High Pathogenicity of Nipah Virus from<i>Pteropus lylei</i>Fruit Bats, Cambodia

Gaudino, Maria; Aurine, Noémie; Dumont, Claire; Fouret, Julien; Ferren, Marion; Mathieu, Cyrille; Reynard, Olivier; Volchkov, Viktor E.; Legras-Lachuer, Catherine; Georges‐Courbot, Marie‐Claude; Horvat, Branka

doi:10.3201/eid2601.191284

Cited by 16 publications

(18 citation statements)

References 43 publications

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“…The COVID‐19 is not the first instance of a humanitarian crisis caused by a zoonotic disease. Recently, zoonotic viruses such as H1N1, Nipah (NiV), SARS‐CoV and MERS‐CoV have already infected thousands of humans in multiple countries (Bonilla‐Aldana et al., 2020; Gaudino et al., 2020; Gumel et al., 2004; Wang & Eaton, 2007). Since it is evident that the interactions between environment, animals and humans play an essential role in the transmission of zoonotic and emerging diseases, an integrative One Health approach must be followed to develop disease resilience strategies.…”

Section: Introductionmentioning

confidence: 99%

Multisectoral one health approach to make aquaculture and fisheries resilient to a future pandemic‐like situation

Jamwal

Phulia

2020

Fish and Fisheries

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The COVID‐19 pandemic, caused by the SARS‐CoV‐2, has presented itself as a wicked problem where both the disease and its containment measures have caused significant human suffering. The pandemic has also affected every aspect of aquaculture and capture fisheries. Zoonotic origin of the SARS‐CoV‐2 and its containment measures, such as restrictions on the mobility of people, social distancing and ban on public gathering, have disrupted fish production, supply chain, consumer behaviour and perception for fish as a food item. The debilitating effect of COVID‐19 on the global economy has also left people with less dispensable income, which can translate to poor fish sales in the upcoming years. Therefore, the effects of COVID‐19 on society are not only a medical issue but have more profound and long‐lasting socioeconomic consequences. The current article reviews the existing literature across multiple disciplines to determine the effects of the COVID‐19 pandemic on multiple aspects of the aquaculture and fishing industry; aquaculture and capture fishery, post‐harvest processing of fish, supply chain and consumer behaviour. The article also provides recommendations for making different aspects of aquaculture and fisheries resilient to a future pandemic‐like situation. The recommendations are inspired by the principles of One Health that range from biological to socioeconomic aspects of the sector. A One Health approach is a collaborative effort from professionals belonging, but not limited, to the disciplines of medicine, veterinary, environment, economics, education and social sciences to make policy‐level interventions for problems that can be difficult to address using conventional approach.

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Section: Introductionmentioning

confidence: 99%

Multisectoral one health approach to make aquaculture and fisheries resilient to a future pandemic‐like situation

Jamwal

Phulia

2020

Fish and Fisheries

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“…According to our results, although the time and geographical span of the NiV outbreaks are wide, the G proteins from the two viral genotypes had adequately protective effects. All human NiV outbreaks that occurred after 2000 were due to the Bangladesh strains, but there is also a recently described (2003) NiV isolate in Cambodia that belongs to the NiV Malaysia clade [6]. When developing the NiV vaccine using a G protein, the differences in strains may not affect the protective effect of the vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic and can cause fatal human diseases. The Pteropus bat species appear to be the major natural reservoir hosts for henipaviruses (HNVs), and all bat isolates of HeV and NiV have been derived from the genus Pteropus's bats [2][3][4][5][6]. HeV was first isolated after an outbreak in the town of Hendra, Australia in 1994.…”

Section: Introductionmentioning

confidence: 99%

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice

Wang

et al. 2020

Viruses

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The genus Henipavirus (HNVs) includes two fatal viruses, namely Nipah virus (NiV) and Hendra virus (HeV). Since 1994, NiV and HeV have been endemic to the Asia-Pacific region and responsible for more than 600 cases of infections. Two emerging HNVs, Ghana virus (GhV) and Mojiang virus (MojV), are speculated to be associated with unrecognized human diseases in Africa and China, respectively. Despite many efforts to develop vaccines against henipaviral diseases, there is presently no licensed human vaccine. As HNVs are highly pathogenic and diverse, it is necessary to develop universal vaccines to prevent future outbreaks. The attachment enveloped glycoprotein (G protein) of HNVs mediates HNV attachment to the host cell's surface receptors. G proteins have been used as a protective antigen in many vaccine candidates for HNVs. We performed quantitative studies on the antibody responses elicited by the G proteins of NiV, HeV, GhV, and MojV. We found that the G proteins of NiV and HeV elicited only a limited cross-reactive antibody response. Further, there was no cross-protection between MojV, GhV, and highly pathogenic HNVs. We then constructed a bivalent vaccine where the G proteins of NiV and HeV were fused with the human IgG1 Fc domain. The immunogenicity of the bivalent vaccine was compared with that of monovalent vaccines. Our results revealed that the Fc-based bivalent vaccine elicited a potent antibody response against both NiV and HeV. We also constructed a tetravalent Fc heterodimer fusion protein that contains the G protein domains of four HNVs. Immunization with the tetravalent vaccine elicited broad antibody responses against NiV, HeV, GhV, and MojV in mice, indicating compatibility among the four antigens in the Fc-fusion protein. These data suggest that our novel bivalent and tetravalent Fc-fusion proteins may be efficient candidates to prevent HNV infection.

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“…Cell culture from Pteropus bat flying fox was generated from a wing-membrane skin biopsy of a female specimen of P. medius (known also as Indian flying fox and P. giganteus, belonging to Yinpterochiroptera suborder) (Figure 1), collected in the Tiergarten Schönbrunn (Vienna, Austria), during the regularly veterinary check, as previously described (Gaudino et al, 2020). Briefly, sample was washed with sterile PBS and transferred into freezing medium Cryo-SFM (PromoCell Bioscience) in dry ice, for the shipment from the zoo.…”

Section: Pteropus Medius Sampling and Cell Generationmentioning

confidence: 99%

Sequencing the Genome of Indian Flying Fox, Natural Reservoir of Nipah Virus, Using Hybrid Assembly and Conservative Secondary Scaffolding

et al. 2020

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High Pathogenicity of Nipah Virus fromPteropus lyleiFruit Bats, Cambodia

Cited by 16 publications

References 43 publications

Multisectoral one health approach to make aquaculture and fisheries resilient to a future pandemic‐like situation

Multisectoral one health approach to make aquaculture and fisheries resilient to a future pandemic‐like situation

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice

Sequencing the Genome of Indian Flying Fox, Natural Reservoir of Nipah Virus, Using Hybrid Assembly and Conservative Secondary Scaffolding

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