High-performance thin-layer chromatography coupled with HPLC-DAD/HPLC-MS/MS for simultaneous determination of bisphenol A and nine brominated analogs in biological samples

Liu, Aifeng; Shen, Zhaoshuang; Li, Yuan; Xu, Mengmeng; Zhao, Zongshan; Liang, Xia

doi:10.1007/s00216-018-1492-x

Cited by 14 publications

(2 citation statements)

References 46 publications

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“…Nitrogen was used as a cover gas and auxiliary gas. The gas temperature was 350°C, the nebuliser was 40 psi, the gas flow was 10 L/min, and the capillary was 4500 V. Data were analysed using Qualitative Analysis B.06.00 software (Agilent, CA, USA) ( 43 ).…”

Section: Methodsmentioning

confidence: 99%

Proton Transfer From Ligands Activates Extranuclear-Initiated Estrogen Receptor Signaling

Medina-Gali,

Martinez-Pinna,

Marroqui

et al. 2023

Preprint

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Ligand binding to estrogen receptors (ER), ERα and ERβ, controls the physiology of estrogen-responsive tissues through nuclear and extranuclear initiated pathways. We have found that ligands activate the extranuclear pathway by a mechanism involving proton transfer. The low affinity ligand and widespread endocrine disruptor Bisphenol-A (BPA) initiated nuclear and extranuclear actions. Concentrations similar to the receptor affinity initiated the nuclear pathway, whereas much lower concentrations initiated the extranuclear pathway. Experiments in different cell types using deuterated molecules of BPA and the ERβ agonist, diarylpropionitrile (DPN), indicated that a proton transfer from the hydroxyl groups to an amino acid acceptor within the ligand binding domain switches the extranuclear pathway. Activation of this pathway elicited a pattern of protein interactions with ERβ that regulated most of the important cellular functions. Thus, the extranuclear actions of ERβ are initiated by a molecular mechanism different from that of nuclear actions. This mechanism may work for other ligands and nuclear receptors.

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Section: Methodsmentioning

confidence: 99%

Proton Transfer From Ligands Activates Extranuclear-Initiated Estrogen Receptor Signaling

Medina-Gali,

Martinez-Pinna,

Marroqui

et al. 2023

Preprint

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“…However, the conventional column chromatography combined with diode array detector (DAD) [19] or evaporative light scattering detector (ELSD) [20] detector do not satisfy the needs required for accurate and rapid analysis of complex components due to low peak capacity, time-consumption, and low sensitivity. Currently, the high-throughput and high-resolution UPLC-Q-TOF-MS, and ultra-fast and high-sensitivity UFLC-MS/MS systems easily achieve this goal, and are thus are employed as powerful tools for investigating the chemical constituents in complex Chinese medicine [21,22].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive and Rapid Quality Evaluation Method of Traditional Chinese Medicine Decoction by Integrating UPLC-QTOF-MS and UFLC-QQQ-MS and Its Application

Chen

Jiang

et al. 2019

Molecules

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Decoction is one of the oldest forms of traditional Chinese medicine and it is widely used in clinical practice. However, the quality evaluation and control of traditional decoction is a challenge due to the characteristics of complicated constituents, water as solvent, and temporary preparation. ShenFu Prescription Decoction (SFPD) is a classical prescription for preventing and treating many types of cardiovascular disease. In this article, a comprehensive and rapid method for quality evaluation and control of SFPD was developed, via qualitative and quantitative analysis of the major components by integrating ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry and ultra-fast-performance liquid chromatography equipped with triple quadrupole mass spectrometry. Consequently, a total of 39 constituents were tentatively identified in qualitative analysis, of which 21 compounds were unambiguously confirmed by comparing with reference substances. We determined 13 important constituents within 7 min by multiple reaction monitoring. The validated method was applied for determining five different proportion SFPDs. It was found that different proportions generated great influence on the dissolution of constituents. This may be one of the mechanisms for which different proportions play different synergistic effects. Therefore, the developed method is a fast and useful approach for quality evaluation of SFPD.

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An ultrasensitive fluorescent aptasensor based on truncated aptamer and AGET ATRP for the detection of bisphenol A

Guo

Tang

et al. 2019

Anal Bioanal Chem

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High-performance thin-layer chromatography coupled with HPLC-DAD/HPLC-MS/MS for simultaneous determination of bisphenol A and nine brominated analogs in biological samples

Cited by 14 publications

References 46 publications

Proton Transfer From Ligands Activates Extranuclear-Initiated Estrogen Receptor Signaling

Proton Transfer From Ligands Activates Extranuclear-Initiated Estrogen Receptor Signaling

A Comprehensive and Rapid Quality Evaluation Method of Traditional Chinese Medicine Decoction by Integrating UPLC-QTOF-MS and UFLC-QQQ-MS and Its Application

An ultrasensitive fluorescent aptasensor based on truncated aptamer and AGET ATRP for the detection of bisphenol A

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