High Resistance of Mongolian Gerbils to Irradiation

Chang, M. C.; Hunt, Dorothy M.; Turbyfill, C. L.

doi:10.1038/203536a0

Cited by 29 publications

(3 citation statements)

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“…The radiological phenomena associated with Zeman UJ90 melanomas are congruent with earlier observations on a general radioresistance of Mongolian gerbils [ 173 , 174 , 175 , 176 ]. All that makes the Mongolian gerbil a really unique laboratory animal in the context of melanoma radiotherapy studies.…”

Section: Gerbils As Animal Models For Chemically-induced Melanomassupporting

confidence: 88%

Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials

Śniegocka

Podgórska

Płonka

et al. 2018

IJMS

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The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection. Experimental models of melanoma in hamsters and in gerbils are described as well as their use in biochemical and radiobiological studies, including a spontaneously metastasizing ocular model. Some results from in vitro studies on the inhibition of melanogenesis are presented as well as radio-chelation therapy in experimental and clinical settings. In contrast to cutaneous melanoma, uveal melanoma is very successfully treated with radiation, both using photon and proton beams. We point out that the presence or lack of melanin pigmentation should be considered, when choosing therapeutic options, and that both the experimental and clinical data suggest that melanin could be a target for radiosensitizing melanoma cells to increase efficacy of radiotherapy against melanoma.

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Section: Gerbils As Animal Models For Chemically-induced Melanomassupporting

confidence: 88%

Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials

Śniegocka

Podgórska

Płonka

et al. 2018

IJMS

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show abstract

“…Both experiments suggest that the pika is relatively sensitive to ionizing radiation in comparison to other wild mammals (Chang et al , 1964;Golley et al, 1965;Gambino and Lindberg, 1964;Provost et al , 1965) and similar in sensitivity to laboratory mice (Roderick, 1963).…”

Section: Discussionmentioning

confidence: 95%

RADIATION LD$sub 50$/$sub 30$ OF PIKAS (OCHOTONA PRINCEPS) IN THE NATURAL ENVIRONMENT AND IN CAPTIVITY.

Markham¹,

Whicker²

1970

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“…Ha sido utilizado en experimentos con radiaciones (Chang et al, 1964). Al presentar una mayor resistencia a las radiaciones que la mayoría de los roedores se han realizado investigaciones sobre la influencia de las radiaciones en la muerte celular y la aparición de aberraciones cromosómicas (Suzuki et al, 1992).…”

Section: Utilización En Experimentaciónunclassified

El jerbo como modelo de anemia por oxidación

Cerdeira¹

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High Resistance of Mongolian Gerbils to Irradiation

Cited by 29 publications

References 1 publication

Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials

Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials

RADIATION LD$sub 50$/$sub 30$ OF PIKAS (OCHOTONA PRINCEPS) IN THE NATURAL ENVIRONMENT AND IN CAPTIVITY.

El jerbo como modelo de anemia por oxidación

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