High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise

Marquez, Cinthia Maria Saucedo; Vanaudenaerde, Bart M.; Troosters, Thierry; Wenderoth, Nicole

doi:10.1152/japplphysiol.00126.2015

Cited by 181 publications

(189 citation statements)

References 94 publications

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“…In the present study, both protocols led to energy stress, demonstrated by lactate which increased in both HIIE1.25 and HIIE2.5 immediately after exercise if standardized to basal values justifying, at least, the BDNF behavior immediately and 60 min after exercise (Table 2). These results are according to studies by Griffin et al (2011) and Saucedo Marquez et al (2015). However, there was no difference between HIIE1.25 and HIIE2.5 in BDNF response, even though the duration of HIIE was set differently in both protocols.…”

Section: Discussionsupporting

confidence: 90%

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Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Cabral-Santos¹,

Castrillón²,

Miranda³

et al. 2016

Front. Physiol.

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The purpose of this study was to compare the effects of two similar high-intensity intermittent exercises (HIIE) but different volume 1.25 km (HIIE1.25) and 2.5 km (HIIE2.5) on inflammatory and BDNF responses. Ten physically active male subjects (age 25.22 ± 1.74 years, body mass 78.98 ± 7.31 kg, height 1.78 ± 0.06 m, VO2peak 59.94 ± 9.38 ml·kg·min−1) performed an incremental treadmill exercise test and randomly completed two sessions of HIIE on a treadmill (1:1 min at vVO2max with passive recovery). Blood samples were collected at rest, immediately and 60-min after the exercise sessions. Serum was analyzed for glucose, lactate, IL-6, IL-10, and BDNF levels. Blood lactate concentrations was higher immediately post-exercise compared to rest (HIIE1.25: 1.69 ± 0.26–7.78 ± 2.09 mmol·L−1, and HIIE2.5: 1.89 ± 0.26–7.38 ± 2.57 mmol·L−1, p < 0.0001). Glucose concentrations did not present changes under the different conditions, however, levels were higher 60-min post-exercise than at rest only in the HIIE1.25 condition (rest: 76.80 ± 11.14–97.84 ± 24.87 mg·dL−1, p < 0.05). BDNF level increased immediately after exercise in both protocols (HIIE1.25: 9.71 ± 306–17.86 ± 8.59 ng.mL−1, and HIIE2.5: 11.83 ± 5.82–22.84 ± 10.30 ng.mL−1). Although both exercises increased IL-6, level percent between rest and immediately after exercise was higher in the HIIE2.5 than HIIE1.25 (30 and 10%; p = 0.014, respectively). Moreover, IL-10 levels percent increase between immediately and 60-min post-exercise was higher in HIIE2.5 than HIIE1.25 (37 and 10%; p = 0.012, respectively). In conclusion, both HIIE protocols with the same intensity were effective to increase BDNF and IL-6 levels immediately after exercise while only IL-10 response was related to the durantion of exercise indicanting the importance of this exercise prescription variable.

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Section: Discussionsupporting

confidence: 90%

“…Saucedo Marquez et al (2015) demonstrated that only one HIIE session was able to increase BDNF levels immediately after exercise performing a protocol with intervals of 1 min at 90% of maximal work load, altering with 1 min active rest (low load) during 20 min but a duration effect was not investigated.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Cabral-Santos¹,

Castrillón²,

Miranda³

et al. 2016

Front. Physiol.

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“…The contrary findings may be explained by the heterogeneous responses for the participants in the current study, or may suggest that other mechanism/s contributed to the observed exercise‐induced improvements in executive function. It has been suggested that the exercise‐induced upregulation of neurotransmitters such as dopamine, serotonin, norepinephrine and endorphine (Barenberg, ; Best, ; Meeusen, Watson, Hasegawa, Roelands, & Piacentini, ), as well as brain‐derived neurotropic factor (Saucedo Marquez, Vanaudenaerde, Troosters, & Wenderoth, ) play a crucial role in improving executive function (Barenberg, ; Robbins & Arnsten, ).…”

Section: Discussionmentioning

confidence: 99%

“…Understanding the mechanism(s) of action will enable the identification of the optimal exercise paradigm for enhancing executive function. For example, while moderate intensity exercise is most effective for increasing cerebral blood flow (Ogoh & Ainslie, ), high‐intensity intermittent exercise may elicit greater elevations in serum BDNF (brain‐derived neurotrophic factor; Saucedo Marquez et al, ). Furthermore, compared to continuous and moderate intensity exercise, short periods of intense exercise have been shown to result in greater elevations of BDNF and peripheral catecholamines, and can improve vocabulary learning by 20% in just one week (Winter et al, ).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of exercise posture on executive function in transient ischemic attack patients

et al. 2017

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DisclaimerThe University of Gloucestershire has obtained warranties from all depositors as to their title in the material deposited and as to their right to deposit such material.The University of Gloucestershire makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited.The University of Gloucestershire makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights.The University of Gloucestershire accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. PLEASE SCROLL DOWN FOR TEXT. 1 ACUTE EFFECTS OF EXERCISE POSTURE ON EXECUTIVE FUNCTION IN TRANSIENT ISCHEMIC ATTACK PATIENTS AbstractIn patients with stroke or transient ischaemic attacks (TIA), a decline in executive function may limit an individual's ability to process motor tasks and re-learn motor skills. The purpose of this study was to assess the acute effect of exercise posture (seated vs. supine cycle ergometry) on executive function and prefrontal cortex perfusion, in patients with TIA. Eleven TIA patients (65±10y) and 15 age-matched, healthy-controls (HC; 62±7y) completed two graded exercise tests to maximal functional capacity (1 x seated; 1 x supine) and two 30-minute sub-maximal exercise tests (1 x seated, 1 x supine). Executive function was assessed prior-to and following (1.5-min Post, 15-min Post) the submaximal exercise tests using a Stroop Task.Prefrontal cortex perfusion (total hemoglobin) was continuously recorded using near infrared spectroscopy. Group had no significant influence on prefrontal cortex perfusion (P > .05). In conclusion, executive function improves to a similar extent in TIA and age-matched, healthy-controls following an acute bout of exercise, regardless of exercise posture (seated vs. supine). As acute improvements in executive function were maintained for 15 minutes, there could be an important window of opportunity for assigning executive tasks following exercise rehabilitation for patients with TIA.

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“…Regarding HIIE, it was found only the study of Saucedo Marquez et al (2015) that verified BDNF behaviour in humans submitted to HIIE. Saucedo Marquez et al (2015) showed that BDNF concentrations did not reduce during recovery period. Most studies in the literature involving BDNF and exercise refer to moderate intensity aerobic exercise.…”

Section: Discussionmentioning

confidence: 99%

Influence to high-intensity intermittent and moderate-intensity continuous exercise on indices of cardio-inflammatory health in men

et al. 2016

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The aim of this study was to evaluate the influence to acute exercises performed in different intensities with volume equalized (5 km) on indices of cardio-inflammatory health. Twelve physically active male subjects (age, 23.22±5.47 years; height, 174.75±5.80 m; weight, 75.13±6.61 kg; maximal oxygen uptake, 52.92 mL/kg/min), after determination of peak oxygen uptake (VO2Peak) and the speed associated with VO2Peak (sVO2Peak), completed two randomly experimental trials: high-intensity intermittent exercise (HIIE: 1:1 at 100% sVO2Peak) and moderate-intensity continuous exercise (MICE: 70% sVO2Peak). Brain-derived neurotrophic factor (BDNF), adiponectin and plasminogen inhibitor-1 (PAI-1) data were analyzed pre, immediately, and 60 min after the exercise session. Statistical analysis comparisons between moments and between HIIE and MICE were performed using a mixed model and statistical and significance was set at <5%. PAI-1 presented an effect for time from pre to immediately after exercise moment (P<0.018) and from immediately to 60 min after exercise moment (P<0.001) only in MICE. BDNF presented an effect for time from pre to immediately after exercise to HIIE (P<0.022) and from immediately to 60 min after exercise to MICE (P<0.034). HIIE promotes BDNF increase and that there is negative correlation between PAI-1 concentrations and BDNF in both protocols in healthy sportsmen, favoring an anti-atherogenic profile.

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High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise

Cited by 181 publications

References 94 publications

Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume

Acute effects of exercise posture on executive function in transient ischemic attack patients

Influence to high-intensity intermittent and moderate-intensity continuous exercise on indices of cardio-inflammatory health in men

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