High prevalence of somatic symptoms and depression in women with disabling chronic headache

Tietjen, Gretchen E.; Brandes, Jan Lewis; Digre, Kathleen B.; Baggaley, Susan; Martin, Vincent T.; Recober, Ana; Geweke, Lynne O.; Hafeez, Faizan; Aurora, Sheena K.; Herial, Nabeel A.; Utley, Christine; Khuder, Sadik A.

doi:10.1212/01.wnl.0000251195.55563.02

Cited by 68 publications

(54 citation statements)

References 50 publications

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“…There are data to suggest that in the general population and among non-dialysis patients with chronic conditions and after major trauma, women also face higher prevalence of depression and poorer HRQOL [14,15,16,17]. There is also evidence that, among non-dialysis patients, depression plays a role in explaining the poorer HRQOL in women than in men [18,19].…”

Section: Discussionmentioning

confidence: 99%

Depression as a Potential Explanation for Gender Differences in Health-Related Quality of Life among Patients on Maintenance Hemodialysis

et al. 2010

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Background/Aims: The reasons for lower health-related quality of life (HRQOL) scores in women compared to men on maintenance hemodialysis (MHD) are unknown. We investigated whether depression accounts for gender differences in HRQOL. Methods: Cross-sectional study of 868 (40.9% women) Brazilian MHD patients (PROHEMO Study). We used the Kidney Disease Quality of Life Short Form to assess HRQOL and the Center for Epidemiological Studies Depression (CES-D) scale (scores from 0–60) to assess depression with scores ≧18 indicating high depression probability. Results: Higher depression scores were associated with lower HRQOL in both sexes. Women had higher depression scores; 51.8% of women versus 38.2% of men (p < 0.001) had CES-D scores ≧18. Women scored lower on all 9 assessed HRQOL scales. The female-to-male differences in HRQOL were slightly reduced with inclusion of Kt/V and comorbidities in regression models. Substantial additional reductions in female-to-male differences in all HRQOL scales were observed after including depression scores in the models, by 50.9% for symptoms/problems related to renal failure, by 71.6% for mental health and by 87.1% for energy/vitality. Conclusions: Lower HRQOL among women was largely explained by depression symptoms. Results support greater emphasis on treating depression to improve HRQOL in MHD patients, particularly women.

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Section: Discussionmentioning

confidence: 99%

Depression as a Potential Explanation for Gender Differences in Health-Related Quality of Life among Patients on Maintenance Hemodialysis

et al. 2010

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“…It is conceivable that patients with frequent migraine attacks and loss of quality of life may develop depression. In women with chronic migraine referred to headache specialty clinics a strong association to major depression was found (OR = 31.8, 95 % CI = 12.9-78.5) [97]. Patients with major depressive disorder and comorbid migraine were shown to have pronounced anxiety and physical symptoms.…”

Section: Migraine and Depressionmentioning

confidence: 97%

Migraine-associated risks and comorbidity

2008

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This review reports important co-morbid conditions of migraine and resulting consequences for the choice of acute and preventive treatments of migraine. Comorbidity in this context means the occurrence of two diseases in an individual beyond chance. The basis of comorbidity can be genetic and/or based on common environmental factors. In some cases, the temporal relationship is unclear and one disease can cause another disease. In order to prove a real comorbidity, large-scale and well-performed epidemiological studies are required.

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“…Although their mechanism of action includes effects on hyperalgesia and trigeminal nociceptor activation, no studies have clarified the effects of these drugs on the severity of central sensitization symptoms and FM comorbidity, and evidence is lacking in regard to their use in chronic musculo skeletal pain. Depression,which is a factor favouring FM comorbidity in chronic headache patients [18,26,61], may be induced or aggravated by flunarizine treatment [62]. …”

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confidence: 99%

Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches

Tommaso

2012

Expert Review of Neurotherapeutics

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Fibromyalgia (FM) syndrome is predominantly related to generation and persistence of central sensitization, which is an aggravating factor for chronic headaches. This review aims to examine the last 11 years of studies on FM and primary headache comorbidity, focusing on prevalence, clinical features and treatments. Chronic forms of migraine and tension-type headache show a high frequency of FM comorbidity. The symptoms characterizing headache patients presenting with FM comorbidity are high headache frequency, poor sleep quality, pericranial tenderness, anxiety and reduction of physical performances. The effects of headache-preventive drugs on factors favoring FM comorbidity were poorly evaluated. Nonpharmacological approaches such as transcranial magnetic stimulation may be an option for treatment of chronic migraine associated with FM. Keywords: fibromyalgia • migraine • tension-type headache • therapeutic optionsPrevalence, clinical features and potential therapies for fibromyalgia in primary headaches Expert Rev. Neurother. 12(3), 287-296 (2012) THeMed ArTICLe y Migraine & Headache Learning objectivesUpon completion of this activity, participants will be able to:• Describe the prevalence and underlying pathophysiology of FM comorbid with headache • Describe the clinical characteristics of FM comorbid with headache • Describe available treatments for FM comorbid with headache Medscape: Continuing Medical Education OnlineThis activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Expert Reviews Ltd. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at http://www.medscape.org/journal/expertneurothera; (4) view/print certificate. For reprint orders, please contact reprints@expert-reviews.com CME Expert Rev. Neurother. 12(3), (2012) 288 Review Possible causes of comorbidity between fibromyalgia & primary headachesFibromyalgia (FM) is a chronic pain syndrome of unknown etiology characterized by diffuse pain over more than 3 months and tenderness in at least 11 tender point sites out of 18 [1]. The diagnostic criteria have recently been revised in view of the full consideration of the complexity of symptoms associated with generalized pain, including nonrestorative sleep, fatigue and cognitive dysfunction, with less importance attributed to the number of painful tender points [2].The causes of F...

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High prevalence of somatic symptoms and depression in women with disabling chronic headache

Cited by 68 publications

References 50 publications

Depression as a Potential Explanation for Gender Differences in Health-Related Quality of Life among Patients on Maintenance Hemodialysis

Depression as a Potential Explanation for Gender Differences in Health-Related Quality of Life among Patients on Maintenance Hemodialysis

Migraine-associated risks and comorbidity

Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches

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