“…Several examples can be found in the open literature concerning the application of surrogate meta-models in reliability problems. In (Bucher and Most, 2008;Gavin and Yau, 2008;Liel et al, 2008), polynomial Response Surfaces (RSs) are employed to evaluate the failure probability of structural systems; in Fong et al, 2009;Mathews et al, 2009), linear and quadratic polynomial RSs are employed for performing the reliability analysis of T-H passive systems in advanced nuclear reactors; in (Deng, 2006;Hurtado, 2007;Cardoso et al, 2008;Cheng et al, 2008), learning statistical models such as Artificial Neural Networks (ANNs), Radial Basis Functions (RBFs) and Support Vector Machines (SVMs) are trained to provide local approximations of the failure domain in structural reliability problems; in (Volkova et al, 2008;Marrel et al, 2009), Gaussian meta-models are built to calculate global sensitivity indices for a complex hydrogeological model simulating radionuclide transport in groundwater.…”