High preoperative neutrophil–lymphocyte ratio predicts biochemical recurrence in patients with localized prostate cancer after radical prostatectomy

Lee, Hakmin; Jeong, Seong Jin; Hong, Sung Kyu; Byun, Seok‐Soo; Lee, Sang Eun; Oh, Jong Jin

doi:10.1007/s00345-015-1701-6

Cited by 32 publications

(42 citation statements)

References 27 publications

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“…This finding is consistent with other smaller studies demonstrating that elevated NLR portends poor prognosis in solid tumor malignancies. [1][2][3][4][5][6][7][8][9][10][11][12][13] Other studies in patients with hepato-pancreato-biliary (HPB) cancers agree with the findings presented in this paper. In a study of 452 patients who underwent a HPB procedure for malignant disease, NLR >5 was found to be associated with worse OS.…”

Section: Discussionsupporting

confidence: 91%

“…Elevated NLR is independently associated with worse outcomes in cancers of the breast, 1,2 thyroid, 3 colon, 4 stomach, 5 prostate, 6 lung, 7 adrenal, 8 pancreas 9,10 urogenital tract, 11 esophagus 12 and in glioblastoma, 13 as well as hematologic cancers, including multiple myeloma 14 and diffuse large B-cell lymphoma. 15 According to a recent systematic review and meta-analysis including 100 studies and greater than 40,000 patients, high NLR is associated with adverse overall survival (OS) in many solid tumors.…”

Section: Introductionmentioning

confidence: 99%

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Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Beal

Wei

Ethun

et al. 2016

HPB

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Beal

Wei

Ethun

et al. 2016

HPB

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“…N/L oranı ucuz ve kullanımı kolay bir parametre olması sebebiyle prostat kanserinde bu konularda yararlı olma potansiyeli taşımaktadır. Yüz kırk lokalize prostat kanseri hastasını incelediğimiz bu çalışmamızda N/L oranı ile PSA, patolojik evre, Gleason skoru, lenf nodu tutulumu, tümör hacmi, cerrahi sınır pozitifliği ve (14). Radikal prostatektomi uygulanmış 1688 hastanın incelendiği bir başka çalışmada da yüksek N/L oranı (>2,36) yüksek cerrahi evre (T3-T4), lenf nodu invazyonu ve biyokimyasal rekürrenssiz sağkalımla ilişkili bulunmuştur.…”

Section: Discussionunclassified

Is Preoperative Neutrophil Lymphocyte Ratio a Reliable Prognostic Parameter for Localized Prostate Cancer?

Ipekci¹,

Tunçkıran²,

Yüksel³

et al. 2018

jus

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Objective:In spite of all efforts, prostate cancer is still the 2 nd highest cause of cancer-related deaths in men. For this reason new developments are needed in diagnosis, treatment and follow-up of prostate cancer. Neutrophil/lymphocyte (N/L) ratio is a cheap and effective parameter used for research into many solid tumors; but there are not enough studies on the reliability of this parameter in prostate cancer. In this study we researched the efficacy of N/L ratio in localized prostate cancer. Materials and Methods: Between March 9, 2012 and April 23, 2017, the data of 140 patients who underwent radical prostatectomy with localized prostate cancer were screened retrospectively. The patients' ages, preoperative prostate specific antigen (PSA) and N/L ratio, pathologic stage, pathologic Gleason score, tumor volume, lymph node involvement, surgical margin positivity and presence or absence of 3 rd month biochemical recurrence were noted. The correlations between N/L ratio with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence were investigated. Results: The mean age of patients was 63.0±5.9 years, mean PSA value was 10.8±8.5 ng/mL and mean N/L ratio was 2.5±1.9. There was no correlation found between N/L ratio and PSA, pathologic stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity and biochemical recurrence (p>0.05). Conclusion: In our study investigating 140 patients with localized prostate cancer, we did not identify any correlation between N/L ratio and PSA, surgical stage and Gleason score, surgical margin positivity, and 3 rd month biochemical recurrence. When the literature is investigated, it appears that N/L ratio is effective for metastatic prostate cancer. To provide a more accurate judgment of the role of N/L ratio in localized prostate cancer, there is a need for new studies with broader patient series. Keywords: Inflammation, neutrophil-to-lymphocyte ratio, prostate cancer Amaç: Tüm uğraşılara rağmen prostat kanseri halen erkeklerde kanser nedenli ölümlerin 2. nedenidir. Bu sebeplerle prostat kanserinin tanı, tedavi ve izleminde yeni gelişmelere ihtiyaç duyulmaktadır. Nötrofil/ lenfosit (N/L) oranı birçok solid tümörde hakkında araştırma yapılan ucuz ve etkin bir parametredir, fakat prostat kanserinde bu parametrenin güvenilirliği konusunda yeterli sayıda çalışma bulunmamaktadır. Biz bu çalışmamızda lokalize prostat kanserinde N/L oranının etkinliğini araştırdık. Gereç ve Yöntem: 9 Mart 2012 ile 23 Nisan 2017 tarihleri arasında lokalize prostat kanseri tanısıyla radikal prostatektomi uygulanan 140 hastanın verileri retrospektif olarak tarandı. Hastaların yaş, preoperatif prostat spesifik antijen (PSA) ve N/L oranı, patolojik evre, patolojik Gleason skoru, tümör volümü, lenf nodu tutulumu, cerrahi sınır pozitifliği ve 3. ay biyokimyasal nüks bulunup bulunmadığı not edildi. N/L oranının yaş, PSA, patolojik parametreler, cerrahi sınır pozitifliği ve biyokimyasal nüks ile ilişkisi incelendi. Bulgular: Hastaların ortalama yaşı 63,0±...

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“…Minardi et al reported that patients with high NLRs had a greater incidence of BCR [18]. Moreover, Lee and colleagues retrospectively analyzed 1367 patients and found that a high NLR was significantly related to unfavorable clinicopathological outcomes and shorter BCR-free survival [17]. Others reported that high NLR was associated with higher BCR risk.…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer

et al. 2016

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BackgroundThe pretreatment neutrophil-to-lymphocyte ratio has prognostic value after radical prostatectomy for treating localized prostate cancer. However, the use of postoperative neutrophil-to-lymphocyte ratio has not been evaluated in this population. We investigated the prognostic significance of early postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for prostate cancer.MethodsWe retrospectively reviewed clinical data from 2,302 patients with localized prostate cancer who underwent radical prostatectomy at our institution between years 2000 and 2010. Only patients with pre- and postoperative complete blood counts with differential results were included. Patients who received neoadjuvant or postoperative adjuvant treatment and those without adequate medical records were excluded. Kaplan-Meier analyses were performed to analyze biochemical recurrence-free survival and overall survival rates. Univariate and multivariate Cox regression models were used for each endpoint.ResultsKaplan-Meier curves showed that high postoperative neutrophil-to-lymphocyte ratio (>3.5) was significantly associated with decreased biochemical recurrence-free survival (p = 0.009) and overall survival (p = 0.010). In the univariate and multivariate Cox regression analyses, high postoperative neutrophil-to-lymphocyte ratio was a significant predictor of biochemical recurrence (hazard ratio 1.270, p = 0.008) and overall survival (hazard ratio 1.437, p = 0.033).ConclusionsOur results demonstrate that postoperative neutrophil-to-lymphocyte ratio is an independent factor for biochemical recurrence and overall survival in patients who underwent radical prostatectomy for prostate cancer. These findings suggest that neutrophil-to-lymphocyte ratio can be a potentially valuable tool for stratifying high-risk patients and facilitating choices of postoperative therapy in patients with prostate cancer.

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High preoperative neutrophil–lymphocyte ratio predicts biochemical recurrence in patients with localized prostate cancer after radical prostatectomy

Abstract: High NLR was significantly related to unfavorable clinicopathological outcomes and worse BCR-free survival. Further studies are needed to clarify the correlation between NLR and PCa.

Cited by 32 publications

References 27 publications

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Is Preoperative Neutrophil Lymphocyte Ratio a Reliable Prognostic Parameter for Localized Prostate Cancer?

The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer

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