High rate of TTV infection in multitransfused patients with pediatric malignancy and hematological disorders

Maeda, Miho; Hamada, Hisamitsu; Tsuda, Akio; Kaneko, Kiyoshi; Fukunaga, Yoshitaka

doi:10.1002/1096-8652(200009)65:1<41::aid-ajh7>3.3.co;2-0

Cited by 2 publications

(1 citation statement)

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“…68 The non-enveloped single stranded DNA virus is particularly prevalent in patients with frequent parenteral exposure. 69 Like HGV virus, TTV is efficiently transmitted from mother to child, 70 with long term persistent infection. TTV is commonly associated with hepatitis B (13%), hepatitis C (16%), hepatitis A (5%), and hepatitis E (20%), but there was no correlation between coinfection, TTV titre, and liver damage, suggesting that TTV may not have a pathological role.…”

Section: Transfusion Transmissable Virus (Ttv)mentioning

confidence: 99%

Hepatitis C-Z: recent advances

Kelly

Skidmore²

2002

Archives of Disease in Childhood

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Section: Transfusion Transmissable Virus (Ttv)mentioning

confidence: 99%

Hepatitis C-Z: recent advances

Kelly

Skidmore²

2002

Archives of Disease in Childhood

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Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia

Shaheli

Yaghobi

Rezaeian

et al. 2015

Jundishapur J Microbiol

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Background:The pathogenic association of Transfusion Transmitted Virus or Torque teno Virus (TT Virus) single and mixed infections with leukemia was under evaluation in these years but confront with controversies. This hypothesis is based on the higher prevalence of TT Virus infection in patients with leukemia compared with controls.Objectives:The aim of this study was to determine the frequency of TT Virus, Cytomegalovirus (CMV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) infections in patients with leukemia and healthy controls.Patients and Methods:In this cross sectional study, 95 patients with leukemia and 100 healthy controls who were admitted to the Namazi Hospital affiliated to the Shiraz University of Medical Sciences, Shiraz, Iran, were enrolled between years 2012 and 2013. Blood samples treated with EDTA were collected from each patient with leukemia and controls. The existence of TT Virus infection was analyzed using the semi-nested PCR method. The immunological prevalence of HBV and HCV infections were evaluated using HBs-Ag and HCV-Ab ELISA based protocols, respectively. Active CMV infection was also evaluated using an immunofluorescence method. Also risk factors of leukemia and viral infections were statistically analyzed in patients with leukemia.Results:The TT Virus infection was significantly found in 40 of 95 (42.1%) and 12 of 100 (12%) patients with leukemia and controls, respectively. The HBs-Ag and HCV-Ab were detected in 27 of 95 (28.4%) and 18 of 69 (26.1%) patients with leukemia but were not found in the controls. Active CMV infection was also found in 11 of 69 (16%) patients and none of the controls. Significant co-infection of TT Virus was found with HBV (15 of 40; 37.5%), HCV (14 of 40; 35%) and CMV (7 of 40; 17.5%) in patients with leukemia.Conclusions:Confirmation of the significantly higher frequency of TT Virus, HBV, HCV and CMV single infection and their co-infection in patients with leukemia compared with healthy controls, emphasizes the determinative role of TT Virus pathogenesis in clinical outcomes observed in patients with leukemia, which requires extensive evaluation by further studies.

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High rate of TTV infection in multitransfused patients with pediatric malignancy and hematological disorders

Cited by 2 publications

References 0 publications

Hepatitis C-Z: recent advances

Hepatitis C-Z: recent advances

Study of the Associations Between TT Virus Single and Mixed Infections With Leukemia

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