High rates of fatigue and sleep disturbances in dystonia

Shukla, Aparna Wagle; Brown, Riki; Heese, Katherine; Jones, Jacob D.; Rodríguez, Ramón; Malaty, I M; Okun, Michael S.; Kluger, Benzi M.

doi:10.3109/00207454.2015.1085035

Cited by 30 publications

(17 citation statements)

References 25 publications

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“…ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ, 12,2017 патическими и генетическими формами дистонии отмечено снижение отдельных функций -концентрации внимания, зрительно-пространственной ориентации, но эти нарушения обычно бывают легкими и потенциально связанными с болью, нарушением сна или депрессией.…”

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“…B научных публикациях последних лет [11,12] описан ряд дополнительных симптомов, рассматриваемых как «немоторные симптомы» дистонии: в первую очередь боль, сенсорные ощущения и нарушения сна. Клинические исследования, показывающие высокую частоту депрессии у больных с МД, а также растущее признание того, что наличие дисфункции в корково-лимбико-подкорковых связях влияет на формирование депрессии и других психических расстройств, делает необходимым дальнейшее исследование эмоционального состояния при первичной дистонии [13].…”

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Emotional and personality characteristics of patients with dystonia

Чернуха

Tarasevich

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Higher levels of anxiety and depression in patients with dystonia compared to the control groups were identified. The level of anxiety and depression was not correlated with disease severity. Personality profile study confirmed the high level of anxiety in patients with dystonia and additionally showed increased emotional instability and poor emotional control. Intellectual personality characteristics of patients with dystonia had no differences compared to the control groups. An analysis of socio-psychological characteristics of personality in patients with dystonia and GFS showed restricted interpersonal and social communications since the motor defect noticeable to others leads to severe social exclusion and the desire for self-isolation.

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Emotional and personality characteristics of patients with dystonia

Чернуха

Tarasevich

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…The PDSS has been extensively used in PD and there is some experience in a dystonia cohort including patients with generalized, segmental, and focal dystonia ( 19 ).…”

Section: Nocturnal Sleep (Ns) Disturbancesmentioning

confidence: 99%

“…It also has been widely used in PD ( 10 ) and in other hypokinetic disorders such as MSA ( 117 , 118 ). In addition, there is experience with this scale in hyperkinetic disorders such as Huntington’s disease ( 14 , 119 , 120 ), dystonia ( 19 , 121 , 122 ), and essential tremor ( 123 – 125 ).…”

Section: Diurnal Sleep Disorders: Eds and Sleep Attacksmentioning

confidence: 99%

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A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders

et al. 2018

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Patients with movement disorders have a high prevalence of sleep disturbances that can be classified as (1) nocturnal sleep symptoms, such as insomnia, nocturia, restless legs syndrome (RLS), periodic limb movements (PLM), obstructive sleep apnea (OSA), and REM sleep behavior disorder; and (2) diurnal problems that include excessive daytime sleepiness (EDS) and sleep attacks. The objective of this review is to provide a practical overview of the most relevant scales that assess these disturbances to guide the choice of the most useful instrument/s depending on the line of research or clinical focus. For each scale, the reader will find a brief description of practicalities and psychometric properties, use in movement disorder cohorts and analyzed strengths and limitations. To assess insomnia, the Pittsburgh Sleep Quality Index, a generic scale, and three disease-specific scales: the Parkinson Disease Sleep Scale (PDSS), the PDSS-2, and Scales for outcomes in Parkinson’s disease (PD)-Sleep-Nocturnal Sleep subscale are discussed. To evaluate nocturia, there are no specific tools, but some extensively validated generic urinary symptom scales (the Overall Bladder Questionnaire and the Overactive Bladder Symptom Score) and some PD-specific scales that include a nocturia item are available. To measure RLS severity, there are currently four domain-specific generic scales: The International Restless Legs Scale, the Johns Hopkins Restless Legs Severity Scale, the Restless Legs Syndrome-6 measure, a Pediatric RLS Severity Scale, and the Augmentation Severity Rating Scale (a scale to evaluate augmentation under treatment) and several instruments that assess impact on quality of sleep and health-related quality of life. To evaluate the presence of PLM, no clinical scales have been developed to date. As far as OSA, commonly used instruments such as the Sleep Apnea Scale of the Sleep Disorders Questionnaire, the STOP-Bang questionnaire, and the Berlin Questionnaire are reviewed. Three scales have been extensively used to assess EDS: the generic Epworth Sleepiness Scale, the Stanford Sleepiness Scale, and the PD-specific Scales for outcomes in PD-Sleep-Daytime sleepiness subscale. To date, only the Inappropriate Sleep Composite Score specifically evaluates propensity to sleep attacks.

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Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients

Smit

Kamphuis

Bartels

et al. 2016

Movement Disord Clin Pract

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Background: Nonmotor symptoms (NMS) are highly prevalent in cervical dystonia (CD). In general, fatigue and sleep are important NMS that determine a decreased health-related quality of life (HR-QoL), but their influence in CD is unknown. The authors systematically investigated fatigue, excessive daytime sleepiness (EDS), and sleep quality in patients with CD and controls and assessed the influence of psychiatric comorbidity, pain, and dystonia motor severity. They also examined the predictors of HR-QoL. Methods: The study included 44 patients with CD and 43 matched controls. Fatigue, EDS, and sleep quality were assessed with quantitative questionnaires and corrected for depression and anxiety using analysis of covariance. The Toronto Western Spasmodic Torticollis Rating Scale and the Clinical Global Impression Scalejerks/tremor subscale were used to score motor severity and to assess whether motor characteristics could explain an additional part of the variation in fatigue and sleep-related measures. HR-QoL was determined with the RAND-36 item Health Survey, and predictors of HR-QoL were assessed using multiple regression. Results: Fatigue scores were increased independently from psychiatric comorbidity (4.0 vs. 2.7; P < 0.01), whereas EDS (7.3 vs. 7.4; P = 0.95) and sleep quality (6.5 vs. 6.1; P = 0.73) were highly associated with depression and anxiety. In patients with CD, motor severity did not explain the variations in fatigue (change in the correlation coefficient [DR 2 ] = 0.06; P = 0.15), EDS (DR 2 = 0.00; P = 0.96), or sleep quality (DR 2 = 0.04; P = 0.38) scores. Fatigue, EDS, psychiatric comorbidity, and pain predicted a decreased QoL. Conclusion: Independent from psychiatric comorbidity and motor severity, fatigue appeared to be a primary NMS. Sleep-related measures were highly associated with psychiatric comorbidity, but not with motor severity. Only NMS predicted HR-QoL, which emphasizes the importance of attention to NMS in patients with CD.

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High rates of fatigue and sleep disturbances in dystonia

Abstract: Fatigue and sleep disturbances revealed high prevalence rates in this large, first of its dystonia study. They negatively impacted the quality of life even when controlled for comorbid depression.

Cited by 30 publications

References 25 publications

Emotional and personality characteristics of patients with dystonia

Emotional and personality characteristics of patients with dystonia

A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders

Fatigue, Sleep Disturbances, and Their Influence on Quality of Life in Cervical Dystonia Patients

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