High risk of bacterobilia in advanced experimental chronic fasciolosis

Valero, M. Adela; Navarro, Miriam; Garcia-Bodelon, M. A.; Marcilla, Antonio; Morales, María Pérez; Hernández, José L.; Mengual, P; Mas‐Coma, Santiago

doi:10.1016/j.actatropica.2006.09.002

Cited by 75 publications

(40 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human cases have been increasing in the five continents, including estimates of human infection of up to 17 million people, or even higher depending from the hitherto unknown situations in Asia and Africa (Mas-Coma et al 2009a). This disease has recently proven to have a great morbidity impact throughout the biliary or chronic period of the disease (Valero et al 2003(Valero et al , 2006aGirones et al 2007), and not only due to the pathogenicity of the acute phase as hitherto believed (Chen and Mott, 1990). Clinical studies have shown this disease to be pronouncedly complex, giving rise to progressive general deterioration of the patients, with sequelae sometimes *Corresponding author: Madela.Valero@uv.es Syed Ali Ahasan et al 268 leaving them handicapped and frail, even including fatal cases (Mas-Coma et al 2014a).…”

Section: Introductionmentioning

confidence: 99%

CIAS detection of Fasciola hepatica/F. gigantica intermediate forms in bovines from Bangladesh

Ahasan¹,

Valero

Chowdhury

et al. 2016

Acta Parasitologica

View full text Add to dashboard Cite

Fascioliasis is an important food-borne parasitic zoonosis caused by two trematode species, Fasciola hepatica and Fasciola gigantica. The characterisation and differentiation of Fasciola populations is crucial to control the disease, given the different transmission, epidemiology and pathology characteristics of the two species. Lineal biometric features of adult liver flukes infecting livestock have been studied to characterise and discriminate fasciolids from Bangladesh. An accurate analysis was conducted to phenotypically discriminate between fasciolids from naturally infected bovines (cattle, buffaloes) throughout the country. Morphometric analyses were made with a computer image analysis system (CIAS) applied on the basis of standardised measurements and the logistic model of the body growth and development of fasciolids in the different host groups. Since it is the first ever comprehensive study of this kind undertaken in Bangladesh, the results are compared to pure fasciolid populations of F. hepatica from the European Mediterranean area and F. gigantica from Burkina Faso, geographical areas where both species do not co-exist. Principal component analysis showed that the biometric characteristics of fasciolids from Bangladesh are situated between F. hepatica and F. gigantica standard populations, indicating the presence of phenotypes of intermediate forms in Bangladesh. These results are analysed by considering the present emergence of animal fascioliasis, the local lymnaeid fauna, the impact of climate change, and the risk of human infection in the country.

show abstract

Section: Introductionmentioning

confidence: 99%

CIAS detection of Fasciola hepatica/F. gigantica intermediate forms in bovines from Bangladesh

Ahasan¹,

Valero

Chowdhury

et al. 2016

Acta Parasitologica

View full text Add to dashboard Cite

show abstract

“…In both laboratory animals and ruminants, fascioliasis, like other helminth infections, is a potent inducer of Th2 responses that impair the ability to mount any effective Th1 responses against bacteria and other pathogens [48,49]. A high risk of bacterobilia in advanced experimental chronic fascioliasis has been described in a rat model and supports this fact [50]. Extrapolation of the results obtained in the rat model to human infection gives a new dimension to chronic fascioliasis.…”

Section: Discussionmentioning

confidence: 50%

Immune Suppression in Advanced Chronic Fascioliasis: An Experimental Study in a Rat Model

et al. 2007

View full text Add to dashboard Cite

Today, fascioliasis is considered to be an important human disease caused by 2 liver fluke species, Fasciola hepatica and Fasciola gigantica (Fasciolidae), infecting the liver of a wide range of mammals [1] that show a marked variability in their immune response against infection [2]. There are several geographic regions that have been reported to be areas of hypoendemicity, mesoendemicity, and hyperendemicity for fascioliasis in

show abstract

“…This disease in humans shows an increasing importance, which does rely not only on the recent widespread emergence it has shown but also on the results obtained in studies on pathogenicity (Mas-Coma et al, 1999a;Valero et al, 2003Valero et al, , 2006Valero et al, , 2008 and immunity (Brady et al, 1999;Gironés et al, 2007), according to which this disease appears to be pronouncedly more complicated and with a greater impact in long-term infection than what was believed until the 1990s. In human endemic areas, fascioliasis chronicity and superimposed repetitive infections pose additional pathological complications .…”

Section: Introductionmentioning

confidence: 91%