High prevalence of high-risk human papillomavirus infection among women with Trichomonas vaginalis infection on monolayer cytology

Noël, Jean Christophe; Fayt, Isabelle; Munoz, M.; Simon, Philippe; Engohan-Aloghe, Corinne

doi:10.1007/s00404-009-1291-x

Cited by 33 publications

(20 citation statements)

References 14 publications

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“…Concomitant STIs and vaginal infections may lead to prolonged HPV infection, which may in turn increase the risk of CIN [19, 20]. Bacterial vaginosis (BV) and Trichomonas vaginalis (TV), have been associated with an increased risk of squamous intraepithelial lesions and/or CIN based on biopsy results [21, 22]. …”

Section: Introductionmentioning

confidence: 99%

Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population

Menon

Broeck

Rossi³

et al. 2017

Infect Agents Cancer

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Background Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp.The aims of this cross-sectional analysis in Kenya are to explore the epidemiology of abnormal cytology and the pairing of pHR/HPV genotypes in HIV-negative and HIV-infected FSW.MethodsA cross-sectional study design of 616 FSW from Western Kenya aged between 18 and 61 years during 2009–2015 using a peer recruitment sampling strategy.ResultsOf the 599 FSW who underwent cytological examination, 87 had abnormal cytology (14.5%; 95% CI: 12.0–17.6%). A combined prevalence of HPV16 and 18 (29.6%; 95% CI: 22.2–37.8%) was observed in abnormal cytology. HPV 53 and 51 were the most observed pairing in FSW with abnormal cytology. Significant adjusted associations were found between abnormal cytology and TV (aOR: 30; 95% CI: 14.1–62.9), multiple HR HPV (aOR: 3.7; 95% CI: 1.9–7.3), HPV 51 (aOR 3.7; 95% CI 1.6–8.6) and HPV 52 (aOR 6.1; 95% CI: 2.8–13.3).ConclusionHPV 51 and 52 were independently associated with abnormal cervical cytology in both HIV negative/positive FSW. The strong association between TV and cervical dysplasia and the high percentage of FSW harbouring more than one STI underscore the need for enhanced STI management within the framework of cervical cancer prevention.

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Section: Introductionmentioning

confidence: 99%

Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population

Menon

Broeck

Rossi³

et al. 2017

Infect Agents Cancer

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“…In another study, T. vaginalis was found in 80 of the patients (0.2%) [43]. Of these 80 patients, 57 were available for HR-HPV testing (age: 8 patients <30 years, 42 patients 30–50 years, and 7 patients 50 years).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Association between Vaginal Infections and High-Risk Human Papillomavirus Types in Female Sex Workers in Spain

Rodríguez-Cerdeira

Sánchez-Blanco

Alba

2012

ISRN Obstetrics and Gynecology

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Background. Infection with and persistence of high-risk human papillomavirus (HR-HPV) are the strongest risk factors for cervical cancer. In addition, other genital microorganisms may also be involved in the progression of HPV-associated lesions. Objetive. To evaluate the association of the vaginal microbiota (Candida spp., Trichomonas vaginalis, and bacterial vaginosis) with HR-HPV infection in Spanish female sex workers (FSWs). Methods. This cross-sectional study involved 208 (FSWs; age, 18–49 years) who visited a sexually transmitted infection (STI) information and prevention center (SERGAS) between January 2010 and December 2011. Face-to-face interviews were carried out. Cervical and vaginal samples were examined for human papillomavirus (HPV), Trichomonas vaginalis, Candida spp., and microorganisms related to bacterial vaginosis (BV). Results. HR-HPV was found to be significantly associated with BV in FSWs with positive results for HPV16-related types (31, 33, 35, and 52). T. vaginalis was isolated in FSWs with the following HR-HPVs: 18, 45, 66, and 68. Candida spp. were isolated only in FSWs with HPV 18-positive infection. Conclusion. We demonstrate a significant prevalence of HR-HPVs in FSWs with disturbances in the vaginal microbiota.

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“…The spectrum of clinical presentation range from asymptomatic or slightly symptomatic, particularly in men, to severe vaginitis with abundant vaginal secretions in women [13]. Infections with this protozoan can lead to serious health problems such as infertility, preterm delivery, low birth weight [14,15], susceptibility to cervical cancer [15] or increased prevalence of high risk human papillomavirus (HPV) infection [16]. Moreover, there is a strong association between T. vaginalis infection and acquisition of HIV [17].…”

Section: The Most Frequent Causative Agent Of Stdsmentioning

confidence: 99%

The Advantages of Using Multiplex PCR for the Simultaneous Detection of Six Sexually Transmitted Diseases

Vică¹,

Matei²,

Siserman³

2016

Polymerase Chain Reaction for Biomedical Applications

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Sexually transmitted diseases (STDs) are among the most common infections. Their clinical identification is difficult because STDs are often asymptomatic. Untreated infections with these pathogens can in time lead to serious consequences. It is documented that isolation of some of these bacteria from cultures is very difficult. Because there is a large number of STD pathogens which can generate coinfections, their simultaneous detection in a unique sample is very important. Multiplex polymerase chain reaction (PCR) is an advanced method of molecular biology which allows for simultaneous detection of multiple pathogens in the same sample. The advantages of the multiplex PCR method were assessed by various researchers by comparing the diagnosis results obtained with different other conventional methods. The sensitivity and specificity of these methods were analyzed on different specimens in comparison to traditional methods, such as culture media or direct microscopic examination. These studies demonstrated beyond any doubt that the multiplex PCR system is highly effective in the detection of each of multiple STD pathogens depicted from a single specimen and argued for multiplex PCR superiority in terms of sensitivity and rapidity.

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High prevalence of high-risk human papillomavirus infection among women with Trichomonas vaginalis infection on monolayer cytology

Cited by 33 publications

References 14 publications

Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population

Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population

Evaluation of Association between Vaginal Infections and High-Risk Human Papillomavirus Types in Female Sex Workers in Spain

The Advantages of Using Multiplex PCR for the Simultaneous Detection of Six Sexually Transmitted Diseases

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