High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip

Shi, Yu; Xiong, Shiyun; Chin, Lip Ket; Yang, Yi; Zhang, Jing Bo; Ser, Wee; Wu, Jiu Hui; Chen, Tian Ning; Yang, Zhen; Yi, Hao; Liedberg, Bo; Yap, P. H.; Zhang, Yi; Liu, Ai Qun

doi:10.1039/c7lc00484b

Cited by 55 publications

(39 citation statements)

References 52 publications

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“…Therefore, plotting the Poynting vector surrounding the chiral particle is an intuitive way to elucidate the optical forces. According to Minkowski's approach 36 , the optical force increases n times in a dielectric medium (n is the refractive index of the medium) due to the momentum transfer; thus, the medium effect for a liquid with a higher refractive index is more prominent [37][38][39][40] .…”

Section: Principle Of the Optical Lateral Force On Mie Chiral Particlesmentioning

confidence: 99%

Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

et al. 2020

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Lateral optical forces induced by linearly polarized laser beams have been predicted to deflect dipolar particles with opposite chiralities toward opposite transversal directions. These "chirality-dependent" forces can offer new possibilities for passive all-optical enantioselective sorting of chiral particles, which is essential to the nanoscience and drug industries. However, previous chiral sorting experiments focused on large particles with diameters in the geometrical-optics regime. Here, we demonstrate, for the first time, the robust sorting of Mie (size~wavelength) chiral particles with different handedness at an air-water interface using optical lateral forces induced by a single linearly polarized laser beam. The nontrivial physical interactions underlying these chirality-dependent forces distinctly differ from those predicted for dipolar or geometrical-optics particles. The lateral forces emerge from a complex interplay between the light polarization, lateral momentum enhancement, and out-of-plane light refraction at the particle-water interface. The sign of the lateral force could be reversed by changing the particle size, incident angle, and polarization of the obliquely incident light.

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Section: Principle Of the Optical Lateral Force On Mie Chiral Particlesmentioning

confidence: 99%

Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

et al. 2020

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“…To achieve higher resolution, a new way to use quasi-Bessel beam was reported, which had a low numerical aperture (NA) and small focus ( Fig. 6(d)) 62 . Experimental results show that it separated individual nanoparticles with diameter ranging from 60 nm to 100 nm and resolution of 10 nm for the first time.…”

Section: Biochemical Samples Manipulation and Sensing In Flowing Liquidsmentioning

confidence: 99%

“…61 , American Chemical Society; (d) ref. 62 , The Royal Society of Chemistry; (e) ref. 63 ; (f) ref.…”

Section: Biochemical Samples Manipulation and Sensing In Flowing Liquidsmentioning

confidence: 99%

Optofluidics: the interaction between light and flowing liquids in integrated devices

Zhu¹,

Zhu²,

Zuo³

et al. 2019

Opto-Electronic Advances

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Optofluidics is a rising technology that combines microfluidics and optics. Its goal is to manipulate light and flowing liquids on the micro/nanoscale and exploiting their interaction in optofluidic chips. The fluid flow in the on-chip devices is reconfigurable, non-uniform and usually transports substances being analyzed, offering a new idea in the accurate manipulation of lights and biochemical samples. In this paper, we summarized the light modulation in heterogeneous media by unique fluid dynamic properties such as molecular diffusion, heat conduction, centrifugation effect, light-matter interaction and others. By understanding the novel phenomena due to the interaction of light and flowing liquids, quantities of tunable and reconfigurable optofluidic devices such as waveguides, lenses, and lasers are introduced. Those novel applications bring us firm conviction that optofluidics would provide better solutions to high-efficient and high-quality lab-on-chip systems in terms of biochemical analysis and environment monitoring.

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“…By regulating the thermal lens, the trapping of the living cell can be modulated at a range of 280 µm. Recently, Aiqun Liu’s group has demonstrated the manipulation of particles with sizes of several 10s nanometers using optical potential wells created by an in-plane focused beam and fluidic constraints in optofluidic chips [ 47 , 48 ]. The combination of the quasi-Bessel optical profile and the loosely overdamped potential wells enable the precise manipulation of nanoparticles in the optofluidic channel.…”

Section: Applications Of In-plane Liquid Lensesmentioning

confidence: 99%

Optofluidic Tunable Lenses for In-Plane Light Manipulation

Chen

et al. 2018

Micromachines

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Optofluidics incorporates optics and microfluidics together to construct novel devices for microsystems, providing flexible reconfigurability and high compatibility. Among many novel devices, a prominent one is the in-plane optofluidic lens. It manipulates the light in the plane of the substrate, upon which the liquid sample is held. Benefiting from the compatibility, the in-plane optofluidic lenses can be incorporated into a single chip without complicated manual alignment and promises high integration density. In term of the tunability, the in-plane liquid lenses can be either tuned by adjusting the fluidic interface using numerous microfluidic techniques, or by modulating the refractive index of the liquid using temperature, electric field and concentration. In this paper, the in-plane liquid lenses will be reviewed in the aspects of operation mechanisms and recent development. In addition, their applications in lab-on-a-chip systems are also discussed.

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High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip

Cited by 55 publications

References 52 publications

Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation

Optofluidics: the interaction between light and flowing liquids in integrated devices

Optofluidic Tunable Lenses for In-Plane Light Manipulation

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