helpful in differentiating the effect on images caused by immunotherapy from natural tumor progression. A meta-analysis that studies treatment response monitoring biomarkers has recently been published, proposing advanced MRI techniques in the clinic and the latest bench-to-bedside developments 6,7 . Part 1 of this meta-analysis 6 includes the contribution of perfusion and diffusion techniques, and Part 2 7 focused on spectroscopy, chemical exchange saturation, multiparametric imaging, and radiomics.…”

Section: Major Challenges Of Implementing Immunotherapy and Potential...mentioning

confidence: 99%

“…A meta-analysis that studies treatment response monitoring biomarkers has recently been published, proposing advanced MRI techniques in the clinic and the latest bench-to-bedside developments 6,7 . Part 1 of this meta-analysis 6 includes the contribution of perfusion and diffusion techniques, and Part 2 7 focused on spectroscopy, chemical exchange saturation, multiparametric imaging, and radiomics. Some of these advanced MRI techniques show huge promise in treatment response assessment and may be proposed as helpful for evaluating radiographic responses to immunotherapy.…”

Section: Major Challenges Of Implementing Immunotherapy and Potential...mentioning

confidence: 99%

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Characterization of vascular heterogeneity of astrocytomas grade 4 for supporting patient prognosis estimation, and treatment response assessment

Torres¹

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Brain tumors are one of the most devastating diseases today because of the significant cognitive impairment suffered by patients, high mortality rates, and poor prognosis.Astrocytomas grade 4 bring five-year survival in approximately 5% of diagnosed patients, being the most aggressive and lethal tumors of the Central Nervous System (CNS).Astrocytomas grade 4 continue to be an unresolved complex medical problem. Despite accounting for more than 60% of malignant brain tumors in adults, these tumors have a low relative prevalence and are considered an orphan disease, making difficult developing new drugs or treatments that might benefit patients.The aggressiveness of these tumors is due to different characteristics, such as strong angiogenesis, necrosis, vascular microproliferation, the capacity of the tumor cells to invade and infiltrate, and a particular immune microenvironment. In addition, due to the rapid progression of astrocytomas grade 4, different specific regions coexist in the lesion area which change over time. This complex nature, along with the marked interpatient, intratumor, and longitudinal heterogeneity, makes complicate the success of a single efficient treatment for all patients. Magnetic Resonance Imaging (MRI) represents a useful technique to characterize tumormorphology and vascularity. Using advanced and robust methods to analyze MR images collected from initial stages of patient management allows the delineation of different regions of astrocytomas grade 4, becoming useful tools for researchers, radiologists and neurosurgeons. In addition, the calculation of imaging vascular biomarkers, such as those proposed in this thesis, would facilitate tumor characterization, prognosis estimation and more personalized treatment approaches. This thesis proposes four fundamental pillars to advance the management of astrocytomas grade 4. These include I) the multilevel characterization of the tumor to improve classifications of high-grade CNS gliomas; II) the search and development of robust biomarkers for estimating patient prognosis from the presurgical moment; III) as well as for evaluating the response to treatments and the selection of patients who may benefit from specific therapies; and IV) the design and implementation of clinical studies and protocols for long-term collecting data from internationally remarkable cohorts of patients.

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High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 2: Spectroscopy, Chemical Exchange Saturation, Multiparametric Imaging, and Radiomics

Cited by 27 publications

References 146 publications

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

Reproducibility of 3 T APT‐CEST in Healthy Volunteers and Patients With Brain Glioma

Characterization of vascular heterogeneity of astrocytomas grade 4 for supporting patient prognosis estimation, and treatment response assessment

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