High incidence of obstetric complications in Kassala Hospital, Eastern Sudan

Ali, AbdelAziem A.; Okud, Amira; Khojali, Awadia; Adam, Ishag

doi:10.3109/01443615.2011.637140

Cited by 43 publications

(38 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-eclamsia is a multisystem disorder that complicates 3% -8% of pregnancies in western countries and constitutes a major source of morbidity and mortality worldwide [19] [20]. While in Sudan the complication with pre-eclampsia/eclampsia is 4.2% [21]. The current study aimed to estimate and evaluation of the plasma D-dimer level in Sudanese preeclampsia women.…”

Section: Discussionmentioning

confidence: 99%

Estimation of Plasma D-Dimer Levels in Sudanese Women with Preeclampsia

Abdelgadir¹,

Gaufri²

2017

OALib

View full text Add to dashboard Cite

Background: The literature suggests that the haemostatic abnormalities have taken a big part in preeclampsia. D-dimer is a biomarker of fibrin formation and degradation. Objective: The present study was aimed to estimate and evaluation of the plasma D-dimer levels in Sudanese preeclampsia women. Material and Methods: This is an analytical descriptive case control study done during March 2016. A total of 100 participants were enrolled in this study, classified into two groups: the first group consisted of 50 Sudanese women diagnosed by preeclampsia as patients group, while the second group consisted of 50 normotensive women and their age matched to patients, designated as normal control group. 3 milliter of veins blood samples were collected in containers containing 3.2% tri sodium citrate as anticoagulant, then the platelet-poor plasma was prepared immediately by centrifuging for 15 minutes at approx 3000 rpm. The plasma D-dimer levels were done using MISPA-i2 (Switzerland). The data were analyzed by using SPSS (version 20). Results: The current study showed that the D-dimer level was statistically significant higher in preeclampsia women compared with normotensive pregnant women (Mean ± SD: 1.016 ± 0.158 vs 0.168 ± 0.045 with P value 0.000, respectively). Conclusion: This study concluded that the plasma D-dimer level was significantly elevated in Sudanese women with preeclampsia. Subject AreasHematology

show abstract

Section: Discussionmentioning

confidence: 99%

Estimation of Plasma D-Dimer Levels in Sudanese Women with Preeclampsia

Abdelgadir¹,

Gaufri²

2017

OALib

View full text Add to dashboard Cite

show abstract

“…calcium and zinc supplement [18]. In Sudan, preeclampsia/eclampsia is a major cause of maternal and perinatal morbidity and mortality [1, 19, 20]. We have previously shown that preeclampsia is associated with oxidative stress [21].…”

Section: Introductionmentioning

confidence: 99%

Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia

et al. 2016

View full text Add to dashboard Cite

BackgroundAlthough the exact pathophysiology of preeclampsia is not fully understood, several elemental micronutrient abnormalities have been suggested to play a contributory role in preeclampsia.AimsTo investigate the levels of calcium, magnesium, zinc and copper in women with preeclampsia.Subjects and MethodsA case—control study was conducted in Omdurman Maternity Hospital, Sudan, during the period of September through December 2014. The cases were women with preeclampsia while healthy pregnant women were the controls. The medical and obstetrics history was gathered using questionnaires. The serum levels of calcium, magnesium, zinc and copper were measured using atomic absorption spectrophotometer.ResultsThere was no significant difference between the two groups in their age, gestational age, parity and body mass index. Zinc and copper levels were not significantly different between the two groups. In comparison with the controls, women with preeclampsia had a significantly lower median (inter-quartile) serum calcium [7.6 (4.0─9.6) vs. 8.1 (10.6─14.2), mg/dl, P = 0.032] and higher levels of magnesium [1.9 (1.4─2.5) vs. 1.4 (1.0─1.9) mg/dl; P = 0.003]. In binary logistic regression, lower calcium (OR = 0.73, 95% CI = 0.56 ─ 0.95, P = 0.021) and higher magnesium (OR = 5.724, 95% CI = 1.23 ─ 26.50, P = 0.026) levels were associated with preeclampsia. There were no significant correlations between levels of hemoglobin and these trace elements.ConclusionThe current study showed significant associations between preeclampsia and serum levels of calcium and magnesium.

show abstract

“…There is an extremely high maternal mortality in Sudan where preeclampsia/eclampsia is the main cause of obstetric complications and maternal deaths (17, 18). In Sudan, several aspects of preeclampsia were investigated (19–23); however, there were no published data on thyroid function/antibodies in preeclamptic patients.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

et al. 2015

View full text Add to dashboard Cite

Preeclampsia is an important cause of maternal and prenatal morbidity and mortality in the developing countries. Changes in thyroid function/antibodies profiles in preeclamptic women are controversial and were never investigated before in Sudan. A case–control study was conducted at Medani Hospital, Sudan, to investigate thyroid function/antibodies in preeclampsia. The sociodemographic, medical history was gathered using questionnaires. Thyroid hormones [thyroid-stimulating hormone (TSH), free tri-iodothyronine (T3), and free thyroxine (T4)] and anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies were measured using ELISA. The three groups [controls, mild, and severe preeclampsia (SP) (55 women in each arm)] were matched in age and parity. While median (interquartile range) of TSH was significantly lower, both free T3 and free T4 levels were significantly higher in women with preeclampsia than in the healthy controls. There was no significant difference in the TSH levels in women with MP and SP. In comparison with women with MP, women with SP had significantly higher levels of free T3 and significantly lower levels of free T4. While anti-TPO antibodies were significantly higher, anti-TG antibodies were significantly lower in women with preeclampsia. Likewise, anti-TPO antibodies were significantly higher and anti-TG antibodies were significantly lower in women with SP than in women with MP. In linear regression, preeclampsia was significantly associated with TSH (−0.675 IU/ml, P = 0.009), free T3 (0.977 pg/ml, P < 0.001), and free T4 (0.186 ng/dl, P < 0.001) levels. In contrast to anti-TG antibodies and TSH, Sudanese patients with preeclampsia had higher levels of T3 and T4 hormones and anti-TPO antibodies irrespective of parity, gestational age, and hemoglobin levels.

show abstract

High incidence of obstetric complications in Kassala Hospital, Eastern Sudan

Cited by 43 publications

References 11 publications

Estimation of Plasma D-Dimer Levels in Sudanese Women with Preeclampsia

Estimation of Plasma D-Dimer Levels in Sudanese Women with Preeclampsia

Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia

Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

Contact Info

Product

Resources

About