High Pressure Liquid Chromatography

Michaelis, A.; Cornish, D.W.; Vivilecchia, Richard

doi:10.1002/jps.2600620902

Cited by 25 publications

(4 citation statements)

References 143 publications

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“…Modern science has revealed scorpion venoms are complex mixtures of components including salts, lipids, small molecules, and proteins (Eauclaire- Martin and Couraud 1995). In the 1970s and 1980s, advancements in chromatographic techniques, such as the development of high-performance liquid chromatography Michaelis et al 1973), enabled the separation and purification of venom peptides to homogeneity, thus allowing for the first time the study of individual peptides to determine their function. In the 1970s and 1980s, advancements in chromatographic techniques, such as the development of high-performance liquid chromatography Michaelis et al 1973), enabled the separation and purification of venom peptides to homogeneity, thus allowing for the first time the study of individual peptides to determine their function.…”

Section: Cross-referencesmentioning

confidence: 99%

Scorpion Venoms

2015

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In recent years, the field of toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast-developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, diabetes, chronic pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever-growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to toxinology. Composed of 11 volumes, Toxinology provides comprehensive and authoritative coverage of the main areas in toxinology, from fundamental concepts to new developments and applications in the field. Each volume comprises a focused and carefully chosen collection of contributions from leading names in the subject.

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Section: Cross-referencesmentioning

confidence: 99%

Scorpion Venoms

2015

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“…:0020 Page:1292 Issue:06 Yr.:72 AA, 25 000308. (111) Kala, H., Itiemer, J.; Pharmazie; Vol. :0028 Page:0443 Issue:07 Yr.:73 CA, 80 019629K.…”

Section: G | G Sunclassified

“…Volume 16 on reports on progress in polymer physics in Japan was published in 1973 (46). Polymer materials science was reviewed by Schultz (111) and in two volumes edited by Jenkins (47,48). Guillet (29) edited a publication on polymers and ecological problems based primarily on a symposium sponsored by three ACS Divisions and the National Academy of Sciences.…”

Section: Table IX (Continued)mentioning

confidence: 99%

Pharmaceuticals and related drugs

Huettemann¹,

Cotter²,

Shaw³

et al. 1975

Anal. Chem.

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He is the co-author of several publications. His fields of interest include analytical methodology, drug metabolism, bioavailability-bioequivalency studies, physical and chemical properties of drugs, spectra interpretation, and natural product research. He is a member of the American Chemical Society and the American Pharmaceutical Association. * Author to whom reprint requests should be directed.CharFes J. Shaw is a Scientist in the Analytical Research Group, Division of Chemical Research, at Ortho Pharmaceutical Corp., Raritan, NJ. He graduated from La-Salle College in 1959 and received his M.S. from St. Joseph's College in 1969. He has had experience in analytical methods development for the pharmaceutical and chemical industry and is presently responsible for the mass spectrometry laboratory. His area of interest includes metabolism, analytical separation methods, and structural elucidation using spectral techniques. He is a member of the American Chemical Society and the Scientific Research Society of America. He is also the co-author of several publications.

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“…However, the application of HPLC to drug analysis has lagged behind the increase in its general use (1,2). However, the application of HPLC to drug analysis has lagged behind the increase in its general use (1,2).…”

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confidence: 99%