High risk of mumps infection in children who received one dose of mumps-containing vaccine: waning immunity to mumps in children aged 2-5 years from kindergartens in Jiangsu Province, China

Sun, Xiang; Tang, Fenyang; Hu, Ying; Deng, Xin; Wang, Zhiguo; Zhou, Minghao; Liu, Yuanbao

doi:10.1080/21645515.2019.1708162

Cited by 9 publications

(8 citation statements)

References 30 publications

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“… 19 , 21 Our research is consistent with these observations and likely provides an explanation of frequent mumps outbreaks in children and adolescents. 22 The mumps vaccine component of MMR elicits a lower immune response than do the measles and rubella components. 23 Studies in Scandinavia document persistence of antibodies in children derived from the Jeryl Lynn mumps strain, with 73% seroconversion in Sweden after a single dose.…”

Section: Discussionmentioning

confidence: 99%

“…32 Sun and colleagues found that children who received a single dose of MMR vaccine in kindergarten, particularly 2-year-olds in northern Jiangsu province, China, were at high risk of mumps infection. 22 Mumps outbreaks occurred in campuses in Fujian Province in 2018, and the cases were mainly among 12–15 year olds. 10 , 11 Finally, MuV has only one serotype but 12 distinct genotypes (A – L).…”

Section: Discussionmentioning

confidence: 99%

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Mumps serological surveillance following 10 years of a one-dose mumps-containing-vaccine policy in Fujian Province, China

Liu¹,

Zhang²,

You

et al. 2022

Human Vaccines & Immunotherapeutics

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Background Since 2008, Fujian province provided measles-rubella (MR) vaccine at 8 months followed by measles-mumps-rubella (MMR) vaccine at 18 months a one-dose mumps-containing-vaccine (MuCV) schedule. Several mumps outbreaks have occurred recently in Fujian. Serological surveillance can assess population immunity to mumps and identify risk factors for mumps. Methods We conducted a cross-sectional serosurvey of mumps IgG antibodies in the general population of Fujian Province in 2018 and compare results with a similar study conducted in 2009, when the routine schedule had no MuCV. We analyzed changes in mumps epidemiology after implementation of a one-dose MuCV vaccination strategy. Results Mumps seroprevalence was 78.6% (95% CI: 77.4–79.8), and the geometric mean concentration (GMC) of mumps antibodies was 245.8 IU/ml (95% CI:237.3–255.1). MuCV vaccination at 18 months resulted in increased seroprevalence and GMCs. Seroprevalence and GMCs varied by age, gender, and number of doses received. Except for children under 18 months, seroprevalence and GMCs were lowest among 10-15-year-olds. Each year after introduction of the one-dose MuCV vaccination policy, the highest incidence of mumps was among 4–6-year-olds and 9–15-year-olds, gradually shifting to older age groups. Conclusion A one-dose mumps-containing vaccine schedule does not provide sustained and stable mumps immunity in Fujian. To reduce the risk of mumps, we recommend supplementary vaccination of children without a history of receiving at least one MuCV dose or who are seronegative at 10–15 years of age.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mumps serological surveillance following 10 years of a one-dose mumps-containing-vaccine policy in Fujian Province, China

Liu¹,

Zhang²,

You

et al. 2022

Human Vaccines & Immunotherapeutics

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“…According to a study conducted by Korczyńska and Rogalska, over 2000 cases of mumps were registered in 2014, and the majority of the sick children were not vaccinated or had only one dose of vaccine [15]. According to Sun et al, children vaccinated with only one dose of MMR vaccine were still at risk of viral infection in comparison to children immunised with the two doses of MMR vaccine [16]. Therefore, it is important to monitor childhood vaccination coverage and to educate parents on the necessity of receiving a second dose of MMR vaccine.…”

Section: Resultsmentioning

confidence: 99%

Implementation of the preventive vacc ination program against measles, mumps, and rubella (MMR) on the example of a selected clinic in the city of Krakow

Wojczyk¹,

Cholewa²

2020

ppiel

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Aim of the study: The study aimed to examine the measles-mumps-rubella (MMR) vaccination coverage with the full vaccination schedule (two doses) in children aged 9 and 10 years, and the vaccination rate with the first dose in children aged three years, in the selected Primary Health Care facility. Material and methods: This is an ecological study, conducted by analysis of medical records. We researched the vaccination coverage of children aged 3, 9, and 10 years in each year between 2010 and 2019 and studied the data of 1610 children. Data were collected from vaccination records and annual vaccination coverage reports. The statistical analysis was done by using the chi-square and Kendall's tau tests. Results: The percentage of nine-year-olds vaccinated with a second dose of MMR between 2010 and 2019 was 55% on average (n = 913) and 86% (n = 855) in the group of one-year-older children. The number of nine-and 10-year-olds not vaccinated with any single dose of MMR did not increase significantly and oscillated between 0-2%. The average percentage of three-year-olds vaccinated with the first dose of MMR over a 10-year period was 95% (n = 1057). In 2019, however, the number of vaccinated children fell below 90% (86%), and the number of unvaccinated children more than doubled compared to 2018. Conclusions: A second dose of MMR vaccine in the studied group is often administered later than recommended in the immunisation schedule. The percentage of vaccinated 10-year-olds usually does not exceed 90%. There has been an increase in the number of unvaccinated children, mostly three-year-olds.

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“…There is other evidence supporting the meaningful importance of mumps intervention in the fight against mumps. First, since the program was introduced, children’s MMR vaccination rates have gradually increased year after year, with coverage rates for two year olds exceeding 95% in several provinces and cities of China [ 27 , 36 , 37 ]. Second, a study in Shanghai showed a high seroprevalence of mumps antibodies has been achieved in urban regions; mumps antibody seroprevalence reached 90% (95% CI: 90.0% to 90.2%) when adjusted for age and gender after the introduction of the MMR vaccination [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

A Multi-Age-Group Interrupted Time-Series Study for Evaluating the Effectiveness of National Expanded Program on Immunization on Mumps

et al. 2022

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The national Expanded Program on Immunization (EPI) in China has covered vaccines for measles, mumps, and rubella, among children aged 18–24 months since September 2008. However, no previous studies have quantified the effectiveness of the EPI on mumps incidence. There are methodological challenges in assessing the effect of an intervention that targets a subpopulation but finally influences the whole population. In this study, monthly data on mumps incidence were collected in Guangzhou, China, during 2005–2019. We proposed a multi-age-group interrupted time-series design, setting the starting time of exerting effect separately for 14 different age groups. A mixed-effects quasi-Poisson regression was applied to analyze the effectiveness of the EPI on mumps incidence, after controlling for long-term and seasonal trends, and meteorological factors. The model also accounted for the first-order autocorrelation within each age group. Between-age-group correlations were expressed using the contact matrix of age groups. We found that 70,682 mumps cases were reported during 2005–2019, with an annual incidence rate of 37.91 cases per 100,000 population. The effect of EPI strengthened over time, resulting in a decrease in the incidence of mumps by 16.6% (EPI-associated excess risk% = −16.6%, 95% CI: −27.0% to −4.7%) in September 2009 to 40.1% (EPI-associated excess risk% = −40.1%, 95% CI: −46.1% to −33.3%) in September 2019. A reverse U-shape pattern was found in age-specific effect estimates, with the largest reduction of 129 cases per 100,000 population (95% CI: 14 to 1173) in those aged 4–5 years. The EPI is effective in reducing the mumps incidence in Guangzhou. The proposed modeling strategy can be applied for simultaneous assessment of the effectiveness of public health interventions across different age groups, with adequate adjustment for within- and between-group correlations.

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High risk of mumps infection in children who received one dose of mumps-containing vaccine: waning immunity to mumps in children aged 2-5 years from kindergartens in Jiangsu Province, China

Cited by 9 publications

References 30 publications

Mumps serological surveillance following 10 years of a one-dose mumps-containing-vaccine policy in Fujian Province, China

Mumps serological surveillance following 10 years of a one-dose mumps-containing-vaccine policy in Fujian Province, China

Implementation of the preventive vacc ination program against measles, mumps, and rubella (MMR) on the example of a selected clinic in the city of Krakow

A Multi-Age-Group Interrupted Time-Series Study for Evaluating the Effectiveness of National Expanded Program on Immunization on Mumps

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