High-resolution MRI of the mouse cerebral vasculature to study hemodynamic-induced vascular remodeling

Rajabzadeh-Oghaz, Hamidreza; Chandra, Anusha Ramesh; Gutierrez, Liza; Schweser, Ferdinand; Ionita, Ciprian N.; Siddiqui, Adnan H.; Tutino, Vincent M.

doi:10.1117/12.2511772

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…This less invasive imaging modality makes MRA an optimal instrument for serial imaging in long-term studies. Indeed, safe serial imaging in long-term studies using MRA was performed in dogs [113], mouse [143,156,174], rats [96,136,137,181], and rabbit elastase IA models [18,169]. Several studies in human suggest that MRA could be considered equivalent to DSA to detect IAs [7].…”

Section: Conventional Catheter Angiographymentioning

confidence: 99%

“…The resolution of CTA seems to be increased when combined with a flat detector [102]. MRA resolution can be improved using a higher magnetic field (7 T or even 9.4 T), which has been shown to allow for accurate imaging of the rat circle of Willis [156,168,174]. More recently, HF-OCT showed a great potential to assess appropriate treatment of IAs, thanks to a very high-spatial resolution close to 10 μm [182].…”

Section: Comparison Of the Ia In Vivo Imaging Techniquesmentioning

confidence: 99%

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Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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Section: Conventional Catheter Angiographymentioning

confidence: 99%

Section: Comparison Of the Ia In Vivo Imaging Techniquesmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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“…In fact, only a few studies use them other than as IA detection tools, for instance to detect macrophage infiltration or to perform CFD analysis on 3DRA images ( 77 , 99 ). To the best of our knowledge, only 2 studies managed to follow aneurysmal remodeling in mice over 3 months using really high-field MRI (9,4T) ( 100 , 101 ). Regarding IA's hemodynamics, Doppler ultrasound imaging can be used to measure blood flow velocity in rabbit models of internal carotid aneurysm ( 99 , 102 , 103 ).…”

Section: Inflammation Imagingmentioning

confidence: 99%

Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Maupu

Lebas

Boulaftali

2022

Front. Cardiovasc. Med.

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Intracranial aneurysms (IA) are often asymptomatic and have a prevalence of 3 to 5% in the adult population. The risk of IA rupture is low, however when it occurs half of the patients dies from subarachnoid hemorrhage (SAH). To avoid this fatal evolution, the main treatment is an invasive surgical procedure, which is considered to be at high risk of rupture. This risk score of IA rupture is evaluated mainly according to its size and location. Therefore, angiography and anatomic imaging of the intracranial aneurysm are crucial for its diagnosis. Moreover, it has become obvious in recent years that several other factors are implied in this complication, such as the blood flow complexity or inflammation. These recent findings lead to the development of new IA imaging tools such as vessel wall imaging, 4D-MRI, or molecular MRI to visualize inflammation at the site of IA in human and animal models. In this review, we will summarize IA imaging techniques used for the patients and those currently in development.

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