High performance ion mobility spectrometry as a fast and low cost green analytical technology part I: analysis of nutritional supplements

Krueger, Clinton A.; Midey, Anthony J.; Kim, Taeman; Osgood, Mark; Wu, Jianglin; Wu, Ching

doi:10.1007/s12127-011-0072-y

Cited by 13 publications

(1 citation statement)

References 53 publications

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“…The electrospray needle was held at 2.90 kV above the drift potential of 8.00 kV. Analyte ions were continuously infused through the electrospray needle by applying a potential of 10.5 kV at a current limit of 1 μA to maintain a stable spray. − This resulted in the ESI solvent being removed from the ionized droplets in the ∼6.00 cm long desolvation region. Analyte ions were subsequently introduced into the drift region held at a constant temperature of 150 °C.…”

Section: Methodsmentioning

confidence: 99%

Identity Efficiency for High-Performance Ambient Pressure Ion Mobility Spectrometry

Kanu

Leal

2016

Anal. Chem.

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A new approach to reduce the false-positive responses commonly encountered in the field when drugs and explosives are detected is reported for an electrospray ionization high-performance ion mobility spectrometry (ESI-HPIMS). In this article, we report on the combination of reduced mobility and the width-at-half-height of a peak to give a new parameter called conditional reduced mobility (CRM). It was found that the CRM was capable of differentiating between real drugs peaks from that of a false-positive peak and may help to reduce false-positive rates. This effect was demonstrated using 11 drugs (amphetamine, cannabidiol, cocaine, codeine, heroine, methamphetamine, morphine, phentermine, L-phenylepherine, proglitazone, and rosiglitazone) and seven interferences chosen from off-the-shelf products. This report determined and compared CRM, resolving power (R(m)), and diffusion-limited conditional theoretical reduced mobility (DLCTRM) for ESI-HPIMS. The most important parameters for determining CRM are reduced mobility and width-at-half-height of a peak. There is a specific optimum voltage, gate pulse width, resolving power, and now CRM for each ion. DLCTRM indicate the optimum reduced mobility that is not normally possible under field conditions. CRM predicts the condition at which a target compound can be differentiated from a false-positive response. This was possible because different ions exhibits different drifting patterns and hence a different peak broadening phenomenon inside an ion mobility tube. Reduced mobility for target compounds reported were reproducible to within 2% for ESI-HPIMS. The estimated resolving power for the ESI-HPIMS used in this study was 61 ± 0.22. Conditional reduced mobility introduced in this paper show differences between target compounds and false-positive peaks as high as 74%, as was the case for cannabidiol and interference #1 at 70 μs gate pulse width.

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Section: Methodsmentioning

confidence: 99%

Identity Efficiency for High-Performance Ambient Pressure Ion Mobility Spectrometry

Kanu

Leal

2016

Anal. Chem.

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Ion mobility spectrometry as a high-throughput analytical tool in occupational pyrethroid exposure

Armenta

Blanco

2011

Anal Bioanal Chem

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The capabilities of ion mobility spectrometry (IMS) as a high throughput and green analytical tool in the occupational health and safety control, using pyrethroids as models has been evidenced. The method used for dermal and inhalation exposure assessment is based on the passive pyrethroid sampling using Teflon membranes, direct thermal extraction of the pyrethroids, and measurement of the vaporized analytes by IMS without reagent and solvent consumption. The IMS signatures of the studied synthetic pyrethroids under atmospheric pressure chemical ionization by investigating the formed negative ion products have been obtained. The main advantages of the proposed procedure are related to the obtained limits of detection, ranging from 0.08 to 5 ng, the simplicity of measurement, the lack of sample treatment, and therefore, solvent consumption and waste generation, and finally, the speed of analysis.

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Method validation parameters for drugs and explosives in ambient pressure ion mobility spectrometry

Sedwick

Massey

Codio

et al. 2017

Int. J. Ion Mobil. Spec.

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High performance ion mobility spectrometry as a fast and low cost green analytical technology part I: analysis of nutritional supplements

Cited by 13 publications

References 53 publications

Identity Efficiency for High-Performance Ambient Pressure Ion Mobility Spectrometry

Identity Efficiency for High-Performance Ambient Pressure Ion Mobility Spectrometry

Ion mobility spectrometry as a high-throughput analytical tool in occupational pyrethroid exposure

Method validation parameters for drugs and explosives in ambient pressure ion mobility spectrometry

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