High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome

Steckling, Flávia Mariel; Farinha, Juliano Boufleur; Figueiredo, Felipe da Cunha; Santos, Daniela Lopes dos; Bresciani, Guilherme; Filho, Nélson Alexandre Kretzmann; Stefanello, Sílvio Terra; Courtes, Aline Alves; Beck, Maristela de Oliveira; Cardoso, Manuela Sangoi; Moresco, Rafael Noal; Soares, Félix Alexandre Antunes

doi:10.1080/13813455.2018.1437750

Cited by 30 publications

(28 citation statements)

References 48 publications

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“…In our study, 4 weeks of HIIT performed twice a week increased VO 2Peak and time to exhaustion in postmenopausal obese women. In fact, our results are in the line of previous data who demonstrated the role of HIIT on the positive adaptations of cardiorespiratory fitness in postmenopausal women …”

Section: Discussionsupporting

confidence: 93%

“…Interestingly, lower IL‐6 levels and higher IL‐10, and IL‐1ra concentrations at rest were observed after 4 weeks of HIIT. Similar to us, previous results also found a significantly reduction in plasmatic proinflammatory cytokines (MCP‐1, IL‐6, and TNF‐α) in postmenopausal women with metabolic syndrome, while IL‐10 levels were upregulated after HIIT over 2‐12 weeks . The anti‐inflammatory adaptations of exercise has been associated with lower rates of the chronic diseases development in postmenopausal women, indicating the great contribution of HIIT to the health improvements.…”

Section: Discussionsupporting

confidence: 85%

“…Recently, high intensity interval training (HIIT) emerges as a time‐efficient alternative compared with traditional exercise recommendations to promote positive metabolic and physiological adaptations with a lower commitment of week time . Although there is growing evidence that HIIT improves inflammation and cardiometabolic health, there is less evidence of the impact of HIIT on systemic inflammation in postmenopausal obese women . The high intensity adopted in HIIE may induce an acute proinflammatory response in postmenopausal women that can attenuate the positive chronic adaptations of HIIT.…”

Section: Introductionmentioning

confidence: 99%

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Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

et al. 2018

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This study investigated the acute and chronic effects of 4 weeks of High Intensity Interval Training (HIIT) on cytokines and oxidative stress markers in postmenopausal obese women. Ten post‐menopause sedentary obese women (age 58.25 ± 3.10 years; BMI 31.70 ± 1.34 kg/m²) performed 4 weeks of high intensity interval exercise (60 seconds of effort at 85%‐90% Maximal Heart Rate interspersed by 75 seconds of recovery at sessions of 40% Maximal Heart Rate) twice a week. Blood samples were collected before and immediately after the first and the last (8th) high intensity interval exercise (HIIE) session to analyze interleukin(IL)‐1β, IL‐1ra, IL‐6, IL‐10, monocyte chemoattractant protein‐1 (MCP‐1) levels and lipid peroxidation (TBARS), nitrites, and advanced oxidation protein products (AOPP). An elevation in MCP‐1, IL‐6, and IL‐10 levels and in TBARS and AOPP occurred immediately after the first HIIE. After 4 weeks of HIIT, the participants presented lower levels of IL‐6 and higher amounts of IL‐1ra and IL‐10 at rest. The last HIIE session induced an elevation only in IL‐6, IL‐10, and IL‐1ra levels, but not in MCP‐1, IL‐1β, and TBARS levels. In conclusion, HIIT induced anti‐inflammatory effects in postmenopausal obese women, with little changes in oxidative stress markers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

et al. 2018

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“…HR and BP are powerful predictors of total cardiovascular mortality (32). Decreased vascular resistance and catecholamine level are related to the reduction of HR and BP after exercise (33). As to the reduction in HR and BP through HIIT, our findings correspond to those of (31, 32), while they are contradictory with the results of (34).…”

Section: Resultscontrasting

confidence: 94%

The Effect of All-Extremity High-Intensity Interval Training on Plasma Pentraxin 3 in Young Overweight and Obese Women

et al. 2019

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Background: In obese individuals, chronic inflammation is associated with atherosclerosis and cardiovascular diseases. This inflammation may be reduced by anti-inflammatory proteins like pentraxin 3 (PTX3). High-intensity interval training (HIIT) mostly with weight bearing might also alleviate this inflammation. This type of exercise may be limited in obese individuals due to their excessive body mass, muscular weakness or joints pain. Whether non-weight bearing HIIT can increase these anti-inflammatory proteins in obese individuals is not clear yet. Objectives: The objective of this study was to assess the effect of non-weight bearing all-extremity HIIT (all ex. HIIT) on antiinflammatory proteins like PTX3. Methods: In this cross-sectional semi-experimental study, 30 overweight and obese female participants with the mean age of 20.50 ± 1.50 years and the mean weight of 80.70 ± 13.70 kg were randomly assigned to all ex. HIIT and control groups. Training consisted of 4 × 4 min 85%-90% max HR, and 3 × 3 recovery by 70% max HR with upper and lower body training in a simultaneous manner (four sessions per week for 10 weeks). PTX3, interleukin10 (IL10), tumor necrosis factor alpha (TNFα), lipid profile, glycemic profile, heart rate (HR) and blood pressure (BP) were assessed before and after the intervention. Results: At the end of the intervention, no significant difference was observed in PTX3 (P = 0.47), IL10 (P = 0.67) and TNFα (P = 0.92) levels between the groups. Low-density lipoprotein (LDL) decreased by 13.5% in the all ex. HIIT group, while the triglyceride (TG), cholesterol (CHOL), high-density lipoprotein (HDL) and glycemic profiles remained unchanged in both groups. HR and systolic and diastolic BP decreased by 12.2%, 2.3% and 6%, respectively, in the all ex. HIIT group, while they remained unchanged in the control group. There was no significant change in PTX3, but as to its correlation with IL10 and HDL a slight change is observed. Conclusions: All ex. HIIT may be a safe exercise that decreases LDL, HR and systolic and diastolic BP in overweight and obese individuals unable to perform weight-bearing HIIT.

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“…HIIT is an exercise pattern that alternates high-intensity exercise periods with low-intensity recovery periods. High intensity is defined as above 80% HRmax 6 , and it is generally more common to use intensity greater than 80–95% HRmax 7 – 10 . Dynamic exercise intensity recovery is the moderate intensity of 50–60% HRR or of 60–70% VO 2 peak 11 .…”

Section: Introductionmentioning

confidence: 99%

Land vs. water HIIE effects on muscle oxygenation and physiological parameter responses in postmenopausal women

Chien

Kan

Liao

et al. 2020

Sci Rep

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Muscle oxygenation (MO) status is the dynamic balance between O 2 utilization and O 2 delivery. Low-impact high-intensity interval exercise MO responses in the exercise and recovery stage are still unclear. We compared the differences in MO and physiological parameters between high-intensity interval water-based exercise (WHIIE) and high-intensity interval land bike ergonomic exercise (LBEHIIE) in postmenopausal women. Eleven postmenopausal women completed WHIIE or LBEHIIE in counterbalanced order. Eight sets were performed and each exercise set included high intensity with 80% heart rate reserve (HRR) in 30 s and dynamic recovery with 50% HRR in 90 s. Muscle tissue oxygen saturation index (TSI), total hemoglobin (tHb), oxy-hemoglobin (O 2 Hb), and deoxy-hemoglobin (HHb) were recorded. Blood lactate, heart rate and rating of perceived exertion (RPE) were measured at pre and post-exercise. Under similar exercise intensity, RPE in WHIIE was lower than that in LBEHIIE. The heart rate in WHIIE was lower than that in LBEHIIE at 1 and 2 min post-exercise. During the dynamic recovery, TSI, tHb, and O2Hb in water were higher than on land. A negative correlation was found between the change in TSI and lactate concentration (r = − 0.664). WHIIE produced greater muscle oxygenation during dynamic recovery. Muscle TSI% was inversely related to blood lactate concentration during exercise in water. Women become estrogen deficient in the post-menopausal period. This increases the risk for cardiovascular disease 1,2. Numerous studies demonstrated that higher than moderate intensity exercise can reduce cardiovascular disease and the overall risk of death 3,4. However, lack of time is one of the most important obstacles to regular exercise 5. High-intensity interval training (HIIT) can achieve cardiovascular stimulation intensity within a short time period. HIIT is an exercise pattern that alternates high-intensity exercise periods with lowintensity recovery periods. High intensity is defined as above 80% HRmax 6 , and it is generally more common to use intensity greater than 80-95% HRmax 7-10. Dynamic exercise intensity recovery is the moderate intensity of 50-60% HRR or of 60-70% VO 2 peak 11. Previous studies demonstrated that HIIT on land can effectively reduce post-menopausal women's abdominal fat 12 , inflammatory markers 10 , insulin sensitivity, oxidative stress and cardiovascular disease risk 13. Although there are many benefits to on-land HIIT, participants must endure higher joint impact and the risk for acute muscle soreness or muscle damage with weight-bearing exercise on land 14,15. Furthermore, a decline in muscle power and muscle strength 16 and increase in deleterious musculoskeletal conditions 17 occurs after middle-age. The high-impact jumping exercise on land is too burdensome for postmenopausal women. The buoyancy of water can reduce the joint load and joint impact caused by exercise. Exercising in shallow water it will increase the resistance in the lower limbs, so that the lower limb workload increases. Bicyc...

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High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome

Cited by 30 publications

References 48 publications

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

The Effect of All-Extremity High-Intensity Interval Training on Plasma Pentraxin 3 in Young Overweight and Obese Women

Land vs. water HIIE effects on muscle oxygenation and physiological parameter responses in postmenopausal women

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