2020
DOI: 10.1038/s42003-020-1034-x
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High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish

Abstract: In non-mammalian vertebrates, some neurons can regenerate after spinal cord injury. One of these, the giant Mauthner (M-) neuron shows a uniquely direct link to a robust survivalcritical escape behavior but appears to regenerate poorly. Here we use two-photon microscopy in parallel with behavioral assays in zebrafish to show that the M-axon can regenerate very rapidly and that the recovery of functionality lags by just days. However, we also find that the site of the injury is critical: While regeneration is p… Show more

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Cited by 13 publications
(17 citation statements)
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“…Panels C and D adapted from Hecker et al . 2020 a , as stated under Creative Commons license https://creativecommons.org/licenses/by/4.0/.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Panels C and D adapted from Hecker et al . 2020 a , as stated under Creative Commons license https://creativecommons.org/licenses/by/4.0/.…”
Section: Introductionmentioning
confidence: 99%
“…(Adapted from Hecker et al . 2020 a , as stated under Creative Commons license https://creativecommons.org/licenses/by/4.0/). C , in C elegans , 24 h after axotomy of a DD motoneuron (red arrow), two axon branches regenerated (green arrow).…”
Section: Introductionmentioning
confidence: 99%
“…The M-axon regrows past spinal cord lesions and forms functional synapses in Xenopus laevis tadpoles (Lee, 1982), while the ability of M-axons to regrow in urodele larvae decreases with age (Holtzer, 1952;Piatt, 1955). Larval zebrafish M-axons have the capacity to regrow caudal to a wound and form synapses after laser axotomy (Hu et al, 2018), and such regrowth results in the return of fast C-starts after spinal cord lesions (Bhatt et al, 2004;Hecker et al, 2020a). In contrast, the regrowth in larval lamprey, adult urodeles, and teleost fish is more limited.…”
Section: Mauthner-axon Sprouts Are Capable Of Regrowing Across Spinomedullary Level-crush Woundsmentioning
confidence: 99%
“…A pair of identifiable cells, the Mauthner cells (M-cells), are known to initiate fast C-type startle responses (fast C-starts; Zottoli, 1977;Eaton et al, 1981;Hecker et al, 2020b) and S-starts (Liu and Hale, 2017). Axonal regrowth of lesioned Mauthner axons (M-axons) results in functional synaptic connections with motoneurons in Xenopus tadpoles (Lee, 1982) and recovery of fast C-starts in larval zebrafish (Bhatt et al, 2004;Hecker et al, 2020a). However, the role of M-cells in post-injury startle responses of adult fish is less clear.…”
Section: Introductionmentioning
confidence: 99%
“…The neuromast is a susceptible epithelium, and it will move according to the direction of flowing water that passes along the lateral line (Herzog et al, 2015). The movement stimulates the sensory nerves to send signals to the central nerve and responds in the form of coordinated body movement and orientation (Hecker et al, 2020).…”
Section: Introductionmentioning
confidence: 99%