High‐intensity‐focused ultrasound and phase‐sensitive optical coherence tomography for high resolution surface acoustic wave elastography

Zhou, Kanheng; Le, Nhan; Huang, Zhihong; Li, Chunhui

doi:10.1002/jbio.201700051

Cited by 13 publications

(17 citation statements)

References 35 publications

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“…These results suggest that the disease progression at SMRSS = 2, with more dermal collagen accumulation, dominates the change in stiffness rather than the DT. This finding points to future techniques that can probe the biomechanical properties of the dermis, such as by increasing the excitation frequency of the elastic wave up to 5 kHz [37,38]. However, more work is needed to confirm this hypothesis and is the next step of our research.…”

Section: Discussionmentioning

confidence: 62%

Translational optical coherence elastography for assessment of systemic sclerosis

Liu

Assassi

Theodore

et al. 2019

Journal of Biophotonics

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Systemic sclerosis (SSc‐scleroderma) is an autoimmune disorder with high mortality rate that results in excessive accumulation of collagen in the skin and internal organs. Currently, the modified Rodnan Skin Score (mRSS) is the gold standard for evaluating the dermal thickening due to SSc. However, mRSS has noticeable inter‐ and intra‐observer variabilities as quantified by the interclass correlation coefficient (ICC: 0.6‐0.75). In this work, optical coherence elastography (OCE) combined with structural optical coherence tomography (OCT) image analysis was used to assess skin thickness in 12 SSc patients and healthy volunteers. Inter‐ (ICC: 0.62‐0.99) and intra‐observer (ICC > 0.90) assessment of OCT/OCE showed excellent reliability. Clinical assessments, including histologically assessed dermal thickness (DT), mRSS, and site‐specific mRSS (SMRSS) were also performed for further validation. The OCE and OCT results from the forearm demonstrated the highest correlation (OCE: 0.78, OCT: 0.65) with SMRSS. Importantly, OCE and OCT had stronger correlations with the histological DT (OCT: r = .78 and OCE: r = .74) than SMRSS (r = .57), indicating the OCT/OCE could outperform semi‐quantitative clinical assessments such as SMRSS. Overall, these results demonstrate that OCT/OCE could be useful for rapid, noninvasive and objective assessments of SSc onset and monitoring skin disease progression and treatment response.

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Section: Discussionmentioning

confidence: 62%

Translational optical coherence elastography for assessment of systemic sclerosis

Liu

Assassi

Theodore

et al. 2019

Journal of Biophotonics

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“…Based on the wavenumber‐frequency domain map, the phase velocity of Lamb waves can be derived through Equation :

C_{p} = \frac{ω}{k},

where C p is the phase velocity, ω is the angular frequency and k is the wavenumber. The phase velocity dispersion curve was then obtained by selecting the phase velocity with maximal intensity for corresponding frequency.…”

Section: Methodsmentioning

confidence: 99%

Assessment of corneal viscoelasticity using elastic wave optical coherence elastography

Jin

Zhou

Shen

et al. 2019

Journal of Biophotonics

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The corneal viscoelasticity have great clinical significance, such as the early diagnosis of keratoconus. In this work, an analysis method which utilized the elastic wave velocity, frequency and energy attenuation to assess the corneal viscoelasticity is presented. Using phase‐resolved optical coherence tomography, the spatial‐temporal displacement map is derived. The phase velocity dispersion curve and center frequency are obtained by transforming the displacement map into the wavenumber‐frequency domain through the 2D fast Fourier transform (FFT). The shear modulus is calculated through Rayleigh wave equation using the phase velocity in the high frequency. The normalized energy distribution is plotted by transforming the displacement map into the spatial‐frequency domain through the 1D FFT. The energy attenuation coefficient is derived by exponential fitting to calculate the viscous modulus. Different concentrations of tissue‐mimicking phantoms and porcine corneas are imaged to validate this method, which demonstrates that the method has the capability to assess the corneal viscoelasticity.

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“…Based on the wavenumber-frequency domain map, the phase velocity of Lamb waves can be derived through Eq. (9) [43,44]:…”

Section: In-vivo Healthy Rabbit Studymentioning

confidence: 99%

In-vivo 3D corneal elasticity using air-coupled ultrasound optical coherence elastography

Jin¹,

Khazaeinezhad²,

Zhu³

et al. 2019

Biomed. Opt. Express

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Corneal elasticity can resist elastic deformations under intraocular pressure to maintain normal corneal shape, which has a great influence on corneal refractive function. Elastography can measure tissue elasticity and provide a powerful tool for clinical diagnosis. Air-coupled ultrasound optical coherence elastography (OCE) has been used in the quantification of ex-vivo corneal elasticity. However, in-vivo imaging of the cornea remains a challenge. The 3D air-coupled ultrasound OCE with an axial motion artifacts correction algorithm was developed to distinguish the in-vivo cornea vibration from the axial eye motion in anesthetized rabbits and visualize the elastic wave propagation clearly. The elastic wave group velocity of in-vivo rabbit cornea was measured to be 5.96 ± 0.55 m/s, which agrees with other studies. The results show the potential of 3D air-coupled ultrasound OCE with an axial motion artifacts correction algorithm for quantitative in-vivo assessment of corneal elasticity.

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High‐intensity‐focused ultrasound and phase‐sensitive optical coherence tomography for high resolution surface acoustic wave elastography

Cited by 13 publications

References 35 publications

Translational optical coherence elastography for assessment of systemic sclerosis

Translational optical coherence elastography for assessment of systemic sclerosis

Assessment of corneal viscoelasticity using elastic wave optical coherence elastography

In-vivo 3D corneal elasticity using air-coupled ultrasound optical coherence elastography

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