High Rates of Multidrug-Resistant Tuberculosis in the Country of Georgia: A Population-Based Study.

Lomtadze, Nino; Salakaia, Archil; Aspindzelashvili, Rusudan; Janjgava, Marina; Blumberg, Henry M.

doi:10.1097/00042871-200701010-00741

Cited by 78 publications

(110 citation statements)

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“…There have been mixed findings regarding gender as a risk factor for having drug-resistant TB (14)(15)(16)21). In the present study, while no association was found between drug resistance and age, a statistically significant association was found between male sex and drug resistance.…”

Section: Discussioncontrasting

confidence: 61%

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

et al. 2010

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Drug-resistant tuberculosis (TB) presents a major challenge to global TB control. To gain a better understanding of drug-resistant TB epidemiology in Malatya, Turkey, we conducted the present study using 397 Mycobacterium tuberculosis clinical isolates collected from Malatya, Turkey, in recent years (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007). Resistance to any anti-TB drug was found in 29% (114 of 397) of the study isolates, while the multidrug resistance (MDR) rate was ϳ4.5% (18 of 397). Resistances to isoniazid (15.5%) and streptomycin (13.4%) were about twice as high as resistance to rifampin (RMP) (6.3%) and ethambutol (EMB) (6.0%). Importantly, 28% (7 of 25) of the RMP-resistant isolates were non-MDR isolates, as when a significant proportion of RMPresistant isolates in a population are non-MDR, the predictive value of molecular detection of RMP resistance for MDR can be significantly reduced. Both identical and varied drug resistance patterns were seen in the same genotyping-defined clusters, suggesting that both primary and acquired resistance have contributed to the drug-resistant TB epidemic in Malatya, Turkey. In addition, drug-resistant cases were found to be more likely to be males (odds ratio [95% confidence interval], 1.82 [1.13, 2.94]), suggesting a potential role of gender in the epidemiology of drug-resistant TB in the study population. This study demonstrates that the integration of drug susceptibility testing with genotyping and epidemiological data analysis represents a useful approach to studying the epidemiology of drug-resistant TB.

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Section: Discussioncontrasting

confidence: 61%

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

et al. 2010

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“…45% in retreatment cases [9][10][11][12]. Because Ukraine and the Russian Federation are countries with high numbers of inhabitants (45 and 143 million, respectively) in contrast to Georgia (4.3 million inhabitants), it is to be expected that more MDR-TB patients are observed originating from Ukraine and the Russian Federation than from Georgia.…”

Section: Discussionmentioning

confidence: 99%

A surge of MDR and XDR tuberculosis in France among patients born in the Former Soviet Union

et al. 2013

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“…determined previously administered TB treatment as an important risk factor for the development of drug resistance TB and reported that this situation increased development of drug resistance by five times on average. 11 A study by Faustine et. al.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of Multidrug Resistant Tuberculosis in central Nepal: A pilot study

Marahatta

Kaewkungwal

Ramasoota

et al. 2012

Kathmandu Univ. Med. J.

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High Rates of Multidrug-Resistant Tuberculosis in the Country of Georgia: A Population-Based Study.

Cited by 78 publications

References 0 publications

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

Integration of Mycobacterium tuberculosis Drug Susceptibility Testing and Genotyping with Epidemiological Data Analysis To Gain Insight into the Epidemiology of Drug-Resistant Tuberculosis in Malatya, Turkey

A surge of MDR and XDR tuberculosis in France among patients born in the Former Soviet Union

Risk factors of Multidrug Resistant Tuberculosis in central Nepal: A pilot study

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