High-level mupirocin resistance in methicillin-resistant staphylococci isolated from dogs and cats

Kizerwetter-Świda, Magdalena; Chrobak-Chmiel, Dorota; Rzewuska, Magdalena

doi:10.1186/s12917-019-1973-y

Cited by 21 publications

(20 citation statements)

References 27 publications

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“…Its prolonged and frequently unjustified use in humans has led to the emergence of mupirocin-resistant (mupR) S. aureus in Africa [36]. The use of mupirocin is limited in veterinary medicine in some countries, but cases of high-level resistance to mupirocin have been reported in MRSA isolates from dogs in Poland [37]. In the present study, two mupirocin MRSA strains were isolated from turkeys.…”

Section: Discussionmentioning

confidence: 82%

Methicillin-Resistant Staphylococcus aureus (MRSA) in Poultry Species in Algeria: Long-Term Study on Prevalence and Antimicrobial Resistance

Benrabia

Hamdi

Shehata

et al. 2020

Veterinary Sciences

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Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a serious impact on human and veterinary public health. To determine antibiotic resistance of MRSA in poultry, 4248 nasal swabs were collected from 840 poultry farms in 18 different Wilayas (provinces) of Algeria. Swabs were collected between 2011 and 2018 from breeding hens, laying hens, broilers, and turkeys. Identification was carried out by the classical culture methods, and the disc diffusion test was used to determine the antibiotic resistance patterns. S. aureus was isolated from 477 (56.8%) farms, and flock prevalence was 52.8%, 48.8%, 48.4%, and 75.6% in breeding hens, laying hens, broilers, and turkeys, respectively. MRSA was isolated from 252 (30%) farms and flock prevalence was 22%, 33.5%, 27.4%, and 36%, respectively. As expected, all MRSA isolates were resistant to cefoxitin, penicillin G, amoxicillin/clavulanic acid, and oxacillin. High levels of resistance were found for tetracycline (82.5%), erythromycin (70.6%), clindamycin (68.6%), and ciprofloxacin (50%). Almost all isolates were susceptible to vancomycin (100%) and mupirocin and rifampicin (99.2%), followed by chloramphenicol (82.3%), and gentamicin (76%). This moderate proportion of MRSA in poultry poses a considerable risk to public health. The results of this study highlight the need for control programs that encompass primary animal production and the food chain to mitigate contamination and spread of MRSA in the poultry industry of Algeria, and consequently to humans.

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Section: Discussionmentioning

confidence: 82%

Methicillin-Resistant Staphylococcus aureus (MRSA) in Poultry Species in Algeria: Long-Term Study on Prevalence and Antimicrobial Resistance

Benrabia

Hamdi

Shehata

et al. 2020

Veterinary Sciences

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“…Rossi and colleagues reported the transfer of Mup R from S. haemolyticus clinical isolates to S. aureus suggesting that S. haemolyticus act as a reservoir for Mup R [67]. Not only in humans but high levels of Mup R were recorded in MRSH in healthy and diseased dogs [113,114].…”

Section: Mupirocinmentioning

confidence: 99%

Clinical Infections, Antibiotic Resistance, and Pathogenesis of Staphylococcus haemolyticus

et al. 2022

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Staphylococcus haemolyticus (S. haemolyticus) constitutes the main part of the human skin microbiota. It is widespread in hospitals and among medical staff, resulting in being an emerging microbe causing nosocomial infections. S. haemolyticus, especially strains that cause nosocomial infections, are more resistant to antibiotics than other coagulase-negative Staphylococci. There is clear evidence that the resistance genes can be acquired by other Staphylococcus species through S. haemolyticus. Severe infections are recorded with S. haemolyticus such as meningitis, endocarditis, prosthetic joint infections, bacteremia, septicemia, peritonitis, and otitis, especially in immunocompromised patients. In addition, S. haemolyticus species were detected in dogs, breed kennels, and food animals. The main feature of pathogenic S. haemolyticus isolates is the formation of a biofilm which is involved in catheter-associated infections and other nosocomial infections. Besides the biofilm formation, S. haemolyticus secretes other factors for bacterial adherence and invasion such as enterotoxins, hemolysins, and fibronectin-binding proteins. In this review, we give updates on the clinical infections associated with S. haemolyticus, highlighting the antibiotic resistance patterns of these isolates, and the virulence factors associated with the disease development.

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“…This has inspired debates concerning whether treatments such as these should be limited to human use. However, it is necessary to combine limitations on antibiotic use with additional strategies to control the proliferation of these resistant strains [28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of multidrug-resistant coagulase-positive staphylococci in canine and feline dermatological patients over a 10-year period: a retrospective study

Burke

Santoro

2023

Microbiology

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Coagulase-positive staphylococci (CPS) are common cutaneous pathogens often requiring multiple courses of antibiotics, which may facilitate selection for methicillin-resistant (MR) and/or multidrug-resistant (MDR) strains. To determine the prevalence of canine and feline MR/MDR CPS associated with skin diseases, medical records were retrospectively searched from April 2010 to April 2020. Pets with at least one positive culture for CPS were selected. Age, sex, antimicrobial sensitivity, previous history of antimicrobial/immunomodulatory medications and methicillin resistance/multidrug resistance status were recorded. Staphylococcus pseudintermedius (SP) (575/748) and Staphylococcus schleiferi (SS) (159/748) in dogs, and Staphylococcus aureus (12/22) in cats, were the most common CPS isolated. Three hundred and twenty-three out of 575 isolates were MR-SP (56.2 %), 304/575 were MDR-SP (52.8 %), 100/159 were MR-SS (62.9 %) and 71/159 were MDR-SS (44.6 %). A trend analysis showed a significant increase of resistance to oxacillin and chloramphenicol for S. pseudintermedius (r=0.86, 0.8; P=0.0007, 0.0034, respectively). Major risk factors for MDR-SP included oxacillin resistance (OR: 3; 95 % CI: 1.4–6.5; P=0.0044), positivity for PBP2a (OR: 2.3; 95 % CI: 1–5; P=0.031) and use of antibiotics in the previous year (OR: 2.8; 95 % CI: 1.3–5.8; P=0.0071). Oxacillin resistance was identified as a major risk factor for MDR-SS (OR: 8.8; 95 % CI: 3.6–21.1; P<0.0001). These results confirmed the widespread presence of MR/MDR CPS in referred dermatological patients. Judicious antibiotic use, surveillance for MR/MDR infections and consideration of alternative therapies are crucial in mitigating the development of resistant strains.

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High-level mupirocin resistance in methicillin-resistant staphylococci isolated from dogs and cats

Cited by 21 publications

References 27 publications

Methicillin-Resistant Staphylococcus aureus (MRSA) in Poultry Species in Algeria: Long-Term Study on Prevalence and Antimicrobial Resistance

Methicillin-Resistant Staphylococcus aureus (MRSA) in Poultry Species in Algeria: Long-Term Study on Prevalence and Antimicrobial Resistance

Clinical Infections, Antibiotic Resistance, and Pathogenesis of Staphylococcus haemolyticus

Prevalence of multidrug-resistant coagulase-positive staphylococci in canine and feline dermatological patients over a 10-year period: a retrospective study

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