High prevalence of bone disorders after gastrectomy

Zittel, Tilman T.; Zeeb, Beate; Maier, Gerhard; Kaiser, G. W.; Zwirner, M.; Liebich, H.M.; Starlinger, M; Becker, H. D.

doi:10.1016/s0002-9610(97)00123-2

Cited by 125 publications

(97 citation statements)

References 27 publications

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“…Since gastric acid is thought to be necessary for the absorption of dietary calcium, osteoporosis in gastrointestinal diseases has been attributed to calcium deficiency [9][10][11][12] . Helicobacter pylori (HP) infection also causes chronic gastritis and may cause i n f l a m m a t i o n b y i n c r e a s i n g l o c a l a n d s y s t e m i c inflammatory markers such as TNF-alpha and IL-6 [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

Akkaya

Polat

et al. 2011

J Phys Ther Sci

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Abstract.[Purpose] The results of studies investigating the role of Helicobacter pylori (HP) in osteoporosis are contradictory. In this study we investigated HP seropositivity in postmenopausal osteoporotic and non-osteoporotic females to elucidate the role of HP in postmenopausal osteoporosis. [Subjects and Methods] Serum was collected from fifty-eight osteoporotic patients and forty-seven nonosteoporotic subjects, whose status was diagnosed with dual-energy X-ray absorptiometry (DEXA). None of the subjects had received any prior treatment for osteoporosis. Subjects' sera were assessed for HP antibodies (Immunoglobulin A and G) by enzyme-linked immunoabsorbent assay (ELISA). Patients were interviewed about risk factors of osteoporosis. Prior fractures of patients and familial fracture history were also noted.[Results] Fifty-eight patients with osteoporosis and forty-seven nonosteoporotic patients, as determined by lumbar total or collum femoris in DEXA, were evaluated in this study. The familial fracture history was significantly higher in the osteoporotic patients than in the nonosteoporotic group. There was no significant difference in HP seropositivity between the osteoporotic and nonosteoporotic groups.[Conclusion] There was no difference in HP seropositivity between the groups, therefore HP infection seems not to be an important risk factor for postmenopausal osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

Akkaya

Polat

et al. 2011

J Phys Ther Sci

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“…We studied changes in circulating VD metabolites in patients who had undergone a gastrectomy for gastric cancer. Although a change in VD metabolism was observed, the increase in PTH that has been reported by other authors was not seen [6]. This suggests that post-gastrectomy bone disorders may progress slowly without an increase in PTH, unlike the fi ndings in hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 60%

“…[8] Nevertheless, it is reasonable to expect that bone metabolism could be improved by rectifying the changes in VD metabolism. Zittel et al [6 ] reported that the serum Ca level was decreased, while the serum levels of Ca-regulating PTH and 1,25(OH) 2 VD were increased, in patients who had had a total gastrectomy compared with control subjects, and these changes were more prominent after a total gastrectomy than after subtotal gastrectomy. This is a different outcome to the result of our study, and may indicate the necessity for taking ethnic differences into consideration.…”

Section: Discussionmentioning

confidence: 99%

“…As drugs that inhibit bone resorption by osteoclasts have also been developed recently [4,5], a variety of treatment options is now available to manage bone disorders arising after gastrectomy for gastric cancer. It has been reported that the serum level of 25(OH) vitamin D3 is decreased and the serum level of 1,25(OH) 2 vitamin D3 is increased in gastrectomy patients [6]. However, to the best of our knowledge, there have been no reports about changes in vitamin D3 (VD) metabolites.…”

Section: Introductionmentioning

confidence: 99%

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Changes in vitamin D after gastrectomy

et al. 2007

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“…A high prevalence of bone disorders has been reported in gastrectomized patients (45), and osteopenia following total gastrectomy in animals was initially reported in 1938 (5). Despite several attempts over the past six decades to prevent this phenomenon, none has been successful.…”

Section: Fos and Bonementioning

confidence: 99%

The Effect on Bone of Stimulated Intestinal Mineral Absorption Following Fructooligosaccharide Consumption in Rats

Morohashi

2002

Bioscience Microflora

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Several studies have been carried out to establish the role of calcium and magnesium in bone. These minerals may play an important role in bone structure or strength. Fructooligosaccharides (FOS) are known to be stimulators of intestinal mineral absorption. In intact rats, bone volume and the mineral content (Ca, and Mg ) of the bone surface are greater in FOS-fed rats. Moreover, a significant relationship exists between the absorption of these minerals and their content in bone. Osteopenia is known to follow total gastrectomy in animals, leading to the severe concordant loss of both cortical and cancellous bone. These findings are similar to senile osteoporosis in humans. Dietary FOS completely prevents the gastrectomy-induced osteopenia in rats. If similar effects are found in humans, an increase in mineral deposition in bone during growth may contribute to the prevention of bone disease with age. Thus FOS might be a promising prebiotic for bone.

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High prevalence of bone disorders after gastrectomy

Cited by 125 publications

References 27 publications

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

Helicobacter Pylori Seropositivity in Patients with Postmenopausal Osteoporosis

Changes in vitamin D after gastrectomy

The Effect on Bone of Stimulated Intestinal Mineral Absorption Following Fructooligosaccharide Consumption in Rats

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