High-Resolution CT Chest Findings in Suspected COVID-19 Pneumonia Patients With Negative Real-Time Polymerase Chain Reaction Assay

Yusuf, Salim; Ahmad, Habib; Zeb, Romasa; Zeb, Uswa; Zeb, Ahmed A

doi:10.7759/cureus.14023

Cited by 7 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study from Egypt has also shown similar results, by reporting a non-significant difference across positive and negative RT-PCR results [ 18 ]. Another study from Pakistan on chest HRCT scan findings in patients with RT-PCR-negative results has reported that 79.2% of patients had ground-glass opacities [ 19 ]. In comparison, our study reported ground-glass appearance in 98.7% of RT-PCR-positive COVID-19 patients and in 100% of RT-PCR-negative COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of High-Resolution Computed Tomography Scan in COVID-19: Do We Need to Think Outside the Box?

Khan¹,

Janjua²,

Jamal³

et al. 2021

Cureus

View full text Add to dashboard Cite

Background and objectiveThe ambiguous nature and high infectivity of the coronavirus disease 2019 (COVID-19) have caused soaring morbidity and mortality worldwide. Real-time polymerase chain reaction (RT-PCR) is preferred for detecting COVID-19. However, its poor sensitivity and the emerging use of high-resolution CT (HRCT) scan for disease severity make the use of RT-PCR quite obsolete. In light of this, our study aimed to explore the beneficial role of HRCT and compare the HRCT findings across various patient demographics and parameters. MethodsThis cross-sectional study included 100 patients with clinical suspicion of COVID-19. All patients underwent a chest HRCT scan preceded by RT-PCR testing. We used the CT severity score (CTSS) of the chest to calculate disease severity. Demographical data and results of radiological findings were tabulated and compared across RT-PCR positivity, age, and gender. Independent samples t-test and chi-square test were used to analyze the data. ResultsGlass ground opacity was the most prevalent finding in 99% of the patients, followed by lymph node involvement, consolidation, and crazy-paving pattern. Pleural effusion was observed in only 10% of the patients while pericardial effusion and hiatal hernia were present in 5%. In RT-PCR-positive patients, the posterior basal segment of the lower lobe of the right and left lungs were found to be dominantly involved; however, the upper and middle lobes of the right lung were more commonly involved than the left lung. The mean CTSS was significantly higher in patients aged above 50 years (p<0.001). The mean CTSS of RT-PCRnegative patients was higher than that of p=0.537). ConclusionRT-PCR has a limited role in the diagnosis of COVID-19. The HRCT scan can detect typical COVID-19 findings even in patients with negative RT-PCR results. Moreover, the use of HRCT scan in determining the disease severity and extent of lung damage can lead to a better assessment of critically ill patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of High-Resolution Computed Tomography Scan in COVID-19: Do We Need to Think Outside the Box?

Khan¹,

Janjua²,

Jamal³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

“…16 Therefore, the diagnosis of COVID-19 pneumonia was considered based on a report from a qualified radiologist together with the satisfaction of the treating physician with HRCT findings, particularly ground-glass opacities. [17][18][19] 3. Typical clinical presentation plus history of close contact with patients with COVID-19 confirmed by RT-PCR.…”

Section: Patient Diagnostic Strategymentioning

confidence: 99%

Correlation of SARS-CoV-2 infection severity with ABO blood groups and RhD antigen: a case-control study

et al. 2022

View full text Add to dashboard Cite

Objective The role of ABO types and RhD antigen in coronavirus disease 2019 (COVID-19) severity has been investigated in several recent studies. Thus, the objective of this study was to identify the relationship of ABO and RhD types with symptomatic COVID-19 disease and determine the groups associated with an increased risk of hospitalization. Methods This observational case-control study was performed in 530 Iraqi-Kurdish patients with COVID-19. Among them, 184 were severe cases that required hospitalization, while 346 were mild to moderate cases that were treated at home. ABO and RhD antigen groups were compared between cases and 1698 control records from 1 year before the pandemic. The diagnosis of COVID-19 was based on real-time polymerase chain reaction tests and high-resolution chest computed tomography scans with the typical clinical presentation. Results There were no significant differences in ABO and RhD antigen distributions between the COVID-19 cases and non-COVID controls. No ABO group was associated with the risk of hospitalization as a marker of the severity of infection. Conclusions There was no significant association between symptomatic COVID-19 disease and any ABO group or RhD antigen type. No impact of ABO groups on hospitalization was documented.

show abstract

“…Various other researches also reported the similar findings. Furthermore, it was observed that it was observed that posterior region lower lobe involvement was a feature of COVID-19 patients while crazy paving pattern and peripheral distribution was also seen in corona positive patients [14][15][16][17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Chest Computed Tomography Differential Diagnosis of Ground Glass Opacities in the COVID-19 Patients

Ullah¹,

Memon²,

Rasul³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Aim: To compare chest computed tomography (CT) diagnosis of ground glass opacities in the COVID-19 patients. Study design: Retrospective study. Place and duration of study: Department of Radiology, Ghulam Muhammad Mahar Medical College Sukkur from 1st July 2020 to 31 August 2021. Methodology: Fifty patients on differential CT diagnosis of ground glass opacities seen in COVID 19 patients were enrolled. Thoracic CT images by applying auto exposure-control settings and ranges of scan were done. The noise-index was kept as 12.3. Using helical 16 slice Alexion CT-Toshiba. Keeping a comparison with viral infection CT images a list of 7 signs which were positive for Covid CT scan were recorded. Peripheral lesions meant any lesions which effects peripheral area up to 3 to 4 cm lung periphery with/without having central dispersal. A hazy-opacity was termed as ground glass. Results: Mean age of the patients was 49.1±10.2 years with 27 (54%) males and 23(46%) females. Mix ground glass opacitites and consolidation were also the features of the CT imaging in coronavirus posisitve cases. Man-Whitney test results showed that combined-CT scoring had a SE value as 0.044 with a confidence interval between 0.756-0.927. Comparing the differential CT values within COVID and non COVID patients based on RT PCR results it was observed that posterior region lower lobe involvement was a feature of COVID-19 patients while crazy paving pattern and peripheral distribution was also seen in corona patients. Conclusion: Present study highlights that chest CT helps in differentitaing corona virus from other causes of pneumonias and grond glass opacities. Key words: Chest CT; Differential diagnosis; COVID-19; Ground glass opacities (GGO)

show abstract

High-Resolution CT Chest Findings in Suspected COVID-19 Pneumonia Patients With Negative Real-Time Polymerase Chain Reaction Assay

Cited by 7 publications

References 15 publications

Diagnostic Value of High-Resolution Computed Tomography Scan in COVID-19: Do We Need to Think Outside the Box?

Diagnostic Value of High-Resolution Computed Tomography Scan in COVID-19: Do We Need to Think Outside the Box?

Correlation of SARS-CoV-2 infection severity with ABO blood groups and RhD antigen: a case-control study

Comparison of Chest Computed Tomography Differential Diagnosis of Ground Glass Opacities in the COVID-19 Patients

Contact Info

Product

Resources

About